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2.1.1.56: mRNA (guanine-N7)-methyltransferase

This is an abbreviated version!
For detailed information about mRNA (guanine-N7)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.56

Reaction

S-adenosyl-L-methionine
+
a 5'-(5'-triphosphoguanosine)-[mRNA]
=
S-adenosyl-L-homocysteine
+
a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA]

Synonyms

(guanine-N7)-methyltransferase, Abd1, alphavirus capping enzyme, cap methyltransferase, cap N7-MTase, cap N7MTase, cap-methyltransferase, DENV methyltransferase, DENV-4 NS5, Ecm1, guanine-7-methyltransferase, guanine-N-7 methyltransferase, guanine-N7 methyltransferase, guanosine-7-methyltransferase, messenger ribonucleate guanine 7-methyltransferase, messenger RNA guanine 7-methyltransferase, methyltransferase domain of Sudan ebolavirus L protein, methyltransferase, messenger ribonucleate guanine 7-, mRNA cap (guanine N-7) methyltransferase, mRNA cap (guanine N-7) MTase, mRNA cap (guanine-N7) methyltransferase, mRNA cap methyltransferase, mRNA guanosine cap by RNA guanine-7-methyltransferase, MTase+CTD, N-7-MTase, N7 methyltransferase, N7 MTase, N7-methyltransferase, N7-MTase, non-structural protein 1, nonstructural protein 14, nonstructural protein 5 methyltransferase, NS5, NS5MTase, nsp 14, nsP1 methyltransferase, nsP1 MTase, nsp14, RNA (guanine-N7) methyltransferase, RNA cap (guanine N-7) methyltransferase, RNA guanine-7 methyltransferase, RNA guanine-7-methyltransferase, RNA guanine-methyltransferase, RNA guanine-N7 methyltransferase, RNA N7-MTase, RNMT, TbCgm1, TbCmt1

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.56 mRNA (guanine-N7)-methyltransferase

IC50 Value

IC50 Value on EC 2.1.1.56 - mRNA (guanine-N7)-methyltransferase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1022
(2-[4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl]ethoxy)acetic acid
Homo sapiens
-
at pH 8.0 and 30°C
0.0184
(2R,6S)-2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine
Severe acute respiratory syndrome-related coronavirus
-
at pH 8.0 and 30°C
0.00005 - 0.002
1,8-dihydroxyanthracen-9(10H)-one
0.00128 - 0.011
1-(4-tert-butylphenyl)-N-methyl-N-[(naphthalen-1-yl)methyl]methanamine
0.159
1-(diphenylmethyl)-4-methylpiperazine hydrochloride (1:1)
Homo sapiens
-
at pH 8.0 and 30°C
0.0091 - 0.0168
1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
0.2268
1-[(4-chlorophenyl)(phenyl)methyl]-4-methylpiperazine
Homo sapiens
-
at pH 8.0 and 30°C
0.0062 - 0.0088
1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine
0.0135 - 0.0137
1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine
0.0073 - 0.0143
1-[bis(4-fluorophenyl)methyl]-4-[(2Z)-3-phenylprop-2-en-1-yl]piperazine
0.000019
2,3,7,8-tetrahydroxy[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione
Severe acute respiratory syndrome-related coronavirus
-
at pH 8.0 and 30°C
0.03652
2-(2-[4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl]ethoxy)ethan-1-ol
Homo sapiens
-
at pH 8.0 and 30°C
0.00032 - 0.00074
3,3',4',5,5',7-hexahaxdroxyflavone
0.0004 - 0.0013
3,3',4',5,7-pentahydroxyflavone
0.01 - 0.0237
3,4',5,7-tetrahydroxyflavone
0.0055 - 0.031
3,8-diamino-5-[3-[diethyl(methyl)azaniumyl]propyl]-6-phenylphenanthridin-5-ium
0.0023 - 0.00572
aurintricarboxylic acid
0.1
aza-S-adenosyl-L-methionine
Encephalitozoon cuniculi
-
0.0045 - 0.0051
bis[6-(dimethylamino)-2-[(E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methylquinolin-1-ium] 4-[(3-carboxy-2-oxidonaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylate
0.035
carbocyclic aza-S-adenosyl-L-methionine
Encephalitozoon cuniculi
-
0.001 - 0.0015
N-(2-[[(4-methoxyphenyl)methyl](pyrimidin-2-yl)amino]ethyl)-N,N-dimethylhexadecan-1-aminium
1.18
ribavirin
Chikungunya virus
at pH 7.3 and 25°C
0.00177
S-adenosyl-homocysteine
Dengue virus
-
pH 7.5, 20°C
0.004 - 0.021
S-adenosyl-L-homocysteine
0.000021 - 0.00269
sinefungin