2.1.1.246: [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase

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For detailed information about [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase, go to the full flat file.

Reaction

Synonyms

Co-methyl-5-hydroxybenzimidazolylcobamide:2-mercapto-ethanesulphonic acid methyltransferase, methanol-specific methyltransferase 2, methanol:cob(I)alamin methyltransferase, methanol:coenzyme M methyltransferase, methylcobalamin:coenzyme M methyltransferase, methylcobamide:coenzyme M methyltransferase, methylcobamide:CoM methyltransferase, methyltransferase 2, MT2, MT2-A, MT2-M, mtaA

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.246 [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase

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Results	in table
4	Activating Compound
47	AA Sequence
2	Application
1	CAS Registry Number
8	Cloned(Commentary)
4	Expression
13	General Information
3	Inhibitors
3	KM Value [mM]
9	Metals/Ions
3	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
30	Organism
3	Pathway
8	pH Optimum
6	Protein Variants
6	Purification (Commentary)
2	Reaction
14	Reference
7	Source Tissue
14	Specific Activity [micromol/min/mg]
17	Substrates and Products (Substrate)
4	Subunits
32	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.1.1.246 - [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) methanol-specific corrinoid protein]

5 entries

a [methyl-Co(III) methanol-specific corrinoid protein] + CoM

methyl-CoM + a [Co(I) methanol-specific corrinoid protein]

Methanosarcina barkeri

Q48949

-

756274

-

-

?

additional information

?

-

4 entries

a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) methanol-specific corrinoid protein]

Methanosarcina barkeri

-

-

717559, 717562

-

-

?

a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) methanol-specific corrinoid protein]

Methanosarcina barkeri

-

-

717561, 717563

-

-

r

a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) methanol-specific corrinoid protein]

Methanosarcina barkeri

O30640

-

717753

-

-

r

a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) methanol-specific corrinoid protein]

Methanosarcina barkeri Fusaro / DSM 804

-

-

717563

-

-

r

a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) methanol-specific corrinoid protein]

Methanosarcina barkeri Fusaro, DSM 804

-

-

717563

-

-

r

additional information

?

-

Methanosarcina acetivorans

-

methyltransferase 2, MT2, transfers the methyl group from the methylated corrinoid protein to coenzyme M, i.e. 2-mercaptoethanesulfonic acid. Methyl-coenzyme M is then disproportionated, with one molecule being oxidized to CO2 to provide the six electrons required for reduction of three additional methyl-coenzyme M molecules to methane

681980

-

-

?

additional information

?

-

Methanosarcina barkeri

-

transferase MtaA catalyzes the transfer of the methyl group from methylated transferase MtaBC to coenzyme M. Instead of methylated transferase MtaBC, MtaA can also use free methylcobalamin as the methyl donor. MtaA activates coenzyme M for nucleophilic attack of the methyl group of the methylcobamide

485665

-

-

?

additional information

?

-

Methanosarcina barkeri

O30640

conversions of monomethylamine and dimethylamine to CH3-SCoM are dependent upon MT2-A, and are not supported by MT2-M. In contrast, MT2-M acts specifically in metabolism of methanol, but does not substitute for MT2-A in conversion of monomethylamine or dimethylamine. Nevertheless, both isozymes are capable of supporting the conversion of trimethylamine

717753

-

-

?

additional information

?

-

Methanosarcina barkeri

-

conversions of monomethylamine and dimethylamine to CH3-SCoM are dependent upon MT2-A, and are not supported by MT2-M. In contrast, MT2-M acts specifically in metabolism of methanol, but does not substitute for MT2-A in conversion of monomethylamine or dimethylamine. Nevertheless, both isozymes are capable of supporting the conversion of trimethylamine

717753

-

-

?