2.1.1.246: [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase

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For detailed information about [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase, go to the full flat file.

Reaction

Synonyms

Co-methyl-5-hydroxybenzimidazolylcobamide:2-mercapto-ethanesulphonic acid methyltransferase, methanol-specific methyltransferase 2, methanol:cob(I)alamin methyltransferase, methanol:coenzyme M methyltransferase, methylcobalamin:coenzyme M methyltransferase, methylcobamide:coenzyme M methyltransferase, methylcobamide:CoM methyltransferase, methyltransferase 2, MT2, MT2-A, MT2-M, mtaA

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.246 [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase

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Results	in table
4	Activating Compound
47	AA Sequence
2	Application
1	CAS Registry Number
8	Cloned(Commentary)
4	Expression
13	General Information
3	Inhibitors
3	KM Value [mM]
9	Metals/Ions
3	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
30	Organism
3	Pathway
8	pH Optimum
6	Protein Variants
6	Purification (Commentary)
2	Reaction
14	Reference
7	Source Tissue
14	Specific Activity [micromol/min/mg]
17	Substrates and Products (Substrate)
4	Subunits
32	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 2.1.1.246 - [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

EDTA

Methanosarcina barkeri

-

75% inhibition at 1 mM, complete inhibition at 2 mM, reversible by Zn2+ addition, competitive versus Zn2+, kinetics, overview

717562

imidazole

Methanosarcina barkeri

-

the demethylation of cob(I)inamide reaction is inhibited by imidazole. Imidazole does not inhibit methyltransfer from methylcob(III)alamin to coenzyme M at 10 mM

717561

additional information

Methanosarcina barkeri

-

1 mm nitrilotriacetic acid has almost no effect on the MtaA activity

717562

-