2.1.1.293: 6-hydroxytryprostatin B O-methyltransferase

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For detailed information about 6-hydroxytryprostatin B O-methyltransferase, go to the full flat file.

Reaction

Synonyms

ftmD

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.293 6-hydroxytryprostatin B O-methyltransferase

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Results	in table
3	AA Sequence
2	Cloned(Commentary)
1	Cofactor
1	General Information
4	kcat/KM [mM/s]
4	KM Value [mM]
1	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
3	Organism
6	Pathway
1	pH Optimum
1	pH Range
3	Protein Variants
1	Purification (Commentary)
1	Reaction
3	Reference
3	Substrates and Products (Substrate)
2	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Turnover Number [1/s]

General Information

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General Information on EC 2.1.1.293 - 6-hydroxytryprostatin B O-methyltransferase

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evolution

Aspergillus fumigatus

Q4WAW6

all ftm genes are expressed almost equally well in both Af293 and BM939 strains. But a point mutation found in ftmD in the genome of Af293 causes an arginine to leucine substitution at position 202 of FtmD, resulting in a dramatic decrease of the catalytic efficiency of FtmD. This mutated form of FtmD appeared not functioning under physiological conditions in Af293 to produce any detectable levels of TPS-A or any downstream metabolites

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