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2.1.1.45: thymidylate synthase

This is an abbreviated version!
For detailed information about thymidylate synthase, go to the full flat file.

Word Map on EC 2.1.1.45

Reaction

5,10-methylenetetrahydrofolate
+
dUMP
=
dihydrofolate
 +
dTMP

Synonyms

BgDHFR-TS, bifunctional TS-DHFR, DFR-TS, DHFR-TS, DHFR–TS, dihydrofolate reductase-thymidylate synthase, dTMP synthase, HTS, human TS, LBRM_06_0830, methylenetetrahydrofolate:dUMP C-methyltransferase, More, Thy1, ThyA, thymidylate synthase, thymidylate synthase A, thymidylate synthase-dihydrofolate reductase, thymidylate synthetase, ThyX, TMP synthetase, TMPS, TS, TS-DHFR, TSase, TYMS, Y110A7A.4

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.45 thymidylate synthase

Temperature Stability

Temperature Stability on EC 2.1.1.45 - thymidylate synthase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
38
-
unstable above
40
-
TS activity at 40°C falls rapidly with time
43
-
fairly stable, incubation for 10 min results in loss of 50% enzyme activity
50
-
fairly stable, incubation for 10 min results in loss of 50% enzyme activity
52
-
wild-type enzyme, precipitates at 52°C
90
-
mutant enzyme remains soluble, enhancement of activity is observed up to 60°C, possesses appreciable enzymatic activity at 65°C and retains secondary structure even at 90°C