2.1.1.5: betaine-homocysteine S-methyltransferase

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For detailed information about betaine-homocysteine S-methyltransferase, go to the full flat file.

Reaction

Synonyms

betaine homocysteine methyltransferase, betaine homocysteine methyltransferase-1, betaine homocysteine S-methyltransferase, betaine-homocysteine methyltransferase, betaine-homocysteine S-methyltransferase, betaine-homocysteine S-methyltransferase 2, betaine-homocysteine S-methyltransferase-2, betaine-homocysteine transmethylase, betaine:homocysteine methyltransferase, betaine:homocysteine S-methyltransferase, BHMT, BHMT-1, BHMT-2, BHMT1, BHMT2, methyltransferase, betaine-homocysteine

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.5 betaine-homocysteine S-methyltransferase

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Results	in table
28	Activating Compound
724	AA Sequence
25	Application
1	CAS Registry Number
10	Cloned(Commentary)
7	Crystallization (Commentary)
168	Disease/ Diagnostics
6	Expression
7	General Information
8	General Stability
14	IC50 Value
100	Inhibitors
4	kcat/KM [mM/s]
3	Ki Value [mM]
58	KM Value [mM]
12	Localization
11	Metals/Ions
14	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
311	Organism
1	Oxidation Stability
8	Pathway
16	PDB ID
10	pH Optimum
1	pH Stability
1	pI Value
1	Posttranslational Modification
60	Protein Variants
11	Purification (Commentary)
4	Reaction
1	Reaction Type
89	Reference
105	Source Tissue
13	Specific Activity [micromol/min/mg]
6	Storage Stability
50	Substrates and Products (Substrate)
12	Subunits
78	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
37	Turnover Number [1/s]

Cloned

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Cloned on EC 2.1.1.5 - betaine-homocysteine S-methyltransferase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

3 entries

a 2.7 kb 5'-flanking region of the human BHMT gene cloned between MluI and SmaI sites of a promoterless pGL-3-basic vector creating the recombinant plasmid -2698/+33 BHMT-LUC, expression in HepG2 cells

Homo sapiens

Q6EI07

671886

expressed in COS-1 cells and in Escherichia coli

Homo sapiens

-

689024

expressed in Escherichia coli BL21(DE3) (coexpression of human recombinant betaine-homocysteine S-methyltransferase)

Homo sapiens

-

720202

expressed in Hep-G2 cell

Homo sapiens

Q93088

719035

glutathione S-transferase-BHMT fusion protein is expressed in HEK-293, T98G, A-10, MCF-7, H-1299, C2C12, and NIH-3T3 cells

Homo sapiens

-

701995

impossible to express BHMT2 in mammalian cells, protein aggregates after bacterial expression. BHMT2 is rapidly degraded in a rabbit reticulocyte lysate, but it can be stabilized by cotransfection of COS-1 cells with BHMT and, after cotransfection, it coprecipitates with BHMT

Homo sapiens

-

689024

transiently expressed in HepG2-cells and primary mouse hepatocytes

Homo sapiens

Q93088

687005

-

Rattus norvegicus

-

658186

-

Homo sapiens

Q93088

441243, 735230

-

Homo sapiens

-

735230