2.1.1.280: selenocysteine Se-methyltransferase
This is an abbreviated version!
For detailed information about selenocysteine Se-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.280
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2.1.1.280
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selenium
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selenate
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astragalus
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se-methylselenocysteine
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hyperaccumulator
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bisulcatus
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brassica
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oleracea
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mesecys
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homocysteine
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methylselenocysteine
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phytoremediation
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sulfurylase
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non-accumulating
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broccoli
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mustard
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agriculture
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juncea
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italica
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brassicaceae
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organoselenium
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s-methylmethionine
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nonprotein
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chemopreventative
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biofortification
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synthesis
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fabaceae
- 2.1.1.280
- selenium
- selenate
- astragalus
- se-methylselenocysteine
-
hyperaccumulator
- bisulcatus
-
brassica
- oleracea
-
mesecys
- homocysteine
-
methylselenocysteine
-
phytoremediation
-
sulfurylase
-
non-accumulating
- broccoli
- mustard
- agriculture
- juncea
- italica
- brassicaceae
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organoselenium
- s-methylmethionine
-
nonprotein
-
chemopreventative
-
biofortification
- synthesis
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fabaceae
Reaction
Synonyms
BjSMT, BoSMT, Hcy methyltransferase, SEcMT, SeCys-methyltransferase, SeCys-MT, selenocysteine methyltransferase, SMT, smtA, YagD, YagD protein
ECTree
2.1.1.280 selenocysteine Se-methyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.1.1.280 - selenocysteine Se-methyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
DL-selenocysteine + S-adenosyl-L-methionine
Se-methyl-selenocysteine + S-adenosyl-L-homocysteine
the stereochemical orientation of the alpha-amino group is not crucial. With DL-selenocysteine or DL-selenohomocysteine as substrates, the Km decreases. This leads to the overproportional increase of specific activity with DL-selenocysteine
-
-
?
L-selenocysteine + S-adenosyl-L-methionine
Se-methyl-L-selenocysteine + S-adenosyl-L-homocysteine
the enzyme is suitable for specific detoxification of selenocysteine and preventing selenium from intrusion into downstream sulfur pathways. Plays a crucial role in conferring selenium tolerance
-
-
?
S-adenosyl-L-methionine + 4-thiobutyric acid
S-adenosyl-L-homocysteine + 4-methylthiobutyric acid
0.014% relative activity compared to activity with L-homocysteine set at 100%
-
-
?
S-adenosyl-L-methionine + D-homocysteine
?
16% relative activity compared to activity with L-homocysteine set at 100%
-
-
?
S-adenosyl-L-methionine + L-cysteine
S-methyl-L-cysteine + S-adenosyl-L-homocysteine
1% relative activity with 10 mM L-cysteine compared to 1 mM L-selenocysteine activity set at 100%
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-
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
no activity with wild-type enzyme. A184T mutant enzyme gains the ability to methylate L-homocysteine
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-
?
S-adenosyl-L-methionine + L-homoserine
?
less than 0.003% relative activity compared to activity with L-homocysteine set at 100%
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-
?
S-adenosyl-L-methionine + L-selenocysteine
S-adenosyl-L-homocysteine + Se-methyl-L-selenocysteine
S-adenosyl-L-methionine + L-selenocysteine
Se-methyl-L-selenocysteine + S-adenosyl-L-homocysteine
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-
-
?
S-adenosyl-L-methionine + selenocysteamine
?
less than 1% relative activity with 1 mM selenocysteamine compared to 1 mM L-selenocysteine activity set at 100%
-
-
?
S-methyl-L-methionine + L-homocysteine
L-methionine + S-methyl-L-homocysteine
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-
-
-
?
S-adenosyl-L-methionine + DL-homocysteine
?
less than 1% relative activity with 10 mM DL-homocysteine compared to activity with 1 mM DL-selenocysteine set at 100%
-
-
?
S-adenosyl-L-methionine + DL-homocysteine
?
93% relative activity compared to activity with L-homocysteine set at 100%
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-
?
S-adenosyl-L-methionine + DL-selenocysteine
?
475% relative activity with 1 mM DL-selenocysteine compared to 1 mM L-selenocysteine activity set at 100%
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-
?
S-adenosyl-L-methionine + DL-selenocysteine
?
highest preference as methyl acceptor
-
-
?
S-adenosyl-L-methionine + DL-selenohomocysteine
?
25% relative activity with 1 mM DL-selenohomocysteine compared to activity with 1 mM DL-selenocysteine set at 100%
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-
?
S-adenosyl-L-methionine + DL-selenohomocysteine
?
213% relative activity compared to activity with L-homocysteine set at 100%
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-
?
S-adenosyl-L-methionine + L-cysteine
S-adenosyl-L-homocysteine + S-methyl-L-cysteine
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-
-
?
S-adenosyl-L-methionine + L-cysteine
S-adenosyl-L-homocysteine + S-methyl-L-cysteine
less than 0.003% relative activity compared to activity with L-homocysteine set at 100%
-
-
?
S-adenosyl-L-methionine + L-selenocysteine
S-adenosyl-L-homocysteine + Se-methyl-L-selenocysteine
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-
-
?
S-adenosyl-L-methionine + L-selenocysteine
S-adenosyl-L-homocysteine + Se-methyl-L-selenocysteine
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-
-
-
?
S-adenosyl-L-methionine + L-selenocysteine
S-adenosyl-L-homocysteine + Se-methyl-L-selenocysteine
S-adenosyl-L-methionine at intracellular concentrations cannot serve as an effective substrate for the enzyme
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-
?
S-adenosyl-L-methionine + L-selenocysteine
S-adenosyl-L-homocysteine + Se-methyl-L-selenocysteine
selenate-treated plants synthesize significantly more Se-methyl-L-selenocysteine
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-
?
S-adenosyl-L-methionine + L-selenocysteine
S-adenosyl-L-homocysteine + Se-methyl-L-selenocysteine
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-
-
?
S-adenosyl-L-methionine + L-selenocysteine
S-adenosyl-L-homocysteine + Se-methyl-L-selenocysteine
0.027% relative activity compared to activity with L-homocysteine set at 100%
-
-
?
S-methyl-L-methionine + L-selenocysteine
L-methionine + Se-methyl-L-selenocysteine
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-
-
?
S-methyl-L-methionine + L-selenocysteine
L-methionine + Se-methyl-L-selenocysteine
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-
-
-
?
S-methyl-L-methionine + L-selenocysteine
L-methionine + Se-methyl-L-selenocysteine
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-
-
?
S-methyl-L-methionine + L-selenocysteine
L-methionine + Se-methyl-L-selenocysteine
S-methylmethionine is the physiological methyl group donor. The enzyme is involved in detoxification of selenium in selenium-accumulating plants
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-
?
S-methyl-L-methionine + L-selenocysteine
L-methionine + Se-methyl-L-selenocysteine
activity with S-methyl-L-methionine is higher than with S-adenosyl-L-methionine
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-
?
S-methyl-L-methionine + L-selenocysteine
L-methionine + Se-methyl-L-selenocysteine
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-
-
?
S-methyl-L-methionine + L-selenocysteine
L-methionine + Se-methyl-L-selenocysteine
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-
-
-
?
S-methyl-L-methionine + L-selenocysteine
L-methionine + Se-methyl-L-selenocysteine
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-
-
?
S-methyl-L-methionine + L-selenocysteine
L-methionine + Se-methyl-L-selenocysteine
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-
-
?
S-methyl-L-methionine + L-selenocysteine
L-methionine + Se-methyl-L-selenocysteine
S-methylmethionine is the physiological methyl group donor
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-
?
S-methyl-L-methionine + L-selenocysteine
L-methionine + Se-methyl-L-selenocysteine
activity with S-methyl-L-methionine is higher than with S-adenosyl-L-methionine
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-
?
additional information
?
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methylation of L-cysteine can not be detected unless the concentration is raised to 10 mM. Under this condition, the reaction velocity is approximately 1% compared with methylation of L-selenocysteine. No activity with selenocysteamine and DL-homocysteine
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-
?
additional information
?
-
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the plant produces methylselenocysteine from selenocysteine
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-
?
additional information
?
-
-
no activity with trimethylsulfonium and glycine betaine as methyl donor
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-
?
additional information
?
-
no activity with trimethylsulfonium and glycine betaine as methyl donor
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-
?
additional information
?
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expression of BoSMT significantly enhances Se tolerance with an increased level of total Se accumulation in Escherichia coli
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-
?
additional information
?
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the enzyme also catalyzes the reaction of EC 2.1.1.10
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-
?
additional information
?
-
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the enzyme also catalyzes the reaction of EC 2.1.1.10
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-
?
additional information
?
-
no activity with trimethylsulfonium and glycine betaine as methyl donor
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-
?
additional information
?
-
-
no activity with trimethylsulfonium and glycine betaine as methyl donor
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-
?
additional information
?
-
-
the plant produces methylselenocysteine from selenocysteine
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-
?
additional information
?
-
-
the plant produces methylselenocysteine from selenocysteine
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-
?
