2.1.1.6: catechol O-methyltransferase
This is an abbreviated version!
For detailed information about catechol O-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.6
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2.1.1.6
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dopamine
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val158met
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catechols
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parkinson
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monoamine
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dopaminergic
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schizophrenia
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prefrontal
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levodopa
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estrogen
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val
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o-methylation
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psychiatric
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norepinephrine
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entacapone
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l-dopa
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tolcapone
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serotonin
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noradrenaline
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dyskinesia
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neurotransmitter
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striatal
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psycho
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dopac
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carbidopa
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verbal
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3,4-dihydroxyphenylacetic
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extraneuronal
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5-httlpr
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low-activity
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parkinsonian
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homovanillic
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normetanephrine
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benserazide
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antiparkinsonian
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synthesis
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endophenotype
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dsm-iv
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3h-noradrenaline
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2-methoxyestradiol
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analysis
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tropolone
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updrs
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slc6a4
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dihydroxyphenylacetic
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amantadine
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pargyline
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oxidase-b
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phenylethanolamine-n-methyltransferase
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metanephrine
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selegiline
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medicine
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antisocial
- 2.1.1.6
- dopamine
-
val158met
- catechols
- parkinson
-
monoamine
-
dopaminergic
-
schizophrenia
-
prefrontal
- levodopa
- estrogen
- val
-
o-methylation
-
psychiatric
- norepinephrine
- entacapone
- l-dopa
- tolcapone
- serotonin
- noradrenaline
- dyskinesia
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neurotransmitter
- striatal
-
psycho
-
dopac
- carbidopa
-
verbal
-
3,4-dihydroxyphenylacetic
-
extraneuronal
-
5-httlpr
-
low-activity
-
parkinsonian
-
homovanillic
- normetanephrine
- benserazide
-
antiparkinsonian
- synthesis
-
endophenotype
-
dsm-iv
-
3h-noradrenaline
- 2-methoxyestradiol
- analysis
- tropolone
-
updrs
-
slc6a4
-
dihydroxyphenylacetic
- amantadine
- pargyline
-
oxidase-b
-
phenylethanolamine-n-methyltransferase
- metanephrine
- selegiline
- medicine
-
antisocial
Reaction
Synonyms
catechol methyltransferase, catechol-O-methyl transferase, catechol-O-methyl transferase, membrane bound, catechol-O-methyl transferase, soluble, catechol-O-methyltransferase, catechol-O-transferase, catecholamine O-methyltransferase, COMT, COMT I, COMT II, COMT-mb, COMT-s, COMT1, COMT2, CTOMT1, L-COMT, MB-COMT, methyltransferase, catechol, S-COMT, SCOMT
ECTree
2.1.1.6 catechol O-methyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.1.1.6 - catechol O-methyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-hydroxyestradiol + S-adenosyl-L-methionine
(17beta)-estra-1(10),2,4-triene-3,4,17-triol + S-adenosyl-L-homocysteine + ?
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MCF-10F cells oxidize 4-hydroxyestradiol to estrone (estradiol)-3,4-quinones, which react with DNA to form the depurinating N3Ade and N7Gua adducts
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4-hydroxyestradiol + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
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in the mammary gland, catechol estrogens are predominately inactivated by catechol-O-methyltransferase. in the isoflavone-induced. The estrogen receptor is involved in the down-regulation of COMT expression
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additional information
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activity in cells expressing norepinephrine transporter
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additional information
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comparison of wild type and variant isoforms and implications for estrogen levels
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additional information
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physiological role is the inactivation of catecholamine hormones and neurotransmitters as well as detoxification of a variety of xenobiotic amines and drugs
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additional information
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key enzyme in the elemination of dopamine in the prefrontal cortex of the human brain. Genetic variation in COMT gene (MIM 116790) is associated with altered prefrontal cortex function and higher risk for schizophrenia. A common single-nucleotide polymorphism within COMT, Val158Met, significantly affects protein abundance and enzyme activity but not mRNA expression levels. Val is a predominant factor that determines higher COMT activity in the prefrontal cortex, which presumably leads to lower synaptic dopamine levels and relatively deleterious prefrontal function
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additional information
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the enzyme plays an important role in the inactivation potentially genotoxic catechol estrogens
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additional information
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increased COMT enzyme activity in transgenic mice overexpressing a human COMT-Val polymorphism (Val-tg mice) results in disrupted attentional set-shifting abilities, and impaired working and recognition memory, but blunted stress responses and pain sensitivity. COMT disruption improves working memory, but increased stress responses and pain sensitivity. The COMT gene has a critical role in an apparent evolutionary trade-off between cognitive and affective functions
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additional information
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increased COMT enzyme activity in transgenic mice overexpressing a human COMT-Val polymorphism (Val-tg mice) results in disrupted attentional set-shifting abilities, and impaired working and recognition memory, but blunted stress responses and pain sensitivity. COMT disruption improves working memory, but increased stress responses and pain sensitivity. The COMT gene has a critical role in an apparent evolutionary trade-off between cognitive and affective functions
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additional information
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prepulse inhibition of the startle reflex depends on the catechol O-methyltransferase Val158Met gene polymorphism
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additional information
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While homozygous catechol-O-methyltransferase deletion results in improvement in spatial learning/working memory with little effect on social behavior, heterozygous deletion results in impairment of recognition memory. Catechol-O-methyltransferase and neuregulin-1 may influence, respectively, primarily cognitive and social endophenotypes of the overall schizophrenia syndrome
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additional information
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constitutive enzyme may play an important role in detoxification of polycyclic aromatic hydrocarbons
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additional information
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physiological role is the inactivation of catecholamine hormones and neurotransmitters as well as detoxification of a variety of xenobiotic amines and drugs
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additional information
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physiological role is the inactivation of catecholamine hormones and neurotransmitters as well as detoxification of a variety of xenobiotic amines and drugs
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additional information
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membrane protein and (or) lipid components may play an important role in catecholamine metabolism
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additional information
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primary role in extraneuronal inactivation of endogenous catecholamines and in the further metabolism of oxidized catecholamine metabolites
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additional information
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COMT in the adrenal gland might not be related to blood pressure regulation
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