2.1.1.8: histamine N-methyltransferase

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For detailed information about histamine N-methyltransferase, go to the full flat file.

Reaction

Synonyms

histamine 1-methyltransferase, histamine methyltransferase, histamine N-methyltransferase, histamine-methylating enzyme, histamine-N-methyltransferase, HMT, HNMT, imidazole methyltransferase, imidazole N-methyltransferase, imidazolemethyltransferase, methyltransferase, histamine, Ntau-methyltransferase, S-adenosylmethionine-histamine N-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.8 histamine N-methyltransferase

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Results	in table
8	Activating Compound
280	AA Sequence
10	Application
1	CAS Registry Number
6	Cloned(Commentary)
1	Crystallization (Commentary)
299	Disease/ Diagnostics
1	Expression
1	General Information
1	General Stability
114	Inhibitors
7	Ki Value [mM]
29	KM Value [mM]
5	Localization
11	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
66	Organism
3	Pathway
12	PDB ID
15	pH Optimum
2	pH Range
17	Protein Variants
16	Purification (Commentary)
5	Reaction
2	Reaction Type
66	Reference
138	Source Tissue
21	Specific Activity [micromol/min/mg]
5	Storage Stability
51	Substrates and Products (Substrate)
13	Subunits
37	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
7	Temperature Stability [°C]
4	Turnover Number [1/s]

KI Value

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KI Value on EC 2.1.1.8 - histamine N-methyltransferase

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00005

Amodiaquin

Rattus norvegicus

-

-

441572

0.0000186

amodiaquine

Homo sapiens

P50135

-

675356

0.0007

d-Chlorpheniramine

Rattus norvegicus

-

-

441572

0.008

Dimaprit

Rattus norvegicus

-

-

441572

0.000091

Metoprine

Homo sapiens

P50135

-

675356

0.001

SKF 91488

Rattus norvegicus

-

-

441572

0.0000382

tacrine

Homo sapiens

P50135

-

675356