2.1.1.254: erythromycin 3''-O-methyltransferase
This is an abbreviated version!
For detailed information about erythromycin 3''-O-methyltransferase, go to the full flat file.
Reaction
Synonyms
EryG
ECTree
2.1.1.254 erythromycin 3''-O-methyltransferaseAdvanced search results
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General Information on EC 2.1.1.254 - erythromycin 3''-O-methyltransferase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
malfunction
physiological function
the enzyme catalyzes all of the 3''-O-methylation reactions of the erythromycin biosynthetic pathway in Saccharopolyspora erythraea
malfunction
disruption of the transcription unit, herein designated eryG, by insertion of an integrational plasmid vector, causes a block at the terminal step in the biosynthesis of erythromycin, the conversion of erythromycin C to A by 0-methylation
malfunction
eryG mutant strain lacks detectable erythromycin O-methyltransferase activity with erythromycin C, erythromycin D, or the analogs 2-norerythromycin C and 2-norerythromycin D as substrates
malfunction
the eryG mutation affects the conversion of L-mycarose to L-cladinose
