2.1.1.34: tRNA (guanosine18-2'-O)-methyltransferase
This is an abbreviated version!
For detailed information about tRNA (guanosine18-2'-O)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.34
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2.1.1.34
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thermophilus
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thermus
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d-loops
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ribose
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methyltransferases
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trnaphe
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adomet
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2'-o-methyltransferases
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2'-o-methylguanosine
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analysis
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s-adenosyl-l-homocysteine
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medicine
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methyl-transfer
- 2.1.1.34
- thermophilus
-
thermus
-
d-loops
- ribose
- methyltransferases
- trnaphe
- adomet
-
2'-o-methyltransferases
- 2'-o-methylguanosine
- analysis
- s-adenosyl-l-homocysteine
- medicine
-
methyl-transfer
Reaction
Synonyms
methyltransferase, transfer ribonucleate guanosine 2'-, S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase, SpoU, TARBP1, transfer ribonucleate guanosine 2'-methyltransferase, transfer RNA (Gm18) methyltransferase, TrmH, tRNA (Gm18) 2'-O-methyltransferase, tRNA (Gm18) methyltransferase, tRNA (guanosine-2'-O-)-methyltransferase, tRNA Gm18 methyltransferase, tRNA guanosine 2'-methyltransferase
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Reaction
Reaction on EC 2.1.1.34 - tRNA (guanosine18-2'-O)-methyltransferase
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S-adenosyl-L-methionine + guanosine18 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
S-adenosyl-L-methionine + guanosine18 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
substrate recognition sites and mechanism
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S-adenosyl-L-methionine + guanosine18 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
G18, G19 and the D-stem of the tRNA are required for Gm-methylase recognition
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S-adenosyl-L-methionine + guanosine18 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
methylation site
Q9FAC4
S-adenosyl-L-methionine + guanosine18 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
mechanism, upon binding of guanine 18, a RNA main chain phosphate group activates R41, which then deprotonates the 2'-OH-group for methylation
Q9FAC4
S-adenosyl-L-methionine + guanosine18 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
substrate recognition sites and mechanism
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
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S-adenosyl-L-methionine + guanosine18 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
G18, G19 and the D-stem of the tRNA are required for Gm-methylase recognition
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
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