2.1.1.248: methylamine-corrinoid protein Co-methyltransferase
This is an abbreviated version!
For detailed information about methylamine-corrinoid protein Co-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.248
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2.1.1.248
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methanosarcina
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barkeri
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methyltransferases
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pyrrolysine
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amber
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methanogenesis
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methanogen
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in-frame
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trnapyl
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dimethylamine
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acetivorans
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pyrrolysyl-trna
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aminoacylated
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lysyl-trna
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dimethylarsinic
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synthetases
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arsenite
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monomethylarsonate
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lysrs1
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selenocysteine
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pylts
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synthetase-like
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methylarsonic
- 2.1.1.248
- methanosarcina
- barkeri
- methyltransferases
- pyrrolysine
-
amber
-
methanogenesis
-
methanogen
-
in-frame
- trnapyl
- dimethylamine
- acetivorans
-
pyrrolysyl-trna
-
aminoacylated
- lysyl-trna
-
dimethylarsinic
- synthetases
- arsenite
- monomethylarsonate
- lysrs1
- selenocysteine
-
pylts
-
synthetase-like
-
methylarsonic
Reaction
Synonyms
corrinoid-dependent methylamine methyltransferase, MMA methyltransferase, MMA:CoM methyltransferase, MMA:MMCP methyltransferase, MMAMT, monomethylamine methyltransferase, monomethylamine:coenzyme M methyl transferase, monomethylamine:MMCP methyltransferase, MtmB, mtmB1, mtmB2
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Substrates Products
Substrates Products on EC 2.1.1.248 - methylamine-corrinoid protein Co-methyltransferase
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REACTION DIAGRAM
methylamine + a [Co(I) methylamine-specific corrinoid protein]
a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
additional information
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model for MtmB methylation of Co(I) corrinoid cofactor with monomethylamine. Y335 and Q333 are proposed to assist in the initial MtmB binding of monomethylamine and positioning such that electrophilic attack of the C-2 atom on the lone electron pair of the nitrogen of unionized monomethylamine occurs. The residues can also serve to H-bond with the ammonia released from the pyrroline ring, enhancing the equilibrium between 2-aminopyrrolysine and pyrrolysine in the direction of product removal from the enzyme, model of pyrrolysine function
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-
?
a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
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-
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-
?
methylamine + a [Co(I) methylamine-specific corrinoid protein]
a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
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-
-
?
methylamine + a [Co(I) methylamine-specific corrinoid protein]
a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
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-
-
?
methylamine + a [Co(I) methylamine-specific corrinoid protein]
a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
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catalytic cycle of MMA:CoM methyl transfer, overview
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-
?
methylamine + a [Co(I) methylamine-specific corrinoid protein]
a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
the methylamine-specific corrinoid protein MtmC cycles between methyl-Co(III)- and Co(I)-MtmC during catalysis. Methanogen methylotrophic corrinoid proteins such as MtmC are methylated in the Co(I) state, forming a hexacoordinate methyl-Co(III) species whose demethylation regenerates Co (I) corrinoid. Pyrrolysine in MtmB mediates methylation of MtmC
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-
?
methylamine + a [Co(I) methylamine-specific corrinoid protein]
a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
Methanosarcina barkeri MS / DSM 800
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-
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?
methylamine + a [Co(I) methylamine-specific corrinoid protein]
a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
-
-
-
-
?
methylamine + a [Co(I) methylamine-specific corrinoid protein]
a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
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-
-
-
?