2.1.1.321: type III protein arginine methyltransferase
This is an abbreviated version!
For detailed information about type III protein arginine methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.321
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2.1.1.321
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prmt7
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histone
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monomethylation
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metastasis
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monomethylarginine
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dimethylarginine
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nanog
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adomet
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medicine
- 2.1.1.321
- prmt7
- histone
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monomethylation
- metastasis
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monomethylarginine
- dimethylarginine
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nanog
- adomet
- medicine
Reaction
Synonyms
EC 2.1.1.124, EC 2.1.1.125, EC 2.1.1.126, EC 2.1.1.23, PRMT-7, PRMT7, protein arginine methyltransferase 7
ECTree
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Engineering
Engineering on EC 2.1.1.321 - type III protein arginine methyltransferase
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F71A
the mutant preserves the type III (mono)methyltransferase behavior of the native enzyme
F71I
the mutation of Phe71 to Ile converts the enzyme from a type III (mono)methyltransferase into a mixed type I/II, that is, an enzyme that can now perform dimethylation
F71S
the mutant preserves the type III (mono)methyltransferase behavior of the native enzyme
F71A
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the mutant preserves the type III (mono)methyltransferase behavior of the native enzyme
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F71I
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the mutation of Phe71 to Ile converts the enzyme from a type III (mono)methyltransferase into a mixed type I/II, that is, an enzyme that can now perform dimethylation
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F71S
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the mutant preserves the type III (mono)methyltransferase behavior of the native enzyme
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additional information
truncated proteins consisiting of one of the two putative AdoMet-binding motifs are enzymatically inactive
additional information
mutation of motif I residues LDIG to AAAA creates a catalytically inactive enzyme that cannot bind AdoMet
additional information
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mutation of motif I residues LDIG to AAAA creates a catalytically inactive enzyme that cannot bind AdoMet