2.1.1.320: type II protein arginine methyltransferase
This is an abbreviated version!
For detailed information about type II protein arginine methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.320
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2.1.1.320
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histone
-
methyltransferases
-
chromatin
-
prmts
-
dimethylarginine
-
tumorigenesis
-
h4r3me2s
-
monomethylation
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spliceosomal
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mep50
-
methylosome
-
ribonucleoproteins
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non-histone
-
pre-mrna
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snrnps
-
picln
-
monomethylarginine
-
methylthioadenosine
-
tudor
-
menin
-
protein-arginine
-
medicine
- 2.1.1.320
- histone
- methyltransferases
- chromatin
-
prmts
- dimethylarginine
- tumorigenesis
-
h4r3me2s
-
monomethylation
-
spliceosomal
- mep50
-
methylosome
- ribonucleoproteins
-
non-histone
- pre-mrna
-
snrnps
-
picln
-
monomethylarginine
- methylthioadenosine
-
tudor
-
menin
- protein-arginine
- medicine
Reaction
2 S-adenosyl-L-methionine
+
Synonyms
At4g31120, EC 2.1.1.124, EC 2.1.1.125, EC 2.1.1.126, EC 2.1.1.23, Hsl7, Jak-binding protein 1, Janus kinase-binding protein 1, JBP1, PRMT-5, PRMT-9, PRMT15, PRMT5, PRMT7, PRMT9, protein arginine methyltransferase 5, Skb1
ECTree
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Reference on EC 2.1.1.320 - type II protein arginine methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rho, J.; Choi, S.; Seong, Y.R.; Cho, W.K.; Kim, S.H.; Im, D.S.
PRMT5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family
J. Biol. Chem.
276
11393-11401
2001
Homo sapiens (O14744), Homo sapiens
Branscombe, T.L.; Frankel, A.; Lee, J.H.; Cook, J.R.; Yang, Z.; Pestka, S.; Clarke, S.
PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins
J. Biol. Chem.
276
32971-32976
2001
Homo sapiens
Sayegh, J.; Clarke, S.G.
Hsl7 is a substrate-specific type II protein arginine methyltransferase in yeast
Biochem. Biophys. Res. Commun.
372
811-815
2008
Saccharomyces cerevisiae (P38274), Saccharomyces cerevisiae
Lacroix, M.; Messaoudi, S.E.; Rodier, G.; Le Cam, A.; Sardet, C.; Fabbrizio, E.
The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5
EMBO Rep.
9
452-458
2008
Homo sapiens (O14744)
Wilczek, C.; Chitta, R.; Woo, E.; Shabanowitz, J.; Chait, B.T.; Hunt, D.F.; Shechter, D.
Protein arginine methyltransferase Prmt5-Mep50 methylates histones H2A and H4 and the histone chaperone nucleoplasmin in Xenopus laevis eggs
J. Biol. Chem.
286
42221-42231
2011
Xenopus laevis (Q6NUA1), Xenopus laevis
Sakai, N.; Saito, Y.; Fujiwara, Y.; Shiraki, T.; Imanishi, Y.; Koshimizu, T.A.; Shibata, K.
Identification of protein arginine N-methyltransferase 5 (PRMT5) as a novel interacting protein with the tumor suppressor protein RASSF1A
Biochem. Biophys. Res. Commun.
467
778-784
2015
Homo sapiens (O14744)
Sohail, M.; Zhang, M.; Litchfield, D.; Wang, L.; Kung, S.; Xie, J.
Differential expression, distinct localization and opposite effect on Golgi structure and cell differentiation by a novel splice variant of human PRMT5
Biochim. Biophys. Acta
1853
2444-2452
2015
Homo sapiens (O14744), Homo sapiens
Wang, Y.; Li, Q.; Liu, C.; Han, F.; Chen, M.; Zhang, L.; Cui, X.; Qin, Y.; Bao, S.; Gao, F.
Protein arginine methyltransferase 5 (Prmt5) is required for germ cell survival during mouse embryonic development
Biol. Reprod.
92
104
2015
Mus musculus
Hernando, C.E.; Sanchez, S.E.; Mancini, E.; Yanovsky, M.J.
Genome wide comparative analysis of the effects of PRMT5 and PRMT4/CARM1 arginine methyltransferases on the Arabidopsis thaliana transcriptome
BMC Genomics
16
192
2015
Arabidopsis thaliana (Q8GWT4), Arabidopsis thaliana
Zhou, Z.; Sun, X.; Zou, Z.; Sun, L.; Zhang, T.; Guo, S.; Wen, Y.; Liu, L.; Wang, Y.; Qin, J.; Li, L.; Gong, W.; Bao, S.
PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130
Cell Res.
20
1023-1033
2010
Homo sapiens (O14744)
Shilo, K.; Wu, X.; Sharma, S.; Welliver, M.; Duan, W.; Villalona-Calero, M.; Fukuoka, J.; Sif, S.; Baiocchi, R.; Hitchcock, C.L.; Zhao, W.; Otterson, G.A.
Cellular localization of protein arginine methyltransferase-5 correlates with grade of lung tumors
Diagn. Pathol.
8
201
2013
Homo sapiens (O14744)
Huang, J.; Vogel, G.; Yu, Z.; Almazan, G.; Richard, S.
Type II arginine methyltransferase PRMT5 regulates gene expression of inhibitors of differentiation/DNA binding Id2 and Id4 during glial cell differentiation
J. Biol. Chem.
286
44424-44432
2011
Mus musculus, Rattus norvegicus (D4A0E8)
Hadjikyriacou, A.; Yang, Y.; Espejo, A.; Bedford, M.T.; Clarke, S.G.
Unique features of human protein arginine methyltransferase 9 (PRMT9) and its substrate RNA splicing Factor SF3B2
J. Biol. Chem.
290
16723-16743
2015
Homo sapiens (Q6P2P2), Homo sapiens
Gonsalvez, G.B.; Tian, L.; Ospina, J.K.; Boisvert, F.M.; Lamond, A.I.; Matera, A.G.
Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins
J. Cell Biol.
178
733-740
2007
Homo sapiens (O14744), Homo sapiens
Liu, F.; Cheng, G.; Hamard, P.J.; Greenblatt, S.; Wang, L.; Man, N.; Perna, F.; Xu, H.; Tadi, M.; Luciani, L.; Nimer, S.D.
Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis
J. Clin. Invest.
125
3532-3544
2015
Mus musculus (Q8CIG8)
Zhang, W.; Zhang, Y.; Zhao, X.; Hua, Y.; Wu, Z.; Yan, Y.; Li, Y.
Prmt7 regulates epiboly by facilitating 2-OST and modulating actin cytoskeleton
J. Mol. Cell Biol.
7
489-491
2015
Danio rerio (A2AV36)
Quan, X.; Yue, W.; Luo, Y.; Cao, J.; Wang, H.; Wang, Y.; Lu, Z.
The protein arginine methyltransferase PRMT5 regulates Abeta-induced toxicity in human cells and Caenorhabditis elegans models of Alzheimers disease
J. Neurochem.
134
969-977
2015
Caenorhabditis elegans (P46580), Caenorhabditis elegans, Homo sapiens (O14744), Homo sapiens
Zhang, T.; Guenther, S.; Looso, M.; Kuenne, C.; Krueger, M.; Kim, J.; Zhou, Y.; Braun, T.
Prmt5 is a regulator of muscle stem cell expansion in adult mice
Nat. Commun.
6
7140
2015
Mus musculus (Q8CIG8), Mus musculus
Gu, Z.; Li, Y.; Lee, P.; Liu, T.; Wan, C.; Wang, Z.
Protein arginine methyltransferase 5 functions in opposite ways in the cytoplasm and nucleus of prostate cancer cells
PLoS ONE
7
e44033
2012
Homo sapiens (O14744)
Ho, M.C.; Wilczek, C.; Bonanno, J.B.; Xing, L.; Seznec, J.; Matsui, T.; Carter, L.G.; Onikubo, T.; Kumar, P.R.; Chan, M.K.; Brenowitz, M.; Cheng, R.H.; Reimer, U.; Almo, S.C.; Shechter, D.
Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity
PLoS ONE
8
e57008
2013
Xenopus laevis (Q6NUA1), Xenopus laevis
Hong, S.; Song, H.R.; Lutz, K.; Kerstetter, R.A.; Michael, T.P.; McClung, C.R.
Type II protein arginine methyltransferase 5 (PRMT5) is required for circadian period determination in Arabidopsis thaliana
Proc. Natl. Acad. Sci. USA
107
21211-21216
2010
Arabidopsis thaliana (Q8GWT4), Arabidopsis thaliana
Antonysamy, S.; Bonday, Z.; Campbell, R.M.; Doyle, B.; Druzina, Z.; Gheyi, T.; Han, B.; Jungheim, L.N.; Qian, Y.; Rauch, C.; Russell, M.; Sauder, J.M.; Wasserman, S.R.; Weichert, K.; Willard, F.S.; Zhang, A.; Emtage, S.
Crystal structure of the human PRMT5:MEP50 complex
Proc. Natl. Acad. Sci. USA
109
17960-17965
2012
Homo sapiens (O14744), Homo sapiens
Likhite, N.; Jackson, C.A.; Liang, M.S.; Krzyzanowski, M.C.; Lei, P.; Wood, J.F.; Birkaya, B.; Michaels, K.L.; Andreadis, S.T.; Clark, S.D.; Yu, M.C.; Ferkey, D.M.
The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling
Sci. Signal.
8
ra115
2015
Homo sapiens (O14744), Homo sapiens, Caenorhabditis elegans (P46580), Caenorhabditis elegans
Stouth, D.W.; Manta, A.; Ljubicic, V.
Protein arginine methyltransferase expression, localization, and activity during disuse-induced skeletal muscle plasticity
Am. J. Physiol. Cell Physiol.
314
C177-C190
2018
Mus musculus (Q8CIG8)
Hadjikyriacou, A.; Clarke, S.G.
Caenorhabditis elegans PRMT-7 and PRMT-9 are evolutionarily conserved protein arginine methyltransferases with distinct substrate specificities
Biochemistry
56
2612-2626
2017
Caenorhabditis elegans (O02325), Caenorhabditis elegans
Fan, Z.; Kong, X.; Xia, J.; Wu, X.; Li, H.; Xu, H.; Fang, M.; Xu, Y.
The arginine methyltransferase PRMT5 regulates CIITA-dependent MHC II transcription
Biochim. Biophys. Acta
1859
687-696
2016
Homo sapiens (O14744), Mus musculus (Q8CIG8)
di Caprio, R.; Ciano, M.; Montano, G.; Costanzo, P.; Cesaro, E.
KAP1 is a novel substrate for the arginine methyltransferase PRMT5
Biology
4
41-49
2015
Homo sapiens (O14744)
Zhu, K.; Song, J.L.; Tao, H.R.; Cheng, Z.Q.; Jiang, C.S.; Zhang, H.
Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors
Bioorg. Med. Chem. Lett.
28
3693-3699
2018
Homo sapiens (O14744), Homo sapiens
Lin, H.; Luengo, J.I.
Nucleoside protein arginine methyltransferase 5 (PRMT5) inhibitors
Bioorg. Med. Chem. Lett.
29
1264-1269
2019
Homo sapiens (O14744)
Sheng, X.; Wang, Z.
Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation
BMC Cancer
16
567
2016
Homo sapiens (O14744)
Stopa, N.; Krebs, J.E.; Shechter, D.
The PRMT5 arginine methyltransferase many roles in development, cancer and beyond
Cell. Mol. Life Sci.
72
2041-2059
2015
Homo sapiens (O14744), Homo sapiens, Caenorhabditis elegans (P46580), Caenorhabditis elegans, Xenopus laevis (Q6NUA1)
Zhu, J.; Zhang, D.; Liu, X.; Yu, G.; Cai, X.; Xu, C.; Rong, F.; Ouyang, G.; Wang, J.; Xiao, W.
Zebrafish prmt5 arginine methyltransferase is essential for germ cell development
Development
146
dev179572
2019
Danio rerio (B0R026), Danio rerio
Bowitch, A.; Michaels, K.; Yu, M.; Ferkey, D.
The protein arginine methyltransferase PRMT-5 regulates SER-2 tyramine receptor-mediated behaviors in Caenorhabditis elegans
G3 (Bethesda)
8
2389-2398
2018
Caenorhabditis elegans (P46580), Caenorhabditis elegans
Chung, J.; Karkhanis, V.; Baiocchi, R.A.; Sif, S.
Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/?-catenin and AKT/GSK3? proliferative signaling
J. Biol. Chem.
294
7692-7710
2019
Homo sapiens (O14744), Mus musculus (Q8CIG8), Mus musculus
Li, M.; An, W.; Xu, L.; Lin, Y.; Su, L.; Liu, X.
The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells
J. Exp. Clin. Cancer Res.
38
64
2019
Homo sapiens (O14744), Homo sapiens
Wang, Y.; Hu, W.; Yuan, Y.
Protein arginine methyltransferase 5 (PRMT5) as an anticancer target and its inhibitor discovery
J. Med. Chem.
61
9429-9441
2018
Homo sapiens (O14744)
Chatterjee, B.; Ghosh, K.; Suresh, L.; Kanade, S.
Curcumin ameliorates PRMT5-MEP50 arginine methyltransferase expression by decreasing the Sp1 and NF-YA transcription factors in the A549 and MCF-7 cells
Mol. Cell. Biochem.
455
73-90
2019
Homo sapiens (O14744), Homo sapiens
Liu, M.; Li, F.; Li, C.; Li, X.; Chen, L.; Wu, K.; Yang, P.; Lai, Z.; Liu, T.; Sullivan, W.J.; Cui, L.; Chen, X.
Characterization of protein arginine methyltransferase of TgPRMT5 in Toxoplasma gondii
Parasit. Vectors
12
221
2019
Toxoplasma gondii (S7UQT1), Toxoplasma gondii, Toxoplasma gondii ATCC 50853 (S7UQT1)
Jain, K.; Jin, C.; Clarke, S.
Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases
Proc. Natl. Acad. Sci. USA
114
10101-10106
2017
Homo sapiens (O14744)
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