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2.1.1.246: [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase

This is an abbreviated version!
For detailed information about [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.246

Reaction

a [methyl-Co(III) methanol-specific corrinoid protein]
+
CoM
=
methyl-CoM
+
a [Co(I) methanol-specific corrinoid protein]

Synonyms

Co-methyl-5-hydroxybenzimidazolylcobamide:2-mercapto-ethanesulphonic acid methyltransferase, methanol-specific methyltransferase 2, methanol:cob(I)alamin methyltransferase, methanol:coenzyme M methyltransferase, methylcobalamin:coenzyme M methyltransferase, methylcobamide:coenzyme M methyltransferase, methylcobamide:CoM methyltransferase, methyltransferase 2, MT2, MT2-A, MT2-M, mtaA

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.246 [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase

Specific Activity

Specific Activity on EC 2.1.1.246 - [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.01
-
purified recombinant mutant C239A MtaA, pH 7.0, 37°C
0.02
-
purified recombinant mutant H237A MtaA, pH 7.0, 37°C
0.154
MT2 activity in recombinant Escherichia coli cells transfected with gene cmtM, pH 7.2, 37°C
0.2
-
MtaA with substrate methylcob(III)-alamin, pH 7.0, 37°C
0.3
-
purified recombinant wild-type MtaA, pH 7.0, 37°C
0.5377
-
mtaC3B3A1 strain, cells grown on trimethylamine with tetracycline, pH 7.0, 37°C
0.5657
-
mtaC3B3A1 strain, cells grown on methanol with tetracycline, pH 7.0, 37°C
1.21
MT2 activity in recombinant Escherichia coli cells transfected with gene cmtA, pH 7.2, 37°C
2
-
purified Zn2+-containing holoenzyme, pH 7.0, 37°C
2.2
MT2 activity in cells grown on trimethylamine, pH 7.2, 37°C
5.5
-
purified recombinant enzyme, pH 7.2, 37°C
7.5
MT2 activity in cells grown on methanol, pH 7.2, 37°C
8
-
MtaA with substrate methylcob(III)inamide, 50 mM methylcob(III)inamide as substrate show an activity of 8 U/mg, approximately 40fold higher than with 50 mM methylcob(III)-alamin, pH 7.0, 37°C
additional information
-
specific activities of diverse mtaCBA transcripts from cells with different growth conditions, overview