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2.1.1.320: type II protein arginine methyltransferase

This is an abbreviated version!
For detailed information about type II protein arginine methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.320

Reaction

2 S-adenosyl-L-methionine +

[protein]-L-arginine
= 2 S-adenosyl-L-homocysteine +
[protein]-Nomega,Nomega'-dimethyl-L-arginine

Synonyms

At4g31120, EC 2.1.1.124, EC 2.1.1.125, EC 2.1.1.126, EC 2.1.1.23, Hsl7, Jak-binding protein 1, Janus kinase-binding protein 1, JBP1, PRMT-5, PRMT-9, PRMT15, PRMT5, PRMT7, PRMT9, protein arginine methyltransferase 5, Skb1

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.320 type II protein arginine methyltransferase

Source Tissue

Source Tissue on EC 2.1.1.320 - type II protein arginine methyltransferase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
PRMT5 expression gradually increases throughout postnatal brain development, coinciding with the period of active myelination
Manually annotated by BRENDA team
histone H2A and nucleoplasmin methylation appears late in oogenesis and is most abundant in the laid egg
Manually annotated by BRENDA team
-
isoform PRMT5 is abundantly expressed in the germ cells of both male and female gonads
Manually annotated by BRENDA team
lung carcinoma
Manually annotated by BRENDA team
skeletal muscle stem cell
Manually annotated by BRENDA team
PRMT5 enzyme localization is concentrated in the cytosolic, membrane, and myonuclear compartments of mature myofibers
Manually annotated by BRENDA team
additional information
Prmt7 transcripts and protein are maternally deposited and ubiquitously expressed through gastrulation
Manually annotated by BRENDA team