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2.1.1.6: catechol O-methyltransferase

This is an abbreviated version!
For detailed information about catechol O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.6

Reaction

S-adenosyl-L-methionine
+
a catechol
=
S-adenosyl-L-homocysteine
 +
a guaiacol

Synonyms

catechol methyltransferase, catechol-O-methyl transferase, catechol-O-methyl transferase, membrane bound, catechol-O-methyl transferase, soluble, catechol-O-methyltransferase, catechol-O-transferase, catecholamine O-methyltransferase, COMT, COMT I, COMT II, COMT-mb, COMT-s, COMT1, COMT2, CTOMT1, L-COMT, MB-COMT, methyltransferase, catechol, S-COMT, SCOMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.6 catechol O-methyltransferase

Cloned

Cloned on EC 2.1.1.6 - catechol O-methyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
expressed in Escherichia coli BL21 Codon Plus (DE3) cells
expressed in HEK-293 cells
-
expression in Escherichia coli
expression in Pichia pastoris
expression of membrane-bound and soluble form, in HEK-293 cell
expression of the human soluble and membrane-bound COMTs (S-COMT and MBCOMT, respectively) in Escherichia coli. The two recombinant human COMTs are functionally active, with catalytic and kinetic properties nearly identical to that of crude or purified enzymes prepared from human tissues or cells
-
gene expressed in Escherichia coli
-
generation of transgenic mice overexpressing a human COMT-Val polymorphism
His-tagged protein expressed in Escherichia coli BL21(DE3)
-
S-COMT and MB-COMT are encoded by a single gene with two different sites of transcription initiation, overview on genetic polymorphism
soluble part from M44 to S264 expressed in Escherichia coli W3110[pREP4]
-