2.1.1.241: 2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase

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For detailed information about 2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase, go to the full flat file.

Reaction

Synonyms

BENZOXAZINLESS7, BX7, O-methyltransferase BX7, OMT BX7, TRIBOA-glucoside O-methyltransferase, TRIBOA-OMT

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.241 2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase

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Results	in table
1	AA Sequence
2	Cloned(Commentary)
2	Cofactor
1	Expression
4	General Information
1	Inhibitors
1	KM Value [mM]
1	Metals/Ions
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
2	Organism
5	Pathway
2	Purification (Commentary)
1	Reaction
2	Reference
2	Source Tissue
5	Substrates and Products (Substrate)
2	Subunits
7	Synonyms
1	Systematic Name

General Information

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General Information on EC 2.1.1.241 - 2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Zea mays

B1P123

gene Bx7 is part of a small gene family consisting of 15 members with higher sequence similarity to each other (62 to 99%), BX7 shows high similarity to BX14

757968

metabolism

2 entries

physiological function

Zea mays

-

Bx7 is required for biosynthesis of the benzoxazinoid pesticide 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one, i.e. DIMBOA, that is synthesized in seedlings and stored as glucoside in maize

723455

metabolism

Zea mays

-

Bx7 catalyzes the last step in benzoxazinoid biosynthesis of maize

723455

metabolism

Zea mays

B1P123

the enzyme is involved in benzoxazinoid formation in maize, overview. A 2-oxoglutarate-dependent dioxygenase (BX13, UniProt ID A0A1P8SET2) catalyzes the conversion of 2-(2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one)-beta-D-glucopyranose (DIMBOA-Glc) into a benzoxazinoid intermediate, 2-(2,4,7-trihydroxy-8-methoxy-1,4-benzoxazin-3-one)-beta-D-glucopyranose (TRIMBOA-Glc), by an uncommon reaction involving hydroxylation and a likely ortho-rearrangement of a methoxy group. TRIMBOA-Glc is then converted to 2-(2,4-dihydroxy-7,8-dimethoxy-1,4-benzoxazin-3-one)-beta-D-glucopyranose (DIM2BOA-Glc) by an O-methyltransferase BX7. Furthermore, an O-methyltransferase BX14 (UniProt ID A0A1P8SEU3) converts DIM2BOA-Glc to 2-(2-hydroxy-4,7,8-trimethoxy-1,4-benzoxazin-3-one)-beta-D-glucopyranose (HDM2BOA-Glc). HDM2BOA-Glc is known to be induced by biotic stresses such as pathogen infestation and insect feeding. The inducibility of HDM2BOA-Glc is associated with a stronger induction of genes Bx13 and Bx14. DIM2BOA-Glc and HDM2BOA-Glc specifically increase plant resistance against aphids

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