Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.1.1.292: carminomycin 4-O-methyltransferase

This is an abbreviated version!
For detailed information about carminomycin 4-O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.292

Reaction

S-adenosyl-L-methionine
+
carminomycin
=
S-adenosyl-L-homocysteine
+
daunorubicin

Synonyms

4-O-methyltransferase, anthracycline 4-O-methyltransferase, anthracycline methyltransferase, carminomycin 4-OMT, class I methyltransferase, COMT, DauK, DnrK

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.292 carminomycin 4-O-methyltransferase

Reference

Reference on EC 2.1.1.292 - carminomycin 4-O-methyltransferase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Miyamoto, Y.; Ohta, S.; Johdo, O.; Nagamatsu, Y.; Yoshimoto, A.
Production of a new hybrid anthracycline 4-O-methylepelmycin by heterologous expression of dnrK in epelmycin-producing Streptomyces violaceus
J. Antibiot.
53
828-836
2000
Streptomyces peucetius
Manually annotated by BRENDA team
Madduri, K.; Torti, F.; Colombo, A.L.; Hutchinson, C.R.
Cloning and sequencing of a gene encoding carminomycin 4-O-methyltransferase from Streptomyces peucetius and its expression in Escherichia coli
J. Bacteriol.
175
3900-3904
1993
Streptomyces peucetius (Q06528), Streptomyces peucetius
Manually annotated by BRENDA team
Madduri, K.; Hutchinson, C.R.
Functional characterization and transcriptional analysis of a gene cluster governing early and late steps in daunorubicin biosynthesis in Streptomyces peucetius
J. Bacteriol.
177
3879-3884
1995
Streptomyces peucetius (Q06528)
Manually annotated by BRENDA team
Dickens, M.L.; Ye, J.; Strohl, W.R.
Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5
J. Bacteriol.
177
536-543
1995
Streptomyces sp. (Q55216)
Manually annotated by BRENDA team
Dickens, M.L.; Priestley, N.D.; Strohl, W.R.
In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA
J. Bacteriol.
179
2641-2650
1997
Streptomyces sp.
Manually annotated by BRENDA team
Jansson, A.; Koskiniemi, H.; Mäntsälä, P.; Niemi, J.; Schneider, G.
Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products
J. Biol. Chem.
279
41149-41156
2004
Streptomyces peucetius (Q06528), Streptomyces peucetius
Manually annotated by BRENDA team
Connors, N.C.; Bartel, P.L.; Strohl, W.R.
Biosynthesis of anthracyclines: carminomycin 4-0-methyltransferase, the terminal enzymic step in the formation of daunomycin
J. Gen. Microbiol.
136
1895-1898
1990
Streptomyces sp. (Q55216)
-
Manually annotated by BRENDA team
Connors, N.C.; Strohl, W.R.
Partial purification and properties of carminomycin 4-0-methyltransferase from Streptomyces sp. strain C5
J. Gen. Microbiol.
139
1353-1362
1993
Streptomyces sp.
-
Manually annotated by BRENDA team
Huber, T.; Wang, F.; Singh, S.; Johnson, B.; Zhang, J.; Sunkara, M.; Van Lanen, S.; Morris, A.; Phillips, G.; Thorson, J.
Functional AdoMet isosteres resistant to classical AdoMet degradation pathways
ACS Chem. Biol.
11
2484-2491
2016
Streptomyces peucetius (Q06528)
Manually annotated by BRENDA team
Grocholski, T.; Yamada, K.; Sinkkonen, J.; Tirkkonen, H.; Niemi, J.; Metsae-Ketelae, M.
Evolutionary trajectories for the functional diversification of anthracycline methyltransferases
ACS Chem. Biol.
14
850-856
2019
Streptomyces peucetius (Q06528)
Manually annotated by BRENDA team
Grocholski, T.; Dinis, P.; Niiranen, L.; Niemi, J.; Metsae-Ketelae, M.
Divergent evolution of an atypical S-adenosyl-L-methionine-dependent monooxygenase involved in anthracycline biosynthesis
Proc. Natl. Acad. Sci. USA
112
9866-9871
2015
Streptomyces peucetius (Q06528)
Manually annotated by BRENDA team