2.1.1.326: N-acetyldemethylphosphinothricin P-methyltransferase

This is an abbreviated version!
For detailed information about N-acetyldemethylphosphinothricin P-methyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

Synonyms

BcpD, P-methylase, PhpK, SD_1168

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.326 N-acetyldemethylphosphinothricin P-methyltransferase

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Results	in table
1	AA Sequence
3	Cloned(Commentary)
4	Cofactor
3	General Information
2	Metals/Ions
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
10	Organism
4	Pathway
1	Purification (Commentary)
1	Reaction
9	Reference
14	Substrates and Products (Substrate)
2	Subunits
8	Synonyms
1	Systematic Name

Metals Ions

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Metals Ions on EC 2.1.1.326 - N-acetyldemethylphosphinothricin P-methyltransferase

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[4Fe-4S] center

Kitasatospora phosalacinea

A0A059U454

the enzyme is a radical S-adenosyl-L-methionine enzyme that contains a [4Fe-4S] center and a methylcob(III)alamin cofactor. According to the proposed mechanism, the reduced iron-sulfur center donates an electron to S-adenosyl-L-methionine, resulting in homolytic cleavage of the carbon-sulfur bond to form a 5'-deoxyadenosyl radical that abstracts the hydrogen atom from the P-H bond of the substrate, forming a phosphinate-centered radical. This radical reacts with methylcob(III)alamin to produce the methylated product and cob(II)alamin, which is reduced by an unknown donor to cob(I)alamin. A potential route for restoring the latter back to methylcob(III)alamin is a nucleophilic attack on a second S-adenosyl-L-methionine molecule

735668

[4Fe-4S] cluster

Shewanella denitrificans

the enzyme binds 6.1 mol of iron per mol protein and 4.0 mol of sulfid

737755