2.1.1.98: diphthine synthase

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For detailed information about diphthine synthase, go to the full flat file.

Word Map on EC 2.1.1.98

2.1.1.98

diphthamide

toxin

pyrococcus

horikoshii

trimethylation

diphtheria

eef2

ill-defined

eukaryal

amidase

Reaction

3 S-adenosyl-L-methionine +

2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2]

= 3 S-adenosyl-L-homocysteine +

diphthine-[translation elongation factor 2]

Synonyms

diphthine methyltransferase, diphthine synthase, Dph5, methyltransferase, diphthine, S-adenosyl-L-methionine:elongation factor 2 methyltransferase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.98 diphthine synthase

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Results	in table
2266	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
2	Crystallization (Commentary)
2	Expression
4	General Information
3	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
81	Organism
1	Pathway
166	PDB ID
2	Purification (Commentary)
4	Reaction
1	Reaction Type
10	Reference
17	Substrates and Products (Substrate)
6	Subunits
14	Synonyms
1	Systematic Name

Expression

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Expression on EC 2.1.1.98 - diphthine synthase

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dph7 mutants show drastically upregulated interaction between the enzyme and eukaryal translation elongation factor 2, indicating that their association is kept in check by Dph7

2 entries