2.1.1.67: thiopurine S-methyltransferase
This is an abbreviated version!
For detailed information about thiopurine S-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.67
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2.1.1.67
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azathioprine
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6-mercaptopurine
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bowel
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pharmacogenetics
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children
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lymphoblastic
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leukemia
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myelosuppression
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erythrocyte
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tpmt*2
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crohn
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thioguanine
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dosing
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s-methylation
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autoimmune
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marrow
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remission
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caucasian
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leukopenia
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myelotoxicity
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ulcerative
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6-methylmercaptopurine
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methotrexate
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ethnic
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inosine
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colitis
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azathioprine-induced
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medicine
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allele-specific
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interindividual
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nudt15
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5-aminosalicylic
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thiopurine-induced
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allopurinol
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pancytopenia
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neutropenia
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dihydropyrimidine
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infliximab
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drug-metabolizing
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pyrophosphohydrolase
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trimodal
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hematotoxicity
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analysis
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nudix
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pemphigus
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diagnostics
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mofetil
- 2.1.1.67
- azathioprine
- 6-mercaptopurine
- bowel
-
pharmacogenetics
- children
- lymphoblastic
- leukemia
-
myelosuppression
- erythrocyte
-
tpmt*2
- crohn
- thioguanine
-
dosing
-
s-methylation
- autoimmune
- marrow
-
remission
-
caucasian
- leukopenia
-
myelotoxicity
-
ulcerative
- 6-methylmercaptopurine
- methotrexate
-
ethnic
- inosine
- colitis
-
azathioprine-induced
- medicine
-
allele-specific
-
interindividual
-
nudt15
-
5-aminosalicylic
-
thiopurine-induced
- allopurinol
- pancytopenia
- neutropenia
- dihydropyrimidine
-
infliximab
-
drug-metabolizing
-
pyrophosphohydrolase
-
trimodal
-
hematotoxicity
- analysis
-
nudix
- pemphigus
- diagnostics
- mofetil
Reaction
Synonyms
6-thiopurine S-methyltransferase, 6-thiopurine transmethylase, mercaptopurine methyltransferase, thiopurine methyl transferase, thiopurine methyltransferase, thiopurine S-methyltransferase, thiopurine-S-methyl-transferase, TMPT, TPMT
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Specific Activity
Specific Activity on EC 2.1.1.67 - thiopurine S-methyltransferase
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0.00000716
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TMPT reference activity after recovery of the bone marrow suppression
0.00003033
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elevated TPMT activity during the recovery phase of a bone marrow suppression, following the pancytopenic period
additional information
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determination of thiopurine S-methyltransferase activity in erythrocytes using 6-thioguanine as substrate and a non-extraction liquid chromatographic technique. This method minimzes sample-handling, reduces inherent imprecision, the possibility of laboratory error and has a potential for further automation
additional information
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activity of TPMT in nmol of the formed 6-mMP/g Hb/h, dialyzed patients, total 30.6, females 30.1, males 31.7, control group, total 28.4, females 28.4, males 28.7
additional information
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median TPMT activities, Singapore Chinese 16.4 U, Singapore Malays 17.8 U, Singapore Indians 16.4 U, one unit of activity is defined as a formation of 1 nmol of 6-methylmercaptopurine per ml of packed red blood cells per h incubation at 37°C
additional information
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normal thiopurine methyltransferase activity, 7.5-14 U/ml erythrocytes
additional information
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thiopurine methyltransferase levels above 23 nmol 6-methylthioguanine/g Hb per h indicates normal enzyme activity
additional information
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TPMT activity amongst 253 healthy Estonian volunteers varies from 21.5 ng/ml/h to 185.5 ng/ml/h with a median of 86.24 ng/ml/h
additional information
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TPMT activity of 0.5% of the patients is low, less than 5 U/ml RBC, for 11.9% intermediate, 5-13.7 U/ml RBC, and for 87.6% high, greater than 13.7 U/ml RBC