2.1.1.296: methyltransferase cap2

This is an abbreviated version!
For detailed information about methyltransferase cap2, go to the full flat file.

Word Map on EC 2.1.1.296

2.1.1.296

c-mannosylation

mannose

neuroblast

thrombospondin

2'-o-ribose

r-spondin1

methyltransferases

netrin

Reaction

a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-(ribonucleotide)-[mRNA]

a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA]

Synonyms

AFT, cap2, cap2-MTase, CMTr2, FLJ11171, FTSJD1, hMTr2, mRNA (nucleoside-2'-O)-methyltransferase, MT48, MT57, MTR2, TbMT48, TbMT57

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.296 methyltransferase cap2

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Results	in table
2	Activating Compound
1299	AA Sequence
5	Cloned(Commentary)
3	Cofactor
2	Disease/ Diagnostics
1	Expression
14	General Information
4	Localization
2	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
5	Organism
1	Pathway
4	PDB ID
13	Protein Variants
1	Reaction
5	Reference
3	Source Tissue
7	Substrates and Products (Substrate)
3	Subunits
17	Synonyms
1	Systematic Name

Reference

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Reference on EC 2.1.1.296 - methyltransferase cap2

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677099

Arhin, G.K.; Li, H.; Ullu, E.; Tschudi, C.

A protein related to the vaccinia virus cap-specific methyltransferase VP39 is involved in cap 4 modification in Trypanosoma brucei

RNA

53-62

2006

Trypanosoma brucei (Q38DJ3)

16301606

728268

Arhin, G.; Ullu, E.; Tschudi, C.

2'-O-Methylation of position 2 of the trypanosome spliced leader cap 4 is mediated by a 48 kDa protein related to vaccinia virus VP39

Mol. Biochem. Parasitol.

147

137-139

2006

Trypanosoma brucei (Q385S9)

16516986

728390

Werner, M.; Purta, E.; Kaminska, K.; Cymerman, I.; Campbell, D.; Mittra, B.; Zamudio, J.; Sturm, N.; Jaworski, J.; Bujnicki, J.

2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family

Nucleic Acids Res.

4756-4768

2011

Homo sapiens (Q8IYT2), Homo sapiens

21310715

736863

Smietanski, M.; Werner, M.; Purta, E.; Kaminska, K.; Stepinski, J.; Darzynkiewicz, E.; Nowotny, M.; Bujnicki, J.

Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation

Nat. Commun.

3004

2014

Homo sapiens (Q8IYT2), Homo sapiens

24402442

756633

Sun, J.; Zhao, Y.; McGreal, R.; Cohen-Tayar, Y.; Rockowitz, S.; Wilczek, C.; Ashery-Padan, R.; Shechter, D.; Zheng, D.; Cvekl, A.

Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers

Epigenetics Chromatin

2016

Mus musculus (Q9CYT6)

27617035