2.1.1.303: 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase
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For detailed information about 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase, go to the full flat file.
Reaction
Synonyms
NcsB1
ECTree
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Systematic Name
Systematic Name on EC 2.1.1.303 - 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase
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S-adenosyl-L-methionine:2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase
The enzyme from the bacterium Streptomyces carzinostaticus is involved in the biosynthesis of 2-hydroxy-7-methoxy-5-methyl-1-naphthoate. This compound is part of the enediyne chromophore of the antitumor antibiotic neocarzinostatin. In vivo the enzyme catalyses the regiospecific methylation at the 7-hydroxy group of its native substrate 2,7-dihydroxy-5-methyl-1-naphthoate. In vitro it also recognizes other dihydroxynaphthoic acids and catalyses their regiospecific O-methylation.