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2.1.1.57: methyltransferase cap1

This is an abbreviated version!
For detailed information about methyltransferase cap1, go to the full flat file.

Word Map on EC 2.1.1.57

Reaction

S-adenosyl-L-methionine
+
a 5'-(N7-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA]
=
S-adenosyl-L-homocysteine
+
a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]

Synonyms

(nucleoside-2'-O-)-methyltransferase, (nucleoside-2'O)-methyltransferase, 2'-O methyltransferase, 2'-O MTase, 2'-O-methyltransferase, 2'-O-MTase, 2'O methyltransferase, 2'O-MTase, 2'OMTases, cap-specific 2'-O-methyltransferase, cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, cap1 2-O'-ribose methyltransferase, CMTr1, EC 2.1.1.58, FtsJ methyltransferase domain-containing 2, FTSJD2, ISG95, KIAA0082, L protein domain VI, large polymerase protein domain VI, messenger ribonucleate nucleoside 2'-methyltransferase, messenger RNA (nucleoside-2'-)-methyltransferase, methyltransferase, messenger ribonucleate nucleoside 2'-, mRNA (nucleoside-2'-O)-methyltransferase, mRNA 5' cap-specific (nucleoside-2'-O)-methyltransferase, mRNA cap (nucleoside-2'-O)-methyltransferase, mRNA cap methyltransferase, mRNA cap-specific 2'-O-methyltransferase, MT57, Mtr1, nonstructural protein 16, nonstructural protein 16 methyltransferase, nonstructural protein 5 methyltransferase, NS5, NS5 MTase, NS5MTase, nsp10/16 complex, nsp10/nsp16 complex, nsp16, nsp16 protein, nsp16/nsp10 protein complex, ribose 2'-O methyltransferase, RNA (nucleoside-2'O)-methyltransferase, RNA cap 2'-O-methyltransferase, RNA cap 2'-O-MTase, RNA cap 2'O-MTase, RNA cap1 methyltransferase, RNA capping enzyme domain in protein A, S-adenosyl-L-methionine-dependent mRNA cap MTase, TbMT48, TbMT57, VP39, VP4

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.57 methyltransferase cap1

Reference

Reference on EC 2.1.1.57 - methyltransferase cap1

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pugh, C.S.G.; Borchardt, R.T.
Effects of S-adenosylhomocysteine analogues on vaccinia viral messenger ribonucleic acid synthesis and methylation
Biochemistry
21
1535-1541
1982
Vaccinia virus, Vaccinia virus WR
Manually annotated by BRENDA team
Ensinger, M.J.; Martin, S.A.; Paoletti, E.; Moss, B.
Modification of the 5-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus
Proc. Natl. Acad. Sci. USA
72
2525-2529
1975
Vaccinia virus, Vaccinia virus WR
Manually annotated by BRENDA team
Ramadevi, N.; Burroughs, N.J.; Mertens, P.P.C.; Jones, I.M.
Capping and methylation of mRNA by purified recombinant VP4 protein of bluetongue virus
Proc. Natl. Acad. Sci. USA
95
13537-13542
1998
bluetongue virus
Manually annotated by BRENDA team
Barbosa, E.; Moss, B.
mRNA(nucleoside-2-)-methyltransferase from vaccinia virus. Purification and physical properties
J. Biol. Chem.
253
7692-7697
1978
Vaccinia virus, Vaccinia virus WR
Manually annotated by BRENDA team
Barbosa, E.; Moss, B.
mRNA(nucleoside-2-)-methyltransferase from vaccinia virus. Characteristics and substrate specificity
J. Biol. Chem.
253
7698-7702
1978
Vaccinia virus, Vaccinia virus WR
Manually annotated by BRENDA team
Pugh, C.S.G.; Borchardt, R.T.; Stone, H.O.
Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2-)-methyltransferase, and viral multiplication
J. Biol. Chem.
253
4075-4077
1978
Vaccinia virus, Vaccinia virus WR
Manually annotated by BRENDA team
Langberg, S.R.; Moss, B.
Post-transcriptional modifications of mRNA. Purification and characterization of cap I and cap II RNA (nucleoside-2-)-methyltransferases from HeLa cells
J. Biol. Chem.
256
10054-10060
1981
Homo sapiens
Manually annotated by BRENDA team
Schnierle, B.S.; Gershon, P.; Moss, B.
Cap-specific mRNA (nucleoside-O2-)-methyltransferase and poly(A) polymerase stimulatory activities of vaccinia virus are mediated by a single protein
Proc. Natl. Acad. Sci. USA
89
2897-2901
1992
Vaccinia virus, Vaccinia virus WR
Manually annotated by BRENDA team
Boone, R.F.; Ensinger, M.J.; Moss, B.
Synthesis of mRNA guanylyltransferase and mRNA methyltransferases in cells infected with vaccinia virus
J. Virol.
21
475-483
1977
Homo sapiens
Manually annotated by BRENDA team
Lockless, S.W.; Cheng, H.T.; Hodel, A.E.; Quiocho, F.A.; Gershon, P.D.
Recognition of capped RNA substrates by VP39, the vaccinia virus-encoded mRNA cap-specific 2'-O-methyltransferase
Biochemistry
37
8564-8574
1998
Vaccinia virus
Manually annotated by BRENDA team
Egloff, M.P.; Benarroch, D.; Selisko, B.; Romette, J.L.; Canard, B.
An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization
EMBO J.
21
2757-2768
2002
Dengue virus (P12823)
Manually annotated by BRENDA team
Schnierle, B.S.; Gershon, P.D.; Moss, B.
Mutational analysis of a multifunctional protein, with mRNA 5' cap-specific (nucleoside-2'-O-)-methyltransferase and 3'-adenylyltransferase stimulatory activities, encoded by vaccinia virus
J. Biol. Chem.
269
20700-20706
1994
Vaccinia virus
Manually annotated by BRENDA team
Latner, D.R.; Xiang, Y.; Lewis, J.I.; Condit, J.; Condit, R.C.
The vaccinia virus bifunctional gene J3 (nucleoside-2'-O-)-methyltransferase and poly(A) polymerase stimulatory factor is implicated as a positive transcription elongation factor by two genetic approaches
Virology
269
345-355
2000
Vaccinia virus
Manually annotated by BRENDA team
Hu, G.; Tsai, A.L.; Quiocho, F.A.
Insertion of an N7-methylguanine mRNA cap between two coplanar aromatic residues of a cap-binding protein is fast and selective for a positively charged cap
J. Biol. Chem.
278
51515-51520
2003
Vaccinia virus
Manually annotated by BRENDA team
Benarroch, D.; Egloff, M.P.; Mulard, L.; Guerreiro, C.; Romette, J.L.; Canard, B.
A structural basis for the inhibition of the NS5 Dengue Virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate
J. Biol. Chem.
279
35638-35643
2004
Dengue virus (P12823), Dengue virus
Manually annotated by BRENDA team
Mastrangelo, E.; Bollati, M.; Milani, M.; de Lamballeire, X.; Brisbare, N.; Dalle, K.; Lantez, V.; Egloff, M.P.; Coutard, B.; Canard, B.; Gould, E.; Forrester, N.; Bolognesi, M.
Preliminary characterization of (nucleoside-2-O-)-methyltransferase crystals from Meaban and Yokose flaviviruses
Acta Crystallogr. Sect. F
F62
768-770
2006
Meaban virus, Yokose virus
Manually annotated by BRENDA team
Li, C.; Gershon, P.D.
pKa of the mRNA cap-specific 2-O-methyltransferase catalytic lysine by HSQC NMR detection of a two-carbon probe
Biochemistry
45
907-917
2006
Vaccinia virus (P07617)
Manually annotated by BRENDA team
Li, J.; Fontaine-Rodriguez, E.C.; Whelan, S.P.
Amino acid residues within conserved domain VI of the vesicular stomatitis virus large polymerase protein essential for mRNA cap methyltransferase activity
J. Virol.
79
13373-13384
2005
vesicular stomatitis virus
Manually annotated by BRENDA team
Arhin, G.K.; Li, H.; Ullu, E.; Tschudi, C.
A protein related to the vaccinia virus cap-specific methyltransferase VP39 is involved in cap 4 modification in Trypanosoma brucei
RNA
12
53-62
2006
Trypanosoma brucei (Q385S9), Trypanosoma brucei (Q38DJ3), Trypanosoma brucei
Manually annotated by BRENDA team
Selisko, B.; Peyrane, F.F.; Canard, B.; Alvarez, K.; Decroly, E.
Biochemical characterization of the (nucleoside-2'O)-methyltransferase activity of dengue virus protein NS5 using purified capped RNA oligonucleotides (7Me)GpppAC(n) and GpppAC(n)
J. Gen. Virol.
91
112-121
2010
Dengue virus, feline coronavirus
Manually annotated by BRENDA team
Belanger, F.; Stepinski, J.; Darzynkiewicz, E.; Pelletier, J.
Characterization of hMTr1, a human Cap1 2-O’-ribose methyltransferase
J. Biol. Chem.
285
33037-33044
2010
Homo sapiens
Manually annotated by BRENDA team
Lugari, A.; Betzi, S.; Decroly, E.; Bonnaud, E.; Hermant, A.; Guillemot, J.C.; Debarnot, C.; Borg, J.P.; Bouvet, M.; Canard, B.; Morelli, X.; Lecine, P.
Molecular mapping of the RNA cap 2'-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16
J. Biol. Chem.
285
33230-33241
2010
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Decroly, E.; Debarnot, C.; Ferron, F.; Bouvet, M.; Coutard, B.; Imbert, I.; Gluais, L.; Papageorgiou, N.; Sharff, A.; Bricogne, G.; Ortiz-Lombardia, M.; Lescar, J.; Canard, B.
Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2’-O-methyltransferase nsp10/nsp16 complex
PLoS Pathog.
7
e1002059
2011
Severe acute respiratory syndrome-related coronavirus
Manually annotated by BRENDA team
Chen, Y.; Su, C.; Ke, M.; Jin, X.; Xu, L.; Zhang, Z.; Wu, A.; Sun, Y.; Yang, Z.; Tien, P.; Ahola, T.; Liang, Y.; Liu, X.; Guo, D.
Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2-O-methylation by nsp16/nsp10 protein complex
PLoS Pathog.
7
e1002294
2011
Severe acute respiratory syndrome-related coronavirus (G8H306), Severe acute respiratory syndrome-related coronavirus, Severe acute respiratory syndrome-related coronavirus WHU (G8H306)
Manually annotated by BRENDA team
Szretter, K.J.; Daniels, B.P.; Cho, H.; Gainey, M.D.; Yokoyama, W.M.; Gale, M.; Virgin, H.W.; Klein, R.S.; Sen, G.C.; Diamond, M.S.
2-O methylation of the viral mRNA cap by West Nile virus evades Ifit1-dependent and -independent mechanisms of host restriction in vivo
PLoS Pathog.
8
e1002698
2012
West Nile virus
Manually annotated by BRENDA team
Chung, K.Y.; Dong, H.; Chao, A.T.; Shi, P.Y.; Lescar, J.; Lim, S.P.
Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2-O methyltransferase activity in dengue virus
Virology
402
52-60
2010
Dengue virus
Manually annotated by BRENDA team
Zhang, X.; Wei, Y.; Ma, Y.; Hu, S.; Li, J.
Identification of aromatic amino acid residues in conserved region VI of the large polymerase of vesicular stomatitis virus is essential for both guanine-N-7 and ribose 2-O methyltransferases
Virology
408
241-252
2010
vesicular stomatitis virus
Manually annotated by BRENDA team
Ke, M.; Chen, Y.; Wu, A.; Sun, Y.; Su, C.; Wu, H.; Jin, X.; Tao, J.; Wang, Y.; Ma, X.; Pan, J.A.; Guo, D.
Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2'-O-methyltransferase activity of nsp10/nsp16 complex
Virus Res.
167
322-328
2012
Severe acute respiratory syndrome-related coronavirus, Severe acute respiratory syndrome-related coronavirus WHU
Manually annotated by BRENDA team
Stewart, M.E.; Roy, P.
Structure-based identification of functional residues in the nucleoside-2-O-methylase domain of Bluetongue virus VP4 capping enzyme
FEBS open bio
5
138-146
2015
bluetongue virus (C5IWW0), bluetongue virus
Manually annotated by BRENDA team
Simabuco, F.M.; Pavan, I.C.B.; Pestana, N.F.; Carvalho, P.C.; Basei, F.L.; Campos Granato, D.; Paes Leme, A.F.; Zanchin, N.I.T.
Interactome analysis of the human cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (hMTr1) protein
J. Cell. Biochem.
120
5597-5611
2019
Homo sapiens (Q8N1G2), Homo sapiens
Manually annotated by BRENDA team
Toczydlowska-Socha, D.; Zielinska, M.M.; Kurkowska, M.; Astha, M.; Almeida, C.F.; Stefaniak, F.; Purta, E.; Bujnicki, J.M.
Human RNA cap1 methyltransferase CMTr1 cooperates with RNA helicase DHX15 to modify RNAs with highly structured 5 termini
Philos. Trans. R. Soc. Lond. B Biol. Sci.
373
20180161
2018
Homo sapiens
Manually annotated by BRENDA team
Quirin, T.; Chen, Y.; Pietilae, M.K.; Guo, D.; Ahola, T.
The RNA capping enzyme domain in protein A is essential for flock house virus replication
Viruses
10
483
2018
Flock house virus
Manually annotated by BRENDA team