2.1.1.296: methyltransferase cap2
This is an abbreviated version!
For detailed information about methyltransferase cap2, go to the full flat file.
Reaction
Synonyms
AFT, cap2, cap2-MTase, CMTr2, FLJ11171, FTSJD1, hMTr2, mRNA (nucleoside-2'-O)-methyltransferase, MT48, MT57, MTR2, TbMT48, TbMT57
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Natural Substrates Products on EC 2.1.1.296 - methyltransferase cap2
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REACTION DIAGRAM
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA]
S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA]
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA]
S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA]
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S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA]
S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA]
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hMTr2 protein transfers a methyl group from S-adenosylmethionine to the 2'-O-ribose of the second nucleotide of messenger RNA and small nuclear RNA
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additional information
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hMTr2 protein transfers a methyl group from S-adenosylmethionine to the 2'-O-ribose of the second nucleotide of messenger RNA and small nuclear RNA
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additional information
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a conventional 5'-terminal structure of eukaryotic mRNAs consists of a 7-methylguanosine (m7G) moiety linked to the first transcribed nucleotide by a 5' to 5' triphosphate bridge resulting in the structure m7GpppN, which is referred to as cap 0, and most often the first and second transcribed nucleotide carry 2'-O-methyl groups (cap 1 and cap 2 structures, respectively). The cap2 methyltransferase, EC 2.1.1.296 transfers the methyl group to the second nucleotide. In contrast, four nucleotides adjacent to the m7G cap are methylated at the SL RNA 5' end to generate a cap 4 structure: m7G-ppp-N6,N6,2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3,2'-O-methyluridine. The cap 4 structure seems to be restricted to the family Trypanosomatidae
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