Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.1.1.319: type I protein arginine methyltransferase

This is an abbreviated version!
For detailed information about type I protein arginine methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.319

Reaction

2 S-adenosyl-L-methionine +

[protein]-L-arginine
= 2 S-adenosyl-L-homocysteine +
[protein]-Nomega,Nomega-dimethyl-L-arginine

Synonyms

arginine methyltransferase 1, CARM1, coactivator-associated arginine methyltransferase 1, coactivator-associated arginine methyltransferase 1 variant 5, EC 2.1.1.124, EC 2.1.1.125, EC 2.1.1.126, EC 2.1.1.23, Eucgr.C03665.1, PRMT I, PRMT-1, PRMT1, PRMT10, PRMT2, PRMT3, PRMT4, PRMT6, PRMT8, protein arginine methyltransferase 1, protein arginine methyltransferase 2, protein arginine methyltransferase 4, protein arginine methyltransferase 6, protein arginine methyltransferase I, protein arginine N-methyltransferase 2, protein arginine N-methyltransferase I, RMT1, Tb927.1.4690, Tb927.5.3960, type I protein arginine methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.319 type I protein arginine methyltransferase

Expression

Expression on EC 2.1.1.319 - type I protein arginine methyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression levels is highly increased after induction of encystation from 24-72 h
expression of PRMT1 mRNA and protein content are significantly induced in skeletal muscle cells during the phenotypic remodeling elicited by myogenesis
following 72 h and 168 h of denervation, PRMT1 protein content increases 3.6-5fold
H2O2 treatment increases isoforms PRMT1 and PRMT4 expression but decreases sirtuin SIRT1 expression. Similar to H2O2 treatment, PRMT1 or PRMT4 overexpression increases retinal pigment epithelial cell damage
PRMT1 mRNA content in the denervated soleus muscle decreases by 32% and 37% as compared with the control muscle after 6 and 12 h, respectively
PRMT4 mRNA content increases 2.3fold or 1.7fold in the denervated muscle compared with the control muscle after 72 and 168 h of denervation, respectively
protein arginine N-methyltransferase 1 expression is significantly upregulated in hepatocellular carcinoma cell lines and clinical tissues
relative to the control muscle, PRMT4 mRNA expression levels in the denervated soleus muscle is decreased by 31% after 12 h
the enzyme is up-regulated and promotes migration, invasion and proliferation in wide range of cancers
the GATA transcription factor elt-2 is a positive regulator of Pprmt-1:: gfp expression. elt-2 RNAi decreases endogenous PRMT-1 expression at mRNA and protein levels
two splice variants of PRMT1 (variants v.1 and v.2) are downregulated in breast cancer