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2.1.1.79: cyclopropane-fatty-acyl-phospholipid synthase

This is an abbreviated version!
For detailed information about cyclopropane-fatty-acyl-phospholipid synthase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
phospholipid olefinic fatty acid
=
S-adenosyl-L-homocysteine
+
phospholipid cyclopropane fatty acid

Synonyms

C17:cyclopropane synthase, Cfa, CFA synthase, cfaB, CFAS, CPS, CPS1, CPS2, CPS3, cyclopropane fatty acid synthase, cyclopropane fatty acid synthetase, cyclopropane fatty acyl synthase, cyclopropane synthase, cyclopropane-fatty-acyl-phospholipid synthase, HP0416, SfCPA-FAS, synthetase, cyclopropane fatty acid, unsaturated-phospholipid methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.79 cyclopropane-fatty-acyl-phospholipid synthase

Inhibitors

Inhibitors on EC 2.1.1.79 - cyclopropane-fatty-acyl-phospholipid synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(12aS,12bS)-7-fluoro-2,3,5,12,12a,12b-hexahydro-1H,4H-11-oxa-3a,9b-diazabenzo[a]naphtho[2,1,8-cde]azulene
-
-
(1R,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 4-hydroxy-3,5-dimethoxybenzoate
-
-
1,2,5-trimethyl-2,3,4,6-tetrahydro-1H-pyrido[4,3-b]carbazole
-
-
2,5,11-trimethyl-2,3,4,6-tetrahydro-1H-pyrido[4,3-b]carbazole
-
-
3-palmitoyl-2-(9/10-epoxyoleoyl)phosphatidylethanolamine
-
-
3-palmitoyl-2-(9/10-fluorooleoyl)phosphatidyl ethanolamine
-
-
3beta,5alpha-17a-aza-D-homoandrostan-3-ol
-
-
5'-S-[2-(decylamino)ethyl]-5'-thioadenosine
5,5'-dithiobis(2-nitrobenzoic acid)
5,5'-dithiobis-(2-nitrobenzoic acid)
-
substrate does not protect against inactivation
9-methoxy-1,2,5-trimethyl-2,3,4,6-tetrahydro-1H-pyrido[4,3-b]carbazole
-
-
A9145C
Borate
-
competitive
dioctylamine
hexadecyltrimethylammonium bromide
-
-
N,N,N-trimethylhexadecan-1-aminium bromide
-
-
N-Butylmaleimide
-
-
N-decyl-N,N-dimethyldecan-1-aminium bromide
-
-
N-Heptylmaleimide
-
-
N-hexylhexan-1-amine
-
-
N-Hexylmaleimide
-
-
N-octyloctan-1-amine
-
-
N-Pentylmaleimide
-
-
NaCl
Eubacterium HX
-
1 M, 97% inhibition
oleoyl-CoA
-
above 0.05 M
p-hydroxymercuribenzoate
phosphatidylcholine
-
-
S-adenosylhomocysteine
sinefungin
sorbitol monolaurate ester
-
-
sorbitol monooleate ester
-
-
vinylfluorine
-
-
additional information
-
identification of new inhibitors of Escherichia coli cyclopropane fatty acid synthase using a colorimetric assay
-