2.1.1.41: sterol 24-C-methyltransferase This is an abbreviated version! For detailed information about sterol 24-C-methyltransferase, go to the full flat file .
Reaction
S-adenosyl-L-methionine +
5alpha-cholesta-8,24-dien-3beta-ol =
S-adenosyl-L-homocysteine +
24-methylene-5alpha-cholest-8-en-3beta-ol
Synonyms (S)-adenosyl-L-methionine:DELTA24(25)-sterol methyl transferase, 24-C-sterol methyltransferase, 24-SMT, 24-sterol C-methyltransferase, C-24 sterol methyltransferase, C24-methyltransferase, DELTA(24,25)-SMT, DELTA24-methyltransferase, DELTA24-sterol methyltransferase, Erg6, Erg6p, LMJF_36_2380, LMJF_36_2390, methyltransferase, DELTA24-sterol, PbSMT, phytosterol methyltransferase, S-adenosyl-4-methionine:sterol DELTA24-methyltransferase, S-adenosyl-L-methionine:DELTA24(23)-sterol methyltransferase, SAM:SMT, SMT, SMT protein, SMT1, SMT80, SMT90, sterol 24-C-methyltransferase, sterol C24-methyltransferase, sterol methyltransferase, STM, TbSMT, zymosterol 24-methyltransferase, zymosterol-24-methyltransferase
ECTree
Reaction
Reaction on EC 2.1.1.41 - sterol 24-C-methyltransferase
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S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol
S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol
mechanism
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S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol
mechanism
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S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol
substrate analogue inhibitor binding site structure
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S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol
kinetic and inhibition mechanism
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S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol
active site model, termed steric-electric plug model, consists of a non-covalent mechanism involving the intermediacy of a 24beta-methyl (or ethyl) sterol bound to the ternary complex
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S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol
active site model, termed steric-electric plug model, consists of a non-covalent mechanism involving the intermediacy of a 24beta-methyl (or ethyl) sterol bound to the ternary complex
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S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol
substrate binding, amino acid sequence
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S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol
substrate binding, amino acid sequence
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S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol
substrate binding, amino acid sequence
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S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol
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