2.1.1.44: L-histidine Nalpha-methyltransferase

This is an abbreviated version!
For detailed information about L-histidine Nalpha-methyltransferase, go to the full flat file.

Reaction

3 S-adenosyl-L-methionine +

Synonyms

dimethylhistidine methyltransferase, EgtD, histidine-alpha-N-methyltransferase, methyltransferase, histidine Nalpha-

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.44 L-histidine Nalpha-methyltransferase

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Results	in table
5087	AA Sequence
1	CAS Registry Number
1	Crystallization (Commentary)
14	Inhibitors
12	kcat/KM [mM/s]
1	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
3	Organism
4	Pathway
30	PDB ID
3	pH Optimum
4	Protein Variants
1	Purification (Commentary)
4	Reaction
1	Reaction Type
3	Reference
1	Specific Activity [micromol/min/mg]
19	Substrates and Products (Substrate)
5	Synonyms
1	Systematic Name
4	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.1.1.44 - L-histidine Nalpha-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

3 S-adenosyl-L-methionine + L-histidine

3 S-adenosyl-L-homocysteine + hercynine

2 entries

S-adenosyl-L-methionine + DOPA

S-adenosyl-L-homocysteine + ?

Mycolicibacterium smegmatis

A0R5M8

poor substrate

756445

-

-

?

S-adenosyl-L-methionine + histidine

S-adenosyl-L-homocysteine + Nalpha-methylhistidine

Neurospora crassa

-

-

441301

-

-

?

S-adenosyl-L-methionine + L-histidine

S-adenosyl-L-homocysteine + Nalpha-methyl-L-histidine

2 entries

S-adenosyl-L-methionine + L-phenylalanine

S-adenosyl-L-homocysteine + ?

Mycolicibacterium smegmatis

A0R5M8

poor substrate

756445

-

-

?

S-adenosyl-L-methionine + L-tryptophan

S-adenosyl-L-homocysteine + ?

Mycolicibacterium smegmatis

A0R5M8

poor substrate

756445

-

-

?

S-adenosyl-L-methionine + L-tyrosine

S-adenosyl-L-homocysteine + ?

Mycolicibacterium smegmatis

A0R5M8

poor substrate

756445

-

-

?

S-adenosyl-L-methionine + methylhistidine

S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine

Neurospora crassa

-

-

441301

-

-

?

S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine

S-adenosyl-L-homocysteine + hercynine

2 entries

S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine

S-adenosyl-L-homocysteine + Nalpha,Nalpha,Nalpha-trimethyl-L-histidine

Neurospora crassa

-

-

441301

-

441301

?

S-adenosyl-L-methionine + Nalpha-methyl-L-histidine

S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine

2 entries

S-adenosyl-L-methionine + Nalpha-methylhistidine

S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine

Neurospora crassa

-

-

441301

-

-

?

additional information

?

-

3 entries

3 S-adenosyl-L-methionine + L-histidine

3 S-adenosyl-L-homocysteine + hercynine

Mycolicibacterium smegmatis

A0R5M8

-

756445

-

-

?

3 S-adenosyl-L-methionine + L-histidine

3 S-adenosyl-L-homocysteine + hercynine

Mycolicibacterium smegmatis ATCC 700084

A0R5M8

-

756445

-

-

?

S-adenosyl-L-methionine + L-histidine

S-adenosyl-L-homocysteine + Nalpha-methyl-L-histidine

Mycolicibacterium smegmatis

A0R5M8

-

756445

-

-

?

S-adenosyl-L-methionine + L-histidine

S-adenosyl-L-homocysteine + Nalpha-methyl-L-histidine

Mycolicibacterium smegmatis ATCC 700084

A0R5M8

-

756445

-

-

?

S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine

S-adenosyl-L-homocysteine + hercynine

Mycolicibacterium smegmatis

A0R5M8

-

756445

-

-

?

S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine

S-adenosyl-L-homocysteine + hercynine

Mycolicibacterium smegmatis ATCC 700084

A0R5M8

-

756445

-

-

?

S-adenosyl-L-methionine + Nalpha-methyl-L-histidine

S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine

Mycolicibacterium smegmatis

A0R5M8

-

756445

-

-

?

S-adenosyl-L-methionine + Nalpha-methyl-L-histidine

S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine

Mycolicibacterium smegmatis ATCC 700084

A0R5M8

-

756445

-

-

?

additional information

?

-

Mycolicibacterium smegmatis

A0R5M8

EgtD is a four- and 70-times stronger binder of Nalpha-methylhistidine and N-alpha-dimethylhistidine, respectively, than of histidine

756445

-

-

-

additional information

?

-

Mycolicibacterium smegmatis ATCC 700084

A0R5M8

EgtD is a four- and 70-times stronger binder of Nalpha-methylhistidine and N-alpha-dimethylhistidine, respectively, than of histidine

756445

-

-

-

additional information

?

-

Neurospora crassa

-

conversion of histidine to hercynine is mediated either by one enzyme or by two or three enzymes with chemical and physical properties so similar that common methods of protein fractionation fail to effect any separation

441301

-

-

?