2.1.1.245: 5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase
This is an abbreviated version!
For detailed information about 5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.245
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2.1.1.245
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methanogen
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metr
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methanosarcina
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clostridium
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thermoaceticum
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ch3-h4folate
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n5-methyl
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pka
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cobalt
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ragsdale
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acetyl-enzyme
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h4folate
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barkeri
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thermophila
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ni
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cfesp
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exafs
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unprotonated
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pre-steady-state
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methane
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xanes
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cobiamide
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stopped-flow
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multienzyme
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shoemaker
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tetrahedral
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electrophilic
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companion
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cobalamin-dependent
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a-cluster
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organometallic
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h2o
- 2.1.1.245
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methanogen
- metr
-
methanosarcina
- clostridium
- thermoaceticum
-
ch3-h4folate
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n5-methyl
- pka
- cobalt
-
ragsdale
-
acetyl-enzyme
-
h4folate
- barkeri
- thermophila
- ni
-
cfesp
-
exafs
-
unprotonated
-
pre-steady-state
- methane
-
xanes
-
cobiamide
-
stopped-flow
-
multienzyme
-
shoemaker
-
tetrahedral
-
electrophilic
-
companion
-
cobalamin-dependent
-
a-cluster
-
organometallic
- h2o
Reaction
Synonyms
AcdS, acetyl-CoA decarbonylase/synthase complex, C/Fe-S enzyme, cdhD, CdhD1, cdhE, CH3-H4pteridine:cob(I)amide-protein methyltransferase, methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase, MeTr
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.245 - 5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase
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REACTION DIAGRAM
a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrosarcinapterin
a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrosarcinapterin
CH3-H4SPt + cob(I)amide-protein + H+
H4SPt + CH3-cob(III)amide-protein
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r
a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrosarcinapterin
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the reaction is performed by the intact gamma subunit and fragments of the delta subunit, components of the proteolyzed acetyl-CoA decarbonylase synthase, ACDS, complex, overview
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r
a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrosarcinapterin
a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrosarcinapterin
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structures of tetrahydrosarcinapterin and N5-methyl-tetrahydrosarcinapterin, overview. The reaction is performed by the intact gamma subunit and fragments of the delta subunit, components of the proteolyzed acetyl-CoA decarbonylase synthase, ACDS, complex, overview
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r
a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrosarcinapterin
a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrosarcinapterin
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a pH-dependent conformational change is required for methyl transfer in the forward and reverse directions, but this step is not rate-limiting
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r
a [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrosarcinapterin
a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrosarcinapterin
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a pH-dependent conformational change is required for methyl transfer in the forward and reverse directions, but this step is not rate-limiting, the pH-dependent protein conformational change in the ternary complex is linked to deprotonation of the active complexes
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r
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reduction of the cobalt atom of the corrinoid to Co1+ by Ti(III)citrate, the gamma subunit CdhE contains the single 4Fe-4S center in the C/Fe-S enzyme
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additional information
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reduction of the cobalt atom of the corrinoid to Co1+ by Ti(III)citrate, the gamma subunit CdhE contains the single 4Fe-4S center in the C/Fe-S enzyme
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additional information
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the methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase catalyzes transfer of the N5-methyl group from (6S)-methyltetrahydrofolate, i.e. CH3-H4folate, to the cobalt center of a corrinoid/iron-sulfur protein, CFeSP, forming methylcob(III)-amide and H4folate
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