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2.1.1.254: erythromycin 3''-O-methyltransferase

This is an abbreviated version!
For detailed information about erythromycin 3''-O-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
erythromycin C
=
S-adenosyl-L-homocysteine
+
erythromycin A

Synonyms

EryG

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.254 erythromycin 3''-O-methyltransferase

Cloned

Cloned on EC 2.1.1.254 - erythromycin 3''-O-methyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
introduction of additional eryK and eryG genes into Saccharopolyspora erythraea shows significant impacts on their transcription levels and enhances the biotransformation process from erythromycin D to erythromycin A with gene dose effects. At the eryK/eryG copy number ratio of 3:2 as well as their resultant transcript ratio of around 2.5:1 to 3.0:1, erythromycin B and erythromycin C are nearly completely eliminated and accordingly converted to erythromycin A