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2.1.1.248: methylamine-corrinoid protein Co-methyltransferase

This is an abbreviated version!
For detailed information about methylamine-corrinoid protein Co-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.248

Reaction

methylamine
+
a [Co(I) methylamine-specific corrinoid protein]
=
a [methyl-Co(III) methylamine-specific corrinoid protein]
+
NH3

Synonyms

corrinoid-dependent methylamine methyltransferase, MMA methyltransferase, MMA:CoM methyltransferase, MMA:MMCP methyltransferase, MMAMT, monomethylamine methyltransferase, monomethylamine:coenzyme M methyl transferase, monomethylamine:MMCP methyltransferase, MtmB, mtmB1, mtmB2

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.248 methylamine-corrinoid protein Co-methyltransferase

Substrates Products

Substrates Products on EC 2.1.1.248 - methylamine-corrinoid protein Co-methyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
methylamine + a [Co(I) methylamine-specific corrinoid protein]
a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
show the reaction diagram
additional information
?
-
model for MtmB methylation of Co(I) corrinoid cofactor with monomethylamine. Y335 and Q333 are proposed to assist in the initial MtmB binding of monomethylamine and positioning such that electrophilic attack of the C-2 atom on the lone electron pair of the nitrogen of unionized monomethylamine occurs. The residues can also serve to H-bond with the ammonia released from the pyrroline ring, enhancing the equilibrium between 2-aminopyrrolysine and pyrrolysine in the direction of product removal from the enzyme, model of pyrrolysine function
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