2.1.1.79: cyclopropane-fatty-acyl-phospholipid synthase
This is an abbreviated version!
For detailed information about cyclopropane-fatty-acyl-phospholipid synthase, go to the full flat file.
Reaction
Synonyms
C17:cyclopropane synthase, Cfa, CFA synthase, cfaB, CFAS, CPS, CPS1, CPS2, CPS3, cyclopropane fatty acid synthase, cyclopropane fatty acid synthetase, cyclopropane fatty acyl synthase, cyclopropane synthase, cyclopropane-fatty-acyl-phospholipid synthase, HP0416, SfCPA-FAS, synthetase, cyclopropane fatty acid, unsaturated-phospholipid methyltransferase
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Inhibitors
Inhibitors on EC 2.1.1.79 - cyclopropane-fatty-acyl-phospholipid synthase
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(12aS,12bS)-7-fluoro-2,3,5,12,12a,12b-hexahydro-1H,4H-11-oxa-3a,9b-diazabenzo[a]naphtho[2,1,8-cde]azulene
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(1R,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 4-hydroxy-3,5-dimethoxybenzoate
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5,5'-dithiobis-(2-nitrobenzoic acid)
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substrate does not protect against inactivation
additional information
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identification of new inhibitors of Escherichia coli cyclopropane fatty acid synthase using a colorimetric assay
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5'-S-[2-(decylamino)ethyl]-5'-thioadenosine
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this compound is also found to completely inhibit cyclopropanation of the phospholipids in growing Escherichia coli cells in vivo, at 0.15 mM
5,5'-dithiobis(2-nitrobenzoic acid)
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reversed by addition of dithiothreitol