2.1.1.233: [phosphatase 2A protein]-leucine-carboxy methyltransferase

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For detailed information about [phosphatase 2A protein]-leucine-carboxy methyltransferase, go to the full flat file.

Reaction

Synonyms

C-terminal leucine protein carboxyl methyltransferase-1, LCMT-1, LCMT1, leucine carboxy methyltransferase-1, leucine carboxyl methyl transferase 1, leucine carboxyl methyltransferase, leucine carboxyl methyltransferase 1, leucine carboxyl methyltransferase 1 homolog, leucine carboxyl methyltransferase-1, leucine carboxylmethyltransferase-1, leucine carboxymethyltransferase 1/phosphatase methylesterase 1, phosphatase 2A protein methyltransferase, PME-1, PP2A LCMT, PP2A methyltransferase, PP2A-methyltransferase, PP2A-specific methyltransferase, PPM1, Ppm1p, PPMT, protein phosphatase 2A leucine carboxyl methyltransferase, protein phosphatase methyltransferase 1

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.233 [phosphatase 2A protein]-leucine-carboxy methyltransferase

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Results	in table
1	Activating Compound
3696	AA Sequence
7	Cloned(Commentary)
11	Cofactor
3	Crystallization (Commentary)
110	Disease/ Diagnostics
2	Expression
41	General Information
1	IC50 Value
2	Inhibitors
1	KM Value [mM]
11	Localization
5	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
28	Organism
1	pH Optimum
1	pI Value
13	Protein Variants
7	Purification (Commentary)
1	Reaction
28	Reference
48	Source Tissue
2	Specific Activity [micromol/min/mg]
37	Substrates and Products (Substrate)
5	Subunits
65	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.1.1.233 - [phosphatase 2A protein]-leucine-carboxy methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:[phosphatase 2A protein]-leucine O-methyltransferase

Methylates the C-terminal leucine of phosphatase 2A. A key regulator of protein phosphatase 2A. The methyl ester is hydrolysed by EC 3.1.1.89 (protein phosphatase methylesterase-1). Occurs mainly in the cytoplasm, Golgi region and late endosomes.