2.1.1.250: trimethylamine-corrinoid protein Co-methyltransferase

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For detailed information about trimethylamine-corrinoid protein Co-methyltransferase, go to the full flat file.

Reaction

Synonyms

DSY3156 protein, glycine betaine:cob(I)alamin methyltransferase, MMA methyltransferase 1, MMA methyltransferase 2, MtgB, MttB, mttB1C1, mttB2C2, MV8460, MV8460 GB:cob(I)alamin, non-pyrrolysine MttB homolog, nonpyrrolysine MttB homolog, TMA methyltransferase, TMA:CoM methyltransferase, trimethylamine methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.250 trimethylamine-corrinoid protein Co-methyltransferase

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Results	in table
1	Activating Compound
182	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
6	Expression
20	General Information
2	Localization
1	Metals/Ions
1	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
14	Organism
3	Pathway
1	pH Optimum
2	Protein Variants
1	Purification (Commentary)
1	Reaction
12	Reference
3	Source Tissue
20	Substrates and Products (Substrate)
3	Subunits
44	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.1.1.250 - trimethylamine-corrinoid protein Co-methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

trimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase

The enzyme, which catalyses the transfer of a methyl group from trimethylamine to a trimethylamine-specific corrinoid protein (MttC), is involved in methanogenesis from trimethylamine. The enzyme contains the unusual amino acid pyrrolysine [2]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase.