2.1.1.250: trimethylamine-corrinoid protein Co-methyltransferase

This is an abbreviated version!
For detailed information about trimethylamine-corrinoid protein Co-methyltransferase, go to the full flat file.

Reaction

Synonyms

DSY3156 protein, glycine betaine:cob(I)alamin methyltransferase, MMA methyltransferase 1, MMA methyltransferase 2, MtgB, MttB, mttB1C1, mttB2C2, MV8460, MV8460 GB:cob(I)alamin, non-pyrrolysine MttB homolog, nonpyrrolysine MttB homolog, TMA methyltransferase, TMA:CoM methyltransferase, trimethylamine methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.250 trimethylamine-corrinoid protein Co-methyltransferase

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Results	in table
1	Activating Compound
182	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
6	Expression
20	General Information
2	Localization
1	Metals/Ions
1	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
14	Organism
3	Pathway
1	pH Optimum
2	Protein Variants
1	Purification (Commentary)
1	Reaction
12	Reference
3	Source Tissue
20	Substrates and Products (Substrate)
3	Subunits
44	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Natural Substrates Products

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of the Enzyme Summary Page.

Natural Substrates Products on EC 2.1.1.250 - trimethylamine-corrinoid protein Co-methyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

trimethylamine + a [Co(I) methylamine-specific corrinoid protein]

a [methyl-Co(III) methylamine-specific corrinoid protein] + dimethylamine

Methanosarcina barkeri

O93658

-

717525, 717781

-

-

?

trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein]

a [methyl-Co(III) methylamine-specific corrinoid protein] + dimethylamine

2 entries

trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein]

a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine

7 entries

additional information

?

-

3 entries

trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein]

a [methyl-Co(III) methylamine-specific corrinoid protein] + dimethylamine

Methanosarcina barkeri

O93658

-

717771

-

-

?

trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein]

a [methyl-Co(III) methylamine-specific corrinoid protein] + dimethylamine

Methanosarcina barkeri MS / DSM 800

O93658

-

717771

-

-

?

trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein]

a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine

Methanolobus vulcani

-

-

756781

-

-

?

trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein]

a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine

Methanolobus vulcani B1

-

-

756781

-

-

?

trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein]

a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine

Methanolobus vulcani B1d

-

-

756781

-

-

?

trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein]

a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine

Methanosarcina barkeri

O93658

-

717721

-

-

?

trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein]

a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine

Methanosarcina mazei

P58973, P58974

-

717723

-

-

?

trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein]

a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine

Methanosarcina mazei Goe1

P58973, P58974

-

717723

-

-

?

trimethylamine + a [Co(I) trimethylamine-specific corrinoid protein]

a [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine

Methanosarcina thermophila

Q9P995

-

717721

-

-

?

additional information

?

-

Desulfitobacterium hafniense

Q24MI2

ability of the recombinant DSY3156 protein to methylate cob(I)alamin with various substrates. Quaternary amines such as carnitine and choline do not serve as substrates, nor do tertiary amines such as dimethylglycine or trimethylamine. Instead, DSY3156 protein carries out a robust methylation of cob(I)alamin in the presence of glycine betaine

737168

-

-

?

additional information

?

-

Desulfitobacterium hafniense

-

ability of the recombinant DSY3156 protein to methylate cob(I)alamin with various substrates. Quaternary amines such as carnitine and choline do not serve as substrates, nor do tertiary amines such as dimethylglycine or trimethylamine. Instead, DSY3156 protein carries out a robust methylation of cob(I)alamin in the presence of glycine betaine

737168

-

-

?

additional information

?

-

Desulfitobacterium hafniense Y51

Q24MI2

ability of the recombinant DSY3156 protein to methylate cob(I)alamin with various substrates. Quaternary amines such as carnitine and choline do not serve as substrates, nor do tertiary amines such as dimethylglycine or trimethylamine. Instead, DSY3156 protein carries out a robust methylation of cob(I)alamin in the presence of glycine betaine

737168

-

-

?