2.1.1.45: thymidylate synthase

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For detailed information about thymidylate synthase, go to the full flat file.

Word Map on EC 2.1.1.45

2.1.1.45

5-fluorouracil

thymidine

colorectal

dihydrofolate

antifolate

methotrexate

dihydropyrimidine

pyrimidine

fluoropyrimidine

phosphorylase

ribonucleotide

leucovorin

pemetrexed

resect

fdump

uracil

mthfr

casey

schedule

polyglutamates

non-small

cisplatin

folylpolyglutamate

deoxyuridine

oxaliplatin

5-fluoro-2'-deoxyuridine

antimetabolite

orotate

irinotecan

capecitabine

5-fu-based

ccrf-cem

folate-dependent

gemcitabine

folinic

formyltransferase

quinazoline

glycinamide

dttp

polyglutamylation

2'-deoxyuridine

tegafur

medicine

methotrexate-resistant

deoxycytidylate

cross-complementing

drug development

transformylase

5-fu-induced

dutpase

aminopterin

deoxythymidine

Reaction

Synonyms

BgDHFR-TS, bifunctional TS-DHFR, DFR-TS, DHFR-TS, DHFR�TS, dihydrofolate reductase-thymidylate synthase, dTMP synthase, HTS, human TS, LBRM_06_0830, methylenetetrahydrofolate:dUMP C-methyltransferase, More, Thy1, ThyA, thymidylate synthase, thymidylate synthase A, thymidylate synthase-dihydrofolate reductase, thymidylate synthetase, ThyX, TMP synthetase, TMPS, TS, TS-DHFR, TSase, TYMS, Y110A7A.4

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.45 thymidylate synthase

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Results	in table
24	Activating Compound
35645	AA Sequence
100	Application
1	CAS Registry Number
67	Cloned(Commentary)
155	Cofactor
62	Crystallization (Commentary)
7739	Disease/ Diagnostics
7	Expression
25	General Information
16	General Stability
186	IC50 Value
1137	Inhibitors
13	kcat/KM [mM/s]
140	Ki Value [mM]
185	KM Value [mM]
5	Localization
14	Metals/Ions
103	Molecular Weight [Da]
322	Natural Substrates/ Products (Substrates)
2481	Organism
14	Pathway
665	PDB ID
36	pH Optimum
8	pH Range
4	pH Stability
3	Posttranslational Modification
58	Protein Variants
104	Purification (Commentary)
2	Reaction
13	Reaction Type
509	Reference
150	Source Tissue
50	Specific Activity [micromol/min/mg]
31	Storage Stability
891	Substrates and Products (Substrate)
137	Subunits
78	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
4	Temperature Range [°C]
10	Temperature Stability [°C]
23	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 2.1.1.45 - thymidylate synthase

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5.9

Lacticaseibacillus casei

UMP as substrate

6.5 - 6.7

6.5 - 6.8

6.5 - 7

6.5 - 8

6.6

6.6 - 6.8

6.7

6.8 - 7.2

Saccharomyces cerevisiae

6.8 - 8.7

7 - 7.7

Streptococcus pneumoniae

7 - 8

7 - 8.1

7.2 - 7.4

double pH-optimum in 2-N-morpholinoethane sulfonic acid buffer

485362

7.3 - 8

Rattus norvegicus

half-maximal activity at pH 6.3

7.5

7.5 - 8

7.8