2.1.1.79: cyclopropane-fatty-acyl-phospholipid synthase
This is an abbreviated version!
For detailed information about cyclopropane-fatty-acyl-phospholipid synthase, go to the full flat file.
Reaction
Synonyms
C17:cyclopropane synthase, Cfa, CFA synthase, cfaB, CFAS, CPS, CPS1, CPS2, CPS3, cyclopropane fatty acid synthase, cyclopropane fatty acid synthetase, cyclopropane fatty acyl synthase, cyclopropane synthase, cyclopropane-fatty-acyl-phospholipid synthase, HP0416, SfCPA-FAS, synthetase, cyclopropane fatty acid, unsaturated-phospholipid methyltransferase
ECTree
2.1.1.79 cyclopropane-fatty-acyl-phospholipid synthaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.1.1.79 - cyclopropane-fatty-acyl-phospholipid synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 1-stearoyl-2-oleoyl-sn-glycero-3-[phospho-rac-(1-glycerol)]
S-adenosyl-L-homocysteine + 1-stearoyl-2-dihydrosterculoyl-sn-glycero-3-[phospho-rac-(1-glycerol)]
-
reaction takes place via methyl transfer followed by proton loss, rather than by processes that are initiated by proton abstraction from S-adenosyl-L-methionine. Methyl transfer takes place via a tight SN2 transition state
-
-
?
S-adenosyl-L-methionine + cardiolipin
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidylcholine
?
-
the enzyme acts primarily on the sn-1 position of + phosphatidylcholine
-
-
?
S-adenosyl-L-methionine + phosphatidylglycerol
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
S-adenosyl-L-methionine + phospholipids
S-adenosyl-L-homocysteine + phospholipid + cyclopropane fatty acid
-
-
-
-
?
S-adenosyl-L-methionine + plasmenylethanolamine
S-adenosyl-L-homocysteine + plasmenylethanolamine cyclopropane fatty acid
Se-adenosyl-L-selenomethionine + 1-stearoyl-2-oleoyl-sn-glycero-3-[phospho-rac-(1-glycerol)]
Se-adenosyl-L-selenohomocysteine + 1-stearoyl-2-dihydrosterculoyl-sn-glycero-3-[phospho-rac-(1-glycerol)]
-
-
-
-
?
Te-adenosyl-L-telluromethionine + 1-stearoyl-2-oleoyl-sn-glycero-3-[phospho-rac-(1-glycerol)]
Te-adenosyl-L-tellurohomocysteine + 1-stearoyl-2-dihydrosterculoyl-sn-glycero-3-[phospho-rac-(1-glycerol)]
-
-
-
-
?
S-adenosyl-L-homocysteine + phosphatidylcholine
S-adenosyl-L-homocysteine + ?
-
phosphatidylcholine is not a substrate
-
-
?
S-adenosyl-L-homocysteine + phosphatidylcholine
S-adenosyl-L-homocysteine + ?
-
addition of the methylene group to oleic acid occurs at the sn-1 position
-
-
?
S-adenosyl-L-methionine + oleate
S-adenosyl-L-homocysteine + dihydrosterculate
-
-
-
?
S-adenosyl-L-methionine + oleate
S-adenosyl-L-homocysteine + dihydrosterculate
-
-
-
?
S-adenosyl-L-methionine + oleic acid
S-adenosyl-L-homocysteine + dihydrosterculic acid
-
-
-
-
?
S-adenosyl-L-methionine + oleic acid
S-adenosyl-L-homocysteine + dihydrosterculic acid
Limosilactobacillus reuteri ATCC PTA 6475
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + ?
-
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
phosphatidylethanolamine which contains cyclopropane fatty acids
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
no exchange of the cylopropane methylene protons with the solvent during catalysis. There is a significant intermolecular primary tritium kinetic isotope effect consistent with a partially rate determining deprotonation step
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
reaction is not affected by the order-disorder state of the lipid substrate
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
increased level of cyclopropane fatty acid synthase activity as bacterial cultures enter stationary phase is transient, activity quickly declines to the basal level, the loss of activity is due to proteolytic degradation dependent on expression of the heat shock regulon
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
methylation of unsaturated fatty acid moieties of phospholipids in the phospholipid bilayer
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
the enzyme acts on sn-2 of phospholipids
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
Escherichia coli B / ATCC 11303
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
Eubacterium HX
-
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
Lacticaseibacillus casei ATCC 334
-
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
S-adenosylmethionine levels in conjugation with cyclopropane fatty acid synthase activities regulates cyclopropane fatty acid synthesis in Lactobacillus plantarum
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
the cfa locus is an essential component of the acid stress response of Lactococcus lactis MG1363
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
the cfa locus is an essential component of the acid stress response of Lactococcus lactis MG1363
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
increase in expression of CFA synthase at early stationary phase is due to the alternative sigma factor RpoS
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
Serratia marcescens contains endogenous lipid substrates which cannot be removed or replaced by simple manipulations
phosphatidylethanolamine which contains cyclopropane fatty acids
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
-
-
-
?
S-adenosyl-L-methionine + phospholipid olefinic fatty acid
S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
-
addition of a methylene group from S-adenosylmethionine to the cis-double bond of monoenoic phospholipid-bound fatty acids
-
-
?
S-adenosyl-L-methionine + plasmenylethanolamine
S-adenosyl-L-homocysteine + plasmenylethanolamine cyclopropane fatty acid
-
-
-
-
?
S-adenosyl-L-methionine + plasmenylethanolamine
S-adenosyl-L-homocysteine + plasmenylethanolamine cyclopropane fatty acid
-
-
-
-
?
S-adenosyl-L-methionine + vaccenic acid
S-adenosyl-L-homocysteine + lactobacillic acid
-
-
-
-
?
S-adenosyl-L-methionine + vaccenic acid
S-adenosyl-L-homocysteine + lactobacillic acid
Limosilactobacillus reuteri ATCC PTA 6475
-
-
-
-
?
additional information
?
-
-
growth conditions that result in an increase in the relative amount of C17:cyclopropane fatty acid yield better survival after lyophilization
-
-
?
additional information
?
-
-
growth conditions that result in an increase in the relative amount of C17:cyclopropane fatty acid yield better survival after lyophilization
-
-
?
additional information
?
-
-
cyclopropanation occurs in the sn-1 and sn-2 positions in lipids, cyclopropanation of phosphatidylcholines and sulfoquinovosyldiacylglycerols occurs more extensively with acidity than with phosphate starvation
-
-
?
additional information
?
-
-
cyclopropanation occurs in the sn-1 and sn-2 positions in lipids, cyclopropanation of phosphatidylcholines and sulfoquinovosyldiacylglycerols occurs more extensively with acidity than with phosphate starvation
-
-
?
