2.1.1.74: methylenetetrahydrofolate-tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]
This is an abbreviated version!
For detailed information about methylenetetrahydrofolate-tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing], go to the full flat file.
Word Map on EC 2.1.1.74
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2.1.1.74
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flavin
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m5u54-methyltransferase
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5-methyluridine
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s-adenosyl-l-methionine
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medicine
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methyltransferases
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t-arms
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ribothymidine
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t-loops
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flavin-dependent
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n5,n10-methylenetetrahydrofolate
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ch2thf
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t-stem
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isoalloxazine
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ultrafast
- 2.1.1.74
- flavin
-
m5u54-methyltransferase
- 5-methyluridine
- s-adenosyl-l-methionine
- medicine
- methyltransferases
-
t-arms
- ribothymidine
-
t-loops
-
flavin-dependent
- n5,n10-methylenetetrahydrofolate
-
ch2thf
-
t-stem
- isoalloxazine
-
ultrafast
Reaction
Synonyms
EC 2.1.2.12, FDRTS, folate-dependent ribothymidyl synthase, folate-dependent tRNA methyltransferase, folate/FAD-dependent tRNA T54 methyltransferase, methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase,, TRMFO, tRNA (m5U54)-methyltransferase, tRNA:m5U-54 MTase
ECTree
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Cofactor
Cofactor on EC 2.1.1.74 - methylenetetrahydrofolate-tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]
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FADH2
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using spectroscopic characterization it is shown that TrmFO stabilizes the protonated semiquinone FADH and a catalytic intermediate containing most likely both methylenetetrahydrofolate and an FAD reduced form. TrmFO, in the absence of tRNA, maintains an insulated active site that locks up the methyl donor and protects the reduced forms of the flavin from deleterious oxidative reactions