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2.1.1.6: catechol O-methyltransferase

This is an abbreviated version!
For detailed information about catechol O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.6

Reaction

S-adenosyl-L-methionine
+
a catechol
=
S-adenosyl-L-homocysteine
 +
a guaiacol

Synonyms

catechol methyltransferase, catechol-O-methyl transferase, catechol-O-methyl transferase, membrane bound, catechol-O-methyl transferase, soluble, catechol-O-methyltransferase, catechol-O-transferase, catecholamine O-methyltransferase, COMT, COMT I, COMT II, COMT-mb, COMT-s, COMT1, COMT2, CTOMT1, L-COMT, MB-COMT, methyltransferase, catechol, S-COMT, SCOMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.6 catechol O-methyltransferase

Expression

Expression on EC 2.1.1.6 - catechol O-methyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
4-(tert-octyl)phenol, benzyl butyl phthalate, diisononyl phthalate, dibutyl phthalate, and dioctyl phthalate inhibit S-COMT protein expression in MCF-7 cells at 72 h, the inhibitory effect is abolished in the presence of the anti-estrogen ICI182780
-
COMT protein expression is down-regulated in the midsecretory phase of the menstrual cycyle, progesterone down-regulates soluble COMT protein expression
-
COMT protein expression is up-regulated in the proliferative phase of the menstrual cycyle, estrogen up-regulates soluble COMT protein expression
-
COMT protein expression levels are statistically significantly reduced by both, catechol and phenolic metabolites of polychlorinated biphenyls: 2,5-dichlorobiphenyl, 2',5'-dichlorobiphenyl-2-ol, 2',5'-dichlorobiphenyl-2,3-diol, 2',5'-dichlorobiphenyl-3,4-diol, 2',5'-dichlorobiphenyl-4-ol, 2',4'-dichlorobiphenyl-4-ol, 2',4',6'-trichlorobiphenyl-4-ol, 2',4',6'-trichlorobiphenyl-3,4-diol, and 2',4',5'-trichlorobiphenyl-3,4-diol. The changes in COMT expression are abolished in the presence of the anti-estrogen ICI182780
-
low salinity conditions lead to a significant increase in expression of COMT transcripts in the guts at 24 h, 48 h, 1 week and 2 weeks, gills at 24 h and in the muscle tissues at 48 h, with maximum expression of the COMT levels by 5fold in guts (1 week),1fold in gills (24 h) and 1.5fold in muscle (48 h), respectively
there are no effects of gonadectomy itself on COMT-s activity, there are significant effects of hormone replacement (supplementation with testosterone propionate or with estradiol for 28 days) but not gonadectomy on the soluble but not the membrane-bound isoform of catechol-O-methyltransferase in both striatum and brain cortex
-