2.1.1.272: cobalt-factor III methyltransferase
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For detailed information about cobalt-factor III methyltransferase, go to the full flat file.
Reaction
Synonyms
CbiH60, Precorrin-3 methylase
ECTree
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Systematic Name
Systematic Name on EC 2.1.1.272 - cobalt-factor III methyltransferase
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S-adenosyl-L-methionine:cobalt-factor III 17-methyltransferase (ring contracting)
Isolated from the bacterium Bacillus megaterium. The enzyme, which participates in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses a crucial reaction where the tetrapyrrole ring contracts as a result of methylation of C-17. Contains a [4Fe-4S] cluster. It can also convert cobalt-precorrin-3 to cobalt-precorrin-4. The reductant may be thioredoxin. See EC 2.1.1.131, precorrin-3B C17-methyltransferase, for the corresponding enzyme that participates in the aerobic cobalamin biosynthesis pathway.