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2.1.1.308: cytidylyl-2-hydroxyethylphosphonate methyltransferase

This is an abbreviated version!
For detailed information about cytidylyl-2-hydroxyethylphosphonate methyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate}
+
reduced acceptor
=
S-adenosyl-L-homocysteine
+
5'-deoxyadenosine
+
L-methionine
+
cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate}
+
oxidized acceptor

Synonyms

(S)-2-hydroxyethylphosphonate methylase, 2-hydroxyethylphosphonate methyltransferase, fom3, methyltransferase fom3

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.308 cytidylyl-2-hydroxyethylphosphonate methyltransferase

Reference

Reference on EC 2.1.1.308 - cytidylyl-2-hydroxyethylphosphonate methyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Woodyer, R.D.; Shao, Z.; Thomas, P.M.; Kelleher, N.L.; Blodgett, J.A.; Metcalf, W.W.; van der Donk, W.A.; Zhao, H.
Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster
Chem. Biol.
13
1171-1182
2006
Streptomyces fradiae (D2SNF5)
Manually annotated by BRENDA team
Woodyer, R.D.; Li, G.; Zhao, H.; van der Donk, W.A.
New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin
Chem. Commun. (Camb. )
4
359-361
2007
Streptomyces fradiae (D2SNF5)
Manually annotated by BRENDA team
Booker, S.J.
Anaerobic functionalization of unactivated C-H bonds
Curr. Opin. Chem. Biol.
13
58-73
2009
Streptomyces fradiae (D2SNF5)
Manually annotated by BRENDA team
Kuzuyama, T.; Hidaka, T.; Kamigiri, K.; Imai, S.; Seto, H.
Studies on the biosynthesis of fosfomycin. 4. The biosynthetic origin of the methyl group of fosfomycin
J. Antibiot.
45
1812-1814
1992
Streptomyces wedmorensis (Q56184)
Manually annotated by BRENDA team
Hammerschmidt, F.
Biosynthesis of natural products with a P-C bond. Part 8: on the origin of the oxirane oxygen atom of fosfomycin in Streptomyces fradiae
J. Chem. Soc. Perkin Trans.
1
1993-1996
1991
Streptomyces fradiae (D2SNF5)
-
Manually annotated by BRENDA team
Hammerschmidt, F.; Kählig, H.
Biosynthesis of natural products with a P-C Bond. 7. Synthesis of [1,1-2H2]-, [2,2-2H2]-, (R)- and (S)-[2 H1](2-hydroxyethyl)phosphonic acid and (R,S)-[1-2H1](1,2-dihydroxyethyl)phosphonic acid and incorporation studies into fosfomycin in Streptomyces fradiae
J. Org. Chem.
56
2364-2370
1991
Streptomyces fradiae (D2SNF5)
-
Manually annotated by BRENDA team
Hidaka, T.; Goda, M.; Kuzuyama, T.; Takei, N.; Hidaka, M.; Seto, H.
Cloning and nucleotide sequence of fosfomycin biosynthetic genes of Streptomyces wedmorensis
Mol. Gen. Genet.
249
274-280
1995
Streptomyces wedmorensis (Q56184), Streptomyces wedmorensis 144-91 (Q56184)
Manually annotated by BRENDA team
Seto, H.; Kuzuyama, T.
Bioactive natural products with carbon-phosphorus bonds and their biosynthesis
Nat. Prod. Rep.
16
589-596
1999
Streptomyces fradiae (D2SNF5), Streptomyces wedmorensis (Q56184)
Manually annotated by BRENDA team
Allen, K.D.; Wang, S.C.
Initial characterization of Fom3 from Streptomyces wedmorensis: The methyltransferase in fosfomycin biosynthesis
Arch. Biochem. Biophys.
543
67-73
2014
Streptomyces wedmorensis (Q56184)
Manually annotated by BRENDA team