2.1.1.98: diphthine synthase

This is an abbreviated version!
For detailed information about diphthine synthase, go to the full flat file.

Reaction

3 S-adenosyl-L-methionine +

Synonyms

diphthine methyltransferase, diphthine synthase, Dph5, methyltransferase, diphthine, S-adenosyl-L-methionine:elongation factor 2 methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.98 diphthine synthase

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Results	in table
2266	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
2	Crystallization (Commentary)
2	Expression
4	General Information
3	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
81	Organism
1	Pathway
166	PDB ID
2	Purification (Commentary)
4	Reaction
1	Reaction Type
10	Reference
17	Substrates and Products (Substrate)
6	Subunits
14	Synonyms
1	Systematic Name

Reaction

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Reaction on EC 2.1.1.98 - diphthine synthase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

3 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] = 3 S-adenosyl-L-homocysteine + diphthine-[translation elongation factor 2]

overall reaction

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S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidine-[translation elongation factor 2] = S-adenosyl-L-homocysteine + diphthine-[translation elongation factor 2]

(1c)

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S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidine-[translation elongation factor 2] = S-adenosyl-L-homocysteine + 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidine-[translation elongation factor 2]

(1b)

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S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] = S-adenosyl-L-homocysteine + 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidine-[translation elongation factor 2]

(1a)

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