2.1.1.37: DNA (cytosine-5-)-methyltransferase

This is an abbreviated version!
For detailed information about DNA (cytosine-5-)-methyltransferase, go to the full flat file.

Reaction

Synonyms

5-cytosine DNA methyltransferase, C5 MTase, C5-MTase, CG recognizing DNA methyltransferase SssI, CMT1, CMT3, cytosine 5-methyltransferase, cytosine carbon 5 DNA methyltransferase, cytosine DNA methylase, cytosine DNA methyltransferase, cytosine DNA MTase, cytosine-5 methyltransferase, cytosine-specific DNA methyltransferase, DCM, DCMT, deoxyribonucleate methylase, deoxyribonucleate methyltransferase, deoxyribonucleic (cytosine-5-)-methyltransferase, deoxyribonucleic acid (cytosine-5-)-methyltransferase, deoxyribonucleic acid methylase, deoxyribonucleic acid methyltransferase, deoxyribonucleic acid modification methylase, deoxyribonucleic methylase, DMT1, DNA (cytosine-5) methyltransferase, DNA (cytosine-5)-methyltransferase 1, DNA (cytosine-5)-methyltransferase 2, DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3B, DNA (cytosine-5-)-methyltransferase 3A, DNA (cytosine-C5) methyltransferase, DNA 5-cytosine methylase, DNA cytosine C(5)-methyltransferase, DNA cytosine c5 methylase, DNA cytosine methylase, DNA cytosine methyltransferase, DNA cytosine-5 methyltransferase 1, DNA cytosine-5-methyltransferase 1, DNA cytosine-5-methyltransferase 3A, DNA cytosine-5-methyltransferase 3B, DNA methylase, DNA methyltransferase, DNA methyltransferase 1, DNA methyltransferase 3a, DNA methyltransferase-1, DNA MTase, DNA transmethylase, DNA-cytosine 5-methylase, DNA-cytosine methyltransferase, DNA-methyltransferase, DNMT, Dnmt1, Dnmt1 DNA-(cytosine-C5)-methyltransferase, DNMT1 methyltransferase, Dnmt1o, Dnmt2, Dnmt3, Dnmt3a, DNMT3B, DNMT3b2, DNMTB, DRM1/2, EC 2.1.1.73, EcoRI methylase, EcoRII DNA-cytosine methylase, EhMeth, hDNMT1, hhaIM, HpaII, M.BssHII, M.BsuRIa, M.BsuRIb, M.EcoHK31l, M.HhaI, M.HhaIII, M.MpeI, M.MspI, M.SsoII, M.Ssp6803I, M.SssI, MarII, MET1, MET1B, methylphosphotriester-DNA methyltransferase, methyltransferase, deoxyribonucleate, More, MspI DNA methyltransferase, MYPE4940, NSUN2, Nt-DRM1, SinI DNA methyltransferase, SsoII, ssoIIM, SSSI, sssIM, ssssIM, type II DNA methylase, Z2389, Zmt3

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.37 DNA (cytosine-5-)-methyltransferase

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Results	in table
10	Activating Compound
54547	AA Sequence
3	Application
1	CAS Registry Number
46	Cloned(Commentary)
34	Cofactor
5	Crystallization (Commentary)
13317	Disease/ Diagnostics
3	Expression
23	General Information
1	General Stability
44	IC50 Value
135	Inhibitors
35	Ki Value [mM]
81	KM Value [mM]
31	Localization
1	Metals/Ions
23	Molecular Weight [Da]
68	Natural Substrates/ Products (Substrates)
167	Organism
4	Pathway
187	PDB ID
13	pH Optimum
2	pH Range
2	Posttranslational Modification
57	Protein Variants
33	Purification (Commentary)
8	Reaction
1	Reaction Type
144	Reference
87	Source Tissue
12	Specific Activity [micromol/min/mg]
13	Storage Stability
246	Substrates and Products (Substrate)
17	Subunits
227	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
7	Temperature Stability [°C]
34	Turnover Number [1/s]

KM Value

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KM Value on EC 2.1.1.37 - DNA (cytosine-5-)-methyltransferase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0008

(CGG*CCG)12

Homo sapiens

P26358

-

485304

-

0.0001

(CGG*CCG)73

Homo sapiens

P26358

-

485304

-

0.0000783

CpNpG

Nicotiana tabacum

-

pH 7.0

659271

0.0000459

CpNpN

Nicotiana tabacum

-

pH 7.0

659271

0.0005 - 0.0016

dGdC

2 entries

0.0004 - 0.0012

dIdC

2 entries

0.00025 - 0.092

DNA

4 entries

0.000037

hemimethylated CpG

Nicotiana tabacum

-

pH 7.0

659271

-

0.02

linear pRW 3602 DNA containing cytosine

Homo sapiens

P26358

-

485304

-

0.086

Micrococcus luteus DNA containing cytosine

Homo sapiens

-

-

485275

-

0.52 - 1.4

mononucleosomal DNA containing cytosine

2 entries

-

0.0077

native Micrococcus lysodeikticus DNA containing cytosine

Homo sapiens

-

-

485286

-

0.015

P815 DNA containing cytosine

Homo sapiens

-

-

485286

-

0.00636

poly(dG-dC)

Nicotiana tabacum

-

pH 7.0

659271

0.0009 - 0.0035

poly(dG-dC)-poly(dG-dC)

4 entries

-

0.00189

poly(dI*dC-dI*dC) of chain length 100

Mus musculus

-

-

485302

-

0.000125

poly(dI*dC-dI*dC) of chain length 2000

Mus musculus

-

-

485302

-

0.0003

poly(dI*dC-dI*dC) of chain length 500

Mus musculus

-

-

485302

-

0.00014

poly(dI*dC-dI*dC) of chain length 5000

Mus musculus

-

-

485302

-

0.00258

poly(dI-dC)

Nicotiana tabacum

-

pH 7.0

659271

0.0005 - 0.0007

poly(dI-dC)*poly(dI-dC)

2 entries

-

0.0003 - 0.0015

poly(dI-dC)-poly(dI-dC)

3 entries

-

0.000973

poly(dIdC:dIdC)

Mus musculus

-

-

485295

-

0.0005 - 0.00082

poly-(dI-dC)/poly(dI-dC)

3 entries

-

0.003

relaxed circular pRW 3602 DNA containing cytosine

Homo sapiens

P26358

-

485304

-

0.00011 - 0.021

S-adenosyl-L-methionine

29 entries

0.023

supercoiled pRW 3602 DNA containing cytosine

Homo sapiens

P26358

-

485304

-

0.0000037 - 0.000004

unmethylated 30-mer DNA containing cytosine

2 entries

-

0.0000273

unmethylated CpG

Nicotiana tabacum

-

pH 7.0

659271

additional information

additional information

12 entries

-

0.0005

dGdC

Mus musculus

O88508, O88509

pH 7.4, 37°C, Dnmt3b

659080

0.0016

dGdC

Mus musculus

O88508, O88509

pH 7.4, 37°C, Dnmt3b

659080

0.0004

dIdC

Mus musculus

O88508, O88509

pH 7.4, 37°C, Dnmt3b

659080

0.0012

dIdC

Mus musculus

O88508, O88509

pH 7.4, 37°C, Dnmt3b

659080

0.00025

DNA

Mus musculus

O88508, O88509

enzyme Dnmt3A, in presence of Dnmt3L

659456

0.00076

DNA

Mus musculus

O88508, O88509

enzyme Dnmt3A, in absence of Dnmt3L

659456

0.041

DNA

Homo sapiens

P26358, Q9Y6K1

-

657772

0.092

DNA

Homo sapiens

P26358, Q9Y6K1

-

657772

0.52

mononucleosomal DNA containing cytosine

Homo sapiens

P26358, Q9Y6K1

-

657772

-

1.4

mononucleosomal DNA containing cytosine

Homo sapiens

P26358, Q9Y6K1

-

657772

-

0.0009

poly(dG-dC)-poly(dG-dC)

Mus musculus

-

isoenzyme Dnmt3b2

485307

-

0.001

poly(dG-dC)-poly(dG-dC)

Mus musculus

-

isoenzyme Dnmt3b1

485307

-

0.0027

poly(dG-dC)-poly(dG-dC)

Mus musculus

-

isoenzyme Dnmt3a

485307

-

0.0035

poly(dG-dC)-poly(dG-dC)

Mus musculus

-

isoenzyme Dnmt3a

485307

-

0.0005

poly(dI-dC)*poly(dI-dC)

Homo sapiens

-

-

485303

-

0.0007

poly(dI-dC)*poly(dI-dC)

Homo sapiens

P26358

-

485304

-

0.0003

poly(dI-dC)-poly(dI-dC)

Mus musculus

-

isoenzyme Dnmt3a

485307

-

0.0013

poly(dI-dC)-poly(dI-dC)

Mus musculus

-

isoenzyme Dnmt3b1

485307

-

0.0015

poly(dI-dC)-poly(dI-dC)

Mus musculus

-

isoenzyme Dnmt3b2

485307

-

0.0005

poly-(dI-dC)/poly(dI-dC)

Homo sapiens

-

mutant enzyme K284A/K285A

657995

-

0.00056

poly-(dI-dC)/poly(dI-dC)

Homo sapiens

-

wild-type enzyme

657995

-

0.00082

poly-(dI-dC)/poly(dI-dC)

Homo sapiens

-

mutant enzyme H286A/R287A

657995

-

0.00011

S-adenosyl-L-methionine

Haemophilus parahaemolyticus

P05102

pH 7.5, 37°C

660052

0.00025

S-adenosyl-L-methionine

Rattus norvegicus

-

in presence of Micrococcus luteus DNA

485278

0.00028

S-adenosyl-L-methionine

Haemophilus aegyptius

P20589

pH 8.5, 37°C

660052

0.0003

S-adenosyl-L-methionine

Mus musculus

-

isoenzyme Dnmt3a, reaction with poly(dG-dC)-poly(dG-dC)

485307

0.0003

S-adenosyl-L-methionine

Mus musculus

O88508, O88509

pH 7.4, 37°C, Dnmt3a

659080

0.0004

S-adenosyl-L-methionine

Mus musculus

-

isoenzyme Dnmt3a, reaction with poly(dI-dC)-poly(dI-dC)

485307

0.0007

S-adenosyl-L-methionine

Mus musculus

O88508, O88509

pH 7.4, 37°C, Dnmt3b

659080

0.0008

S-adenosyl-L-methionine

Mus musculus

-

isoenzyme Dnmt3b2, reaction with poly(dG-dC)-poly(dG-dC)

485307

0.0009

S-adenosyl-L-methionine

Mus musculus

-

isoenzyme Dnmt3b2, reaction with poly(dI-dC)-poly(dI-dC)

485307

0.00096

S-adenosyl-L-methionine

Mus musculus

O88508, O88509

enzyme Dnmt3A, in presence of Dnmt3L

659456

0.0012

S-adenosyl-L-methionine

Mus musculus

-

isoenzyme Dnmt3b1, reaction with poly(dI-dC)-poly(dI-dC) por poly(dG-dC)*poly(dG-dC)

485307

0.00255

S-adenosyl-L-methionine

Mus musculus

O88508, O88509

enzyme Dnmt3A, in absence of Dnmt3L

659456

0.0026

S-adenosyl-L-methionine

Oryza sativa

-

-

485285

0.00263

S-adenosyl-L-methionine

Oryza sativa

B1Q3J6, Q7Y1I7

pH 7.6, 25°C

706274

0.00325

S-adenosyl-L-methionine

Homo sapiens

-

-

485275

0.0034

S-adenosyl-L-methionine

Homo sapiens

-

mutant enzyme H286A/R287A

657995

0.004

S-adenosyl-L-methionine

Homo sapiens

-

-

485286

0.004

S-adenosyl-L-methionine

Homo sapiens

P26358

reaction with (CGG‘CCG)12

485304

0.005 - 0.006

S-adenosyl-L-methionine

Triticum aestivum

-

-

485290

0.006

S-adenosyl-L-methionine

Homo sapiens

P26358

reaction with relaxed circular pRW3602

485304

0.007

S-adenosyl-L-methionine

Homo sapiens

P26358

reaction with linear pRW3602

485304

0.0072

S-adenosyl-L-methionine

Homo sapiens

-

-

485303

0.0072

S-adenosyl-L-methionine

Homo sapiens

-

wild-type enzyme

657995

0.009

S-adenosyl-L-methionine

Homo sapiens

P26358

reaction with poly(dI-dC)*poly(dI-dC)

485304

0.0092

S-adenosyl-L-methionine

Homo sapiens

-

mutant enzyme K284A/K285A

657995

0.011

S-adenosyl-L-methionine

Homo sapiens

P26358

reaction with pRW3602, supercoiled

485304

0.013

S-adenosyl-L-methionine

Mus musculus

-

-

485277

0.014

S-adenosyl-L-methionine

Homo sapiens

P26358

reaction with (CGG*CCG)73

485304

0.021

S-adenosyl-L-methionine

Chaetopterus variopedatus

-

-

485299

0.0000037

unmethylated 30-mer DNA containing cytosine

Haemophilus aegyptius

P20589

pH 8.5, 37°C

660052

-

0.000004

unmethylated 30-mer DNA containing cytosine

Haemophilus parahaemolyticus

P05102

pH 7.5, 37°C

660052

-

additional information

additional information

Mus musculus

-

-

485295

-

additional information

additional information

Homo sapiens

-

-

485303

-

additional information

additional information

Homo sapiens

-

-

657995

-

additional information

additional information

Homo sapiens

P26358

-

485304

-

additional information

additional information

Homo sapiens

-

-

485304

-

additional information

additional information

Oryza sativa

B1Q3J6

kinetics

706274

-

additional information

additional information

Oryza sativa

Q7Y1I7

kinetics

706274

-

additional information

additional information

Oryza sativa

-

kinetics

706274

-

additional information

additional information

Oryza sativa

-

Km-value for poly(dI-MedC)*poly(dI-dC): 0.017 mg/ml

485285

-

additional information

additional information

Mus musculus

-

Km-values for hybrid enzymes

485300

-

additional information

additional information

Homo sapiens

P26358

Michaelis-Menten kinetics, Dnmt1 allosteric regulation mechanism, modelling, overview

703330

-

additional information

additional information

Synechocystis sp.

-

recombinant kinetics of wild-type and mutant enzymes, overview

702450

-