2.1.1.247: [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase

This is an abbreviated version!
For detailed information about [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase, go to the full flat file.

Reaction

Synonyms

corrinoid:coenzyme M methyltransferase, methylated MtmC protein:CoM methyltransferase, methylated [methylamine-specific corrinoid protein]:coenzymeM methyltransferase, methylcobamide:coenzyme M methyltransferase, methylcobamide:CoM methyltransferase, methylcorrinoid:Coenzyme M methyltransferase, methylcorrinoid:CoM methyltransferase, methyltransferase 2, methyltransferase II, MMA-specific methyltransferase, MMA:CoM methyl transferase, MM_1070, MT2, MT2-A, MT2-M, mtaA, mtbA, TMA-specific methyltransferase, TMA:CoM methyl transferase, TMA:CoM methyltransferase, trimethylamine:coenzyme M methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.247 [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase

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Results	in table
3	Activating Compound
33	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
2	Expression
12	General Information
3	IC50 Value
4	Inhibitors
6	KM Value [mM]
4	Metals/Ions
2	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
17	Organism
5	Pathway
4	PDB ID
5	pH Optimum
2	Purification (Commentary)
2	Reaction
15	Reference
9	Source Tissue
4	Specific Activity [micromol/min/mg]
33	Substrates and Products (Substrate)
2	Subunits
48	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 2.1.1.247 - [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

a [methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) dimethylamine-specific corrinoid protein]

4 entries

a [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) methylamine-specific corrinoid protein]

4 entries

a [methyl-Co(III) monomethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) monomethylamine-specific corrinoid protein]

2 entries

a [methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) trimethylamine-specific corrinoid protein]

4 entries

HSCoM + methylcobalamin

CH3-SCoM + cob(I)alamin + H+

Methanosarcina barkeri

O30640

-

717753

-

-

r

[methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + [Co(I) dimethylamine-specific corrinoid protein]

Methanosarcina barkeri

O30640

isozyme MT2-A, not MT2-M

717753

-

-

r

[methyl-Co(III) monomethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + [Co(I) monomethylamine-specific corrinoid protein]

Methanosarcina barkeri

O30640

isozyme MT2-A, not MT2-M

717753

-

-

r

[methyl-Co(III) trimethylamine-specific corrinoid protein] + 3-mercaptopropionate

methyl-3-mercaptopropionate + [Co(I) trimethylamine-specific corrinoid protein]

Methanosarcina barkeri

O30640

3-mercaptopropionate is a coenzyme M analogue

717753

-

-

?

[methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + [Co(I) trimethylamine-specific corrinoid protein]

4 entries

additional information

?

-

8 entries

a [methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) dimethylamine-specific corrinoid protein]

Methanomethylovorans hollandica

-

-

736150

-

-

?

a [methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) dimethylamine-specific corrinoid protein]

Methanosarcina barkeri

-

-

717557, 717754

-

-

?

a [methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) dimethylamine-specific corrinoid protein]

Methanosarcina barkeri

O30640

-

736150

-

-

?

a [methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) dimethylamine-specific corrinoid protein]

Methanosarcina barkeri DSM 804

-

-

717557

-

-

?

a [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) methylamine-specific corrinoid protein]

Methanomethylovorans hollandica

-

-

736150

-

-

?

a [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) methylamine-specific corrinoid protein]

Methanosarcina barkeri

O30640

-

727831, 736150

-

-

?

a [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) methylamine-specific corrinoid protein]

Methanosarcina barkeri

O30640

binding analysis of CoM at the metal center of isozyme MT2-A, overview

717237

-

-

?

a [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) methylamine-specific corrinoid protein]

Methanosarcina barkeri

O30640

trimethylamine methyl transfer required, neither dimethylamine nor monomethylamine serve as substrate

717718

-

-

?

a [methyl-Co(III) monomethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) monomethylamine-specific corrinoid protein]

Methanosarcina barkeri

-

-

717557, 717754

-

-

?

a [methyl-Co(III) monomethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) monomethylamine-specific corrinoid protein]

Methanosarcina barkeri DSM 804

-

-

717557

-

-

?

a [methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) trimethylamine-specific corrinoid protein]

Methanomethylovorans hollandica

-

-

736150

-

-

?

a [methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) trimethylamine-specific corrinoid protein]

Methanosarcina barkeri

-

-

717557, 717754

-

-

?

a [methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) trimethylamine-specific corrinoid protein]

Methanosarcina barkeri

O30640

-

736150

-

-

?

a [methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + a [Co(I) trimethylamine-specific corrinoid protein]

Methanosarcina barkeri DSM 804

-

-

717557

-

-

?

[methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + [Co(I) trimethylamine-specific corrinoid protein]

Methanosarcina barkeri

-

-

717162

-

-

?

[methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + [Co(I) trimethylamine-specific corrinoid protein]

Methanosarcina barkeri

O30640

heterolytic cleavage of the methylcobamide carbon-cobalt bond with cob(I)alamin as the major product of the reaction

717753

-

-

r

[methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + [Co(I) trimethylamine-specific corrinoid protein]

Methanosarcina barkeri

O30640

isozymes MT2-A and MT2-M, heterolytic cleavage of the methylcobamide carbon-cobalt bond with cob(I)alamin as the major product of the reaction

717753

-

-

r

[methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M

methyl-CoM + [Co(I) trimethylamine-specific corrinoid protein]

Methanosarcina barkeri NaT1

-

-

717162

-

-

?

additional information

?

-

Methanosarcina barkeri

O30640

corrinoid proteins mediating CoM methylation from dimethylamine or monomethylamine have a specific requirement for MT2-A, reconstitution of trimethylamine-dependent coenzyme M methylation, overview. Trimethylamine methyl transfer can interact with either isozyme of MT2 but has the greatest affinity for the A isozyme. The predominant isozyme of MT2 from in TMA-grown cells is the favored participant in the TMA:CoM methyl transfer reaction

717718

-

-

?

additional information

?

-

Methanosarcina barkeri

-

corrinoid proteins mediating CoM methylation from dimethylamine or monomethylamine have a specific requirement for MT2-A, reconstitution of trimethylamine-dependent coenzyme M methylation, overview. Trimethylamine methyl transfer can interact with either isozyme of MT2 but has the greatest affinity for the A isozyme. The predominant isozyme of MT2 from in TMA-grown cells is the favored participant in the TMA:CoM methyl transfer reaction

717718

-

-

?

additional information

?

-

Methanosarcina barkeri

O30640

methylamine-dependent methylation of CoM mediated by trimethyamine- or monomethylamine-specific methyltransferases derived from cells grown on trimethylamine. Methylation of CoM by trimethylamine and methylation by monomethylamine are mediated by separate enzyme systems with at least one different component

717713

-

-

?

additional information

?

-

Methanosarcina barkeri

O30640

conversions of monomethylamine and dimethylamine to CH3-SCoM are dependent upon MT2-A, and are not supported by MT2-M, both isozymes catalyze S-methylation of 2-thioethanesulfonate, i.e. coenzyme M, and exhibit similar apparent Km values for coenzyme M, isozymes substrate specificities, overview

717753

-

-

?

additional information

?

-

Methanosarcina barkeri

-

the enzyme exhibits MT2 activity, the MT2 activity is measured by following the coenzyme-M-dependent demethylation of methylcobalamin

717162

-

-

?

additional information

?

-

Methanosarcina barkeri

O30640

the enzyme exhibits MT2 activity, the MT2 activity is measured by following the coenzyme-M-dependent demethylation of methylcobalamin. Trimethylammonium:coenzyme M methyltransferase activity detected by coenzyme M methylation

717237

-

-

?

additional information

?

-

Methanosarcina barkeri MS / DSM 800

O30640

methylamine-dependent methylation of CoM mediated by trimethyamine- or monomethylamine-specific methyltransferases derived from cells grown on trimethylamine. Methylation of CoM by trimethylamine and methylation by monomethylamine are mediated by separate enzyme systems with at least one different component

717713

-

-

?

additional information

?

-

Methanosarcina barkeri NaT1

-

the enzyme exhibits MT2 activity, the MT2 activity is measured by following the coenzyme-M-dependent demethylation of methylcobalamin

717162

-

-

?