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2.1.1.62: mRNA (2'-O-methyladenosine-N6-)-methyltransferase

This is an abbreviated version!
For detailed information about mRNA (2'-O-methyladenosine-N6-)-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
a 5-(N7-methyl 5-triphosphoguanosine)-2'-O-methyladenosine-[mRNA]
=
S-adenosyl-L-homocysteine
+
a 5-(N7-methyl 5-triphosphoguanosine)-N6,2'-O-dimethyladenosine-[mRNA]

Synonyms

cap-dependent 2'-O-methyltransferase, messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase, mRNA cap (nucleoside-2'O)-methyltransferase, NS5MTaseDV, VP39

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.62 mRNA (2'-O-methyladenosine-N6-)-methyltransferase

Substrates Products

Substrates Products on EC 2.1.1.62 - mRNA (2'-O-methyladenosine-N6-)-methyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 7MeGpppAC5
S-adenosyl-L-homocysteine + 7MeGpppA2'OMeC5
show the reaction diagram
-
RNA substrate is used
-
-
?
S-adenosyl-L-methionine + G(5')pppAm-mRNA
S-adenosyl-L-homocysteine + G(5')pppm6Am-mRNA
show the reaction diagram
-
poor substrate
-
-
?
S-adenosyl-L-methionine + m7G(5')pppA-mRNA
S-adenosyl-L-homocysteine + m7G(5')pppm6A-mRNA
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + m7G(5')pppAm-mRNA
S-adenosyl-L-homocysteine + m7G(5')pppm6Am-mRNA
show the reaction diagram
S-adenosyl-L-methionine + pppA-mRNA
S-adenosyl-L-homocysteine + pppm6A-mRNA
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
no substrates are the oligonucleotides m7G(5')pppAm, m7G(5')pppA, m7G(5')pppAmpN, no methyl group acceptors are brome mosaic virus RNA, E. coli tRNA and rRNA and yeast tRNA
-
-
?