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2.1.1.319: type I protein arginine methyltransferase

This is an abbreviated version!
For detailed information about type I protein arginine methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.319

Reaction

2 S-adenosyl-L-methionine +

[protein]-L-arginine
= 2 S-adenosyl-L-homocysteine +
[protein]-Nomega,Nomega-dimethyl-L-arginine

Synonyms

arginine methyltransferase 1, CARM1, coactivator-associated arginine methyltransferase 1, coactivator-associated arginine methyltransferase 1 variant 5, EC 2.1.1.124, EC 2.1.1.125, EC 2.1.1.126, EC 2.1.1.23, Eucgr.C03665.1, PRMT I, PRMT-1, PRMT1, PRMT10, PRMT2, PRMT3, PRMT4, PRMT6, PRMT8, protein arginine methyltransferase 1, protein arginine methyltransferase 2, protein arginine methyltransferase 4, protein arginine methyltransferase 6, protein arginine methyltransferase I, protein arginine N-methyltransferase 2, protein arginine N-methyltransferase I, RMT1, Tb927.1.4690, Tb927.5.3960, type I protein arginine methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.319 type I protein arginine methyltransferase

Reference

Reference on EC 2.1.1.319 - type I protein arginine methyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hernando, C.E.; Sanchez, S.E.; Mancini, E.; Yanovsky, M.J.
Genome wide comparative analysis of the effects of PRMT5 and PRMT4/CARM1 arginine methyltransferases on the Arabidopsis thaliana transcriptome
BMC Genomics
16
192
2015
Arabidopsis thaliana (Q9MAT5)
Manually annotated by BRENDA team
Fisk, J.C.; Zurita-Lopez, C.; Sayegh, J.; Tomasello, D.L.; Clarke, S.G.; Read, L.K.
TbPRMT6 is a type I protein arginine methyltransferase that contributes to cytokinesis in Trypanosoma brucei
Eukaryot. Cell
9
866-877
2010
Trypanosoma brucei brucei (Q57U70), Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 (Q57U70)
Manually annotated by BRENDA team
Tsai, Y.J.; Pan, H.; Hung, C.M.; Hou, P.T.; Li, Y.C.; Lee, Y.J.; Shen, Y.T.; Wu, T.T.; Li, C.
The predominant protein arginine methyltransferase PRMT1 is critical for zebrafish convergence and extension during gastrulation
FEBS J.
278
905-917
2011
Danio rerio (Q803D9), Danio rerio
Manually annotated by BRENDA team
Tang, J.; Gary, J.D.; Clarke, S.; Herschman, H.R.
PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation
J. Biol. Chem.
273
16935-16945
1998
Rattus norvegicus (O70467)
Manually annotated by BRENDA team
Tang, J.; Kao, P.N.; Herschman, H.R.
Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3
J. Biol. Chem.
275
19866-19876
2000
Homo sapiens (Q99873)
Manually annotated by BRENDA team
Tang, J.; Frankel, A.; Cook, R.J.; Kim, S.; Paik, W.K.; Williams, K.R.; Clarke, S.; Herschman, H.R.
PRMT1 is the predominant type I protein arginine methyltransferase in mammalian cells
J. Biol. Chem.
275
7723-7730
2000
Rattus norvegicus (Q63009)
Manually annotated by BRENDA team
Frankel, A.; Yadav, N.; Lee, J.; Branscombe, T.L.; Clarke, S.; Bedford, M.T.
The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity
J. Biol. Chem.
277
3537-3543
2002
Homo sapiens (Q96LA8), Homo sapiens
Manually annotated by BRENDA team
Lee, J.; Sayegh, J.; Daniel, J.; Clarke, S.; Bedford, M.T.
PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family
J. Biol. Chem.
280
32890-32896
2005
Homo sapiens (Q9NR22), Homo sapiens
Manually annotated by BRENDA team
Koelbel, K.; Ihling, C.; Bellmann-Sickert, K.; Neundorf, I.; Beck-Sickinger, A.G.; Sinz, A.; Kuehn, U.; Wahle, E.
Type I arginine methyltransferases PRMT1 and PRMT-3 act distributively
J. Biol. Chem.
284
8274-8282
2009
Homo sapiens (Q99873)
Manually annotated by BRENDA team
Gupta, N.; Madapura, M.P.; Bhat, U.A.; Rao, M.R.
Mapping of post-translational modifications of transition proteins, TP1 and TP2, and identification of protein arginine methyltransferase 4 and lysine methyltransferase 7 as methyltransferase for TP2
J. Biol. Chem.
290
12101-12122
2015
Rattus norvegicus (A0A068FP44)
Manually annotated by BRENDA team
Pelletier, M.; Pasternack, D.A.; Read, L.K.
In vitro and in vivo analysis of the major type I protein arginine methyltransferase from Trypanosoma brucei
Mol. Biochem. Parasitol.
144
206-217
2005
Trypanosoma brucei brucei (Q4GYA9), Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 (Q4GYA9)
Manually annotated by BRENDA team
Cha, B.; Park, Y.; Hwang, B.N.; Kim, S.Y.; Jho, E.H.
Protein arginine methyltransferase 1 methylates Smurf2
Mol. Cells
38
723-728
2015
Mus musculus
Manually annotated by BRENDA team
Kim, D.I.; Park, M.J.; Choi, J.H.; Kim, I.S.; Han, H.J.; Yoon, K.C.; Park, S.W.; Lee, M.Y.; Oh, K.S.; Park, S.H.
PRMT1 and PRMT4 regulate oxidative stress-induced retinal pigment epithelial cell damage in SIRT1-dependent and SIRT1-independent manners
Oxid. Med. Cell. Longev.
2015
617919
2015
Homo sapiens (Q86X55), Homo sapiens (Q99873), Homo sapiens
Manually annotated by BRENDA team
Pahlich, S.; Bschir, K.; Chiavi, C.; Belyanskaya, L.; Gehring, H.
Different methylation characteristics of protein arginine methyltransferase 1 and 3 toward the Ewing Sarcoma protein and a peptide
Proteins
61
164-175
2005
Homo sapiens (O60678), Homo sapiens (Q99873)
Manually annotated by BRENDA team
Eram, M.S.; Shen, Y.; Szewczyk, M.; Wu, H.; Senisterra, G.; Li, F.; Butler, K.V.; Kaniskan, H.U.e.; Speed, B.A.; Dela Sena, C.; Dong, A.; Zeng, H.; Schapira, M.; Brown, P.J.; Arrowsmith, C.H.; Barsyte-Lovejoy, D.; Liu, J.; Vedadi, M.; Jin, J.
A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases
ACS Chem. Biol.
11
772-781
2016
Homo sapiens (O60678), Homo sapiens (Q86X55), Homo sapiens (Q96LA8), Homo sapiens (Q99873), Homo sapiens (Q9NR22), Homo sapiens
Manually annotated by BRENDA team
Stouth, D.W.; Manta, A.; Ljubicic, V.
Protein arginine methyltransferase expression, localization, and activity during disuse-induced skeletal muscle plasticity
Am. J. Physiol. Cell Physiol.
314
C177-C190
2018
Mus musculus (Q9JIF0), Mus musculus (Q9WVG6)
Manually annotated by BRENDA team
Gunnell, E.A.; Al-Noori, A.; Muhsen, U.; Davies, C.C.; Dowden, J.; Dreveny, I.
Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4)
Biochem. J.
477
787-800
2020
Homo sapiens (Q86X55), Homo sapiens (Q99873)
Manually annotated by BRENDA team
Ye, F.; Zhang, W.; Lu, W.; Xie, Y.; Jiang, H.; Jin, J.; Luo, C.
Identification of novel inhibitors against coactivator associated arginine methyltransferase 1 based on virtual screening and biological assays
BioMed Res. Int.
2016
7086390
2016
Homo sapiens (Q86X55)
Manually annotated by BRENDA team
Gathiaka, S.; Boykin, B.; Caceres, T.; Hevel, J.M.; Acevedo, O.
Understanding protein arginine methyltransferase 1 (PRMT1) product specificity from molecular dynamics
Bioorg. Med. Chem.
24
4949-4960
2016
Rattus norvegicus (Q63009)
Manually annotated by BRENDA team
Yu, X.R.; Tang, Y.; Wang, W.J.; Ji, S.; Ma, S.; Zhong, L.; Zhang, C.H.; Yang, J.; Wu, X.A.; Fu, Z.Y.; Li, L.L.; Yang, S.Y.
Discovery and structure-activity analysis of 4-((5-nitropyrimidin-4-yl)amino)benzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors
Bioorg. Med. Chem. Lett.
25
5449-5453
2015
Homo sapiens (Q99873)
Manually annotated by BRENDA team
Shen, N.Y.; Ng, S.Y.; Toepp, S.L.; Ljubicic, V.
Protein arginine methyltransferase expression and activity during myogenesis
Biosci. Rep.
38
BSR20171533
2018
Mus musculus (Q9JIF0)
Manually annotated by BRENDA team
Yu, C.H.; Chou, C.C.; Lee, D.Y.; Khoo, K.H.; Chang, G.D.
Target identification reveals protein arginine methyltransferase 1 is a potential target of phenyl vinyl sulfone and its derivatives
Biosci. Rep.
38
BSR20171717
2018
Homo sapiens
Manually annotated by BRENDA team
Plett, K.; Raposo, A.; Bullivant, S.; Anderson, I.; Piller, S.; Plett, J.
Root morphogenic pathways in Eucalyptus grandis are modified by the activity of protein arginine methyltransferases
BMC Plant Biol.
17
62
2017
Eucalyptus grandis
Manually annotated by BRENDA team
Zhang, H.; Han, C.; Li, T.; Li, N.; Cao, X.
The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1-IRF3 signaling
Cell. Mol. Immunol.
16
800-809
2019
Mus musculus (Q6NZB1)
Manually annotated by BRENDA team
Qiao, X.; Kim, D.I.; Jun, H.; Ma, Y.; Knights, A.J.; Park, M.J.; Zhu, K.; Lipinski, J.H.; Liao, J.; Li, Y.; Richard, S.; Weinman, S.A.; Wu, J.
Protein arginine methyltransferase 1 interacts with PGC1alpha and modulates thermogenic fat activation
Endocrinology
160
2773-2786
2019
Homo sapiens (Q99873), Homo sapiens, Mus musculus (Q9JIF0), Mus musculus
Manually annotated by BRENDA team
Zhang, Y.; Wang, D.; Zhang, M.; Wei, H.; Lu, Y.; Sun, Y.; Zhou, M.; Gu, S.; Feng, W.; Wang, H.; Zeng, J.; Gong, A.; Xu, M.
Protein arginine methyltransferase 1 coordinates the epithelial-mesenchymal transition/proliferation dichotomy in gastric cancer cells
Exp. Cell Res.
362
43-50
2018
Homo sapiens (Q99873)
Manually annotated by BRENDA team
Cura, V.; Marechal, N.; Troffer-Charlier, N.; Strub, J.M.; van Haren, M.J.; Martin, N.I.; Cianferani, S.; Bonnefond, L.; Cavarelli, J.
Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors
FEBS J.
284
77-96
2017
Danio rerio (A1L1Q4), Mus musculus (Q9R144)
Manually annotated by BRENDA team
Berberich, H.; Terwesten, F.; Rakow, S.; Sahu, P.; Bouchard, C.; Meixner, M.; Philipsen, S.; Kolb, P.; Bauer, U.M.
Identification and insilico structural analysis of Gallus gallus protein arginine methyltransferase 4 (PRMT4)
FEBS open bio
7
1909-1923
2017
Gallus gallus (A0A2D3I4C6)
Manually annotated by BRENDA team
Adamopoulos, P.G.; Mavrogiannis, A.V.; Kontos, C.K.; Scorilas, A.
Novel alternative splice variants of the human protein arginine methyltransferase 1 (PRMT1) gene, discovered using next-generation sequencing
Gene
699
135-144
2019
Homo sapiens (Q99873), Homo sapiens
Manually annotated by BRENDA team
Hu, S.B.; Xiang, J.F.; Li, X.; Xu, Y.; Xue, W.; Huang, M.; Wong, C.C.; Sagum, C.A.; Bedford, M.T.; Yang, L.; Cheng, D.; Chen, L.L.
Protein arginine methyltransferase CARM1 attenuates the paraspeckle-mediated nuclear retention of mRNAs containing IRAlus
Genes Dev.
29
630-645
2015
Mus musculus (Q9WVG6)
Manually annotated by BRENDA team
Sun, Y.; Wang, Z.; Yang, H.; Zhu, X.; Wu, H.; Ma, L.; Xu, F.; Hong, W.; Wang, H.
The Development of tetrazole derivatives as protein arginine methyltransferase I (PRMT I) inhibitors
Int. J. Mol. Sci.
20
3840
2019
Homo sapiens (Q99873)
Manually annotated by BRENDA team
Araoi, S.; Daitoku, H.; Yokoyama, A.; Kako, K.; Hirota, K.; Fukamizu, A.
The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans
J. Biochem.
163
433-440
2018
Caenorhabditis elegans (Q9U2X0), Caenorhabditis elegans
Manually annotated by BRENDA team
Patounas, O.; Papacharalampous, I.; Eckerich, C.; Markopoulos, G.S.; Kolettas, E.; Fackelmayer, F.O.
A novel splicing isoform of protein arginine methyltransferase 1 (PRMT1) that lacks the dimerization arm and correlates with cellular malignancy
J. Cell. Biochem.
119
2110-2123
2018
Homo sapiens (Q99873), Homo sapiens
Manually annotated by BRENDA team
Li, M.; An, W.; Xu, L.; Lin, Y.; Su, L.; Liu, X.
The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells
J. Exp. Clin. Cancer Res.
38
64
2019
Homo sapiens (Q99873), Homo sapiens
Manually annotated by BRENDA team
Bonnefond, L.; Stojko, J.; Mailliot, J.; Troffer-Charlier, N.; Cura, V.; Wurtz, J.M.; Cianferani, S.; Cavarelli, J.
Functional insights from high resolution structures of mouse protein arginine methyltransferase 6
J. Struct. Biol.
191
175-183
2015
Mus musculus (Q6NZB1), Mus musculus
Manually annotated by BRENDA team
Moon, E.K.; Kong, H.H.; Hong, Y.; Lee, H.A.; Quan, F.S.
Identification and Characterization of Protein Arginine Methyltransferase 1 in Acanthamoeba castellanii
Korean J. Parasitol.
55
109-114
2017
Acanthamoeba castellanii (A0A0U3T8U3), Acanthamoeba castellanii
Manually annotated by BRENDA team
Kaniskan, H.U.e.; Eram, M.S.; Liu, J.; Smil, D.; Martini, M.L.; Shen, Y.; Santhakumar, V.; Brown, P.J.; Arrowsmith, C.; Vedadi, M.; Jin, J.
Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1)
MedChemComm
7
1793-1796
2016
Homo sapiens (Q86X55), Homo sapiens
Manually annotated by BRENDA team
Yakubu, R.R.; Silmon de Monerri, N.C.; Nieves, E.; Kim, K.; Weiss, L.M.
Comparative monomethylarginine proteomics suggests that protein arginine methyltransferase 1 (PRMT1) is a significant contributor to arginine monomethylation in Toxoplasma gondii
Mol. Cell. Proteomics
16
567-580
2017
Toxoplasma gondii
Manually annotated by BRENDA team
Bao, J.; Rousseaux, S.; Shen, J.; Lin, K.; Lu, Y.; Bedford, M.T.
The arginine methyltransferase CARM1 represses p300/ACT/CREMtau activity and is required for spermiogenesis
Nucleic Acids Res.
46
4327-4343
2018
Mus musculus (Q9WVG6), Mus musculus
Manually annotated by BRENDA team
Shen, Y.; Zhong, J.; Liu, J.; Liu, K.; Zhao, J.; Xu, T.; Zeng, T.; Li, Z.; Chen, Y.; Ding, W.; Wen, G.; Zu, X.; Cao, R.
Protein arginine N-methyltransferase2 reverses tamoxifen resistance in breast cancer cells through suppression of ER-alpha36
Oncol. Rep.
39
2604-2612
2018
Homo sapiens (P55345), Homo sapiens
Manually annotated by BRENDA team
Fan, Z.; Li, J.; Li, P.; Ye, Q.; Xu, H.; Wu, X.; Xu, Y.
Protein arginine methyltransferase 1 (PRMT1) represses MHC II transcription in macrophages by methylating CIITA
Sci. Rep.
7
40531
2017
Mus musculus (Q9JIF0)
Manually annotated by BRENDA team
Favia, A.; Salvatori, L.; Nanni, S.; Iwamoto-Stohl, L.; Valente, S.; Mai, A.; Scagnoli, F.; Fontanella, R.; Totta, P.; Nasi, S.; Illi, B.
The protein arginine methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells
Sci. Rep.
9
15925
2019
Homo sapiens (Q99873)
Manually annotated by BRENDA team
Gou, Q.; He, S.; Zhou, Z.
Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells
Tumour Biol.
39
1010428317691419
2017
Homo sapiens (Q99873)
Manually annotated by BRENDA team