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2.1.1.64: 3-demethylubiquinol 3-O-methyltransferase

This is an abbreviated version!
For detailed information about 3-demethylubiquinol 3-O-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
3-demethylubiquinol-n
=
S-adenosyl-L-homocysteine
+
ubiquinol-n

Synonyms

2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase, 5-demethylubiquinone-9 methyltransferase, 5-demethylubiquinone-9-methyltransferase, AtCOQ3, COQ3, Coq3 O-methyltransferase, O-methyltransferase, OMHMB methyltransferase, OMHMB-methyltransferase, S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase, UbiG, UbiG methyltransferase, ubiquinone biosynthesis O-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.64 3-demethylubiquinol 3-O-methyltransferase

Systematic Name

Systematic Name on EC 2.1.1.64 - 3-demethylubiquinol 3-O-methyltransferase

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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:3-hydroxy-2-methoxy-5-methyl-6-(all-trans-polyprenyl)-1,4-benzoquinol 3-O-methyltransferase
This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, the human COQ3 enzyme can restore biosynthesis of ubiquinone-6 in coq3 deletion mutants of yeast [3]. The enzymes from yeast, Escherichia coli and rat also catalyse the methylation of 3,4-dihydroxy-5-all-trans-polyprenylbenzoate [3] (a reaction that is classified as EC 2.1.1.114, polyprenyldihydroxybenzoate methyltransferase).