2.1.1.254: erythromycin 3''-O-methyltransferase
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Reaction
Synonyms
EryG
ECTree
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Cloned
Cloned on EC 2.1.1.254 - erythromycin 3''-O-methyltransferase
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introduction of additional eryK and eryG genes into Saccharopolyspora erythraea shows significant impacts on their transcription levels and enhances the biotransformation process from erythromycin D to erythromycin A with gene dose effects. At the eryK/eryG copy number ratio of 3:2 as well as their resultant transcript ratio of around 2.5:1 to 3.0:1, erythromycin B and erythromycin C are nearly completely eliminated and accordingly converted to erythromycin A