2.1.1.B75: flavonoid 7-O-methyltransferase

This is an abbreviated version!
For detailed information about flavonoid 7-O-methyltransferase, go to the full flat file.

Reaction

Synonyms

7-O-methyltransferase, CGZ69_28180, flavonoid O-methyltransferase, OMT2, POMT7, SaOMT, SaOMT-2, SAVERM_2382, SpOMT7740

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.B75 flavonoid 7-O-methyltransferase

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Results	in table
2	AA Sequence
4	Application
4	Cloned(Commentary)
2	Cofactor
4	General Information
6	Inhibitors
4	kcat/KM [mM/s]
4	KM Value [mM]
2	Metals/Ions
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
10	Organism
2	pH Optimum
3	Protein Variants
2	Purification (Commentary)
1	Reaction
8	Reference
35	Substrates and Products (Substrate)
2	Subunits
14	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
4	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.1.1.B75 - flavonoid 7-O-methyltransferase

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2 S-adenosyl-L-methionine + aloe emodin

2 S-adenosyl-L-homocysteine + O-methylaloe emodin

Streptomyces peucetius subsp. caesius

A0A1B1W6Z7

755826

2 S-adenosyl-L-methionine + beta-sitosterol

2 S-adenosyl-L-homocysteine + O-methyl-beta-sitosterol

Streptomyces peucetius subsp. caesius

A0A1B1W6Z7

755826

2 S-adenosyl-L-methionine + daunorubicin

2 S-adenosyl-L-homocysteine + O-methyldaunorubicin

Streptomyces peucetius subsp. caesius

A0A1B1W6Z7

755826

2 S-adenosyl-L-methionine + emodin

2 S-adenosyl-L-homocysteine + O-methylemodin

Streptomyces peucetius subsp. caesius

A0A1B1W6Z7

755826

2 S-adenosyl-L-methionine + genistein

2 S-adenosyl-L-homocysteine + O-methylgenistein + O,O'-dimethylgenistein + O,O',O''-trimethylgenistein

Streptomyces peucetius subsp. caesius

A0A1B1W6Z7

755826

2 S-adenosyl-L-methionine + kaempferol

2 S-adenosyl-L-homocysteine + 3,7-O-dimethylkaempferol

Populus sp.

activity only of enzyme mutant POMT7-M1, D257G, not of wild-type POMT7

713037

2 S-adenosyl-L-methionine + luteolin

2 S-adenosyl-L-homocysteine + methoxyluteolin

Streptomyces peucetius subsp. caesius

A0A1B1W6Z7

755826

2 S-adenosyl-L-methionine + phloretin

2 S-adenosyl-L-homocysteine + methoxyphloretin

Streptomyces peucetius subsp. caesius

A0A1B1W6Z7

755826

2 S-adenosyl-L-methionine + quercetin

2 S-adenosyl-L-homocysteine + 3,7-O-dimethylquercetin

Populus sp.

activity only of enzyme mutant POMT7-M1, D257G, not of wild-type POMT7, molecular docking of quercetin into the modeled structure of Asp257Gly

713037

S-adenosyl-L-methionine + (2S)-5,7,4'-trihydroxyflavanone

S-adenosyl-L-homocysteine + (2S)-5,4'-dihydroxy-7-methoxyflavanone

2 entries

S-adenosyl-L-methionine + (2S)-naringenin

S-adenosyl-L-homocysteine + (2S)-sakuranetin

2 entries

S-adenosyl-L-methionine + 3,3',4',5,7-pentahydroxyflavone

S-adenosyl-L-homocysteine + 3,3',4',5-tetrahydroxy-7-methoxyflavone

2 entries

S-adenosyl-L-methionine + 3,4',5,7-tetrahydroxyflavanone

S-adenosyl-L-homocysteine + 3,4',5-trihydroxy-7-methoxyflavanone

Streptomyces avermitilis

i.e. kaempferol, active is identical to that with (2S)-naringenin (i.e. (2S)-5,7,4'-trihydroxyflavanone)

674128

S-adenosyl-L-methionine + 3,5,7,4'-tetrahydroxy-3'-methoxyflavone

S-adenosyl-L-homocysteine + 3,5,4'-trihydroxy-7,3'-dimethoxyflavone

2 entries

S-adenosyl-L-methionine + 3-hydroxyflavone

S-adenosyl-L-homocysteine + 3-methoxyflavone

Streptomyces peucetius subsp. caesius

A0A1B1W6Z7

755826

S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone

S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone

2 entries

S-adenosyl-L-methionine + 5,7,4'-trihydroxyisoflavone

S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyisoflavone

Streptomyces avermitilis

i.e. genistein. 59% of the activity with (2S)-naringenin (i.e. (2S)-5,7,4'-trihydroxyflavanone)

674128

S-adenosyl-L-methionine + 7,4'-dihydroxyisoflavone

S-adenosyl-L-homocysteine + 4'-hydroxy-7-methoxyisoflavone

2 entries

S-adenosyl-L-methionine + 7,8-dihydroxyflavone

S-adenosyl-L-homocysteine + 7-hydroxy-8-methoxyflavone

Streptomyces peucetius subsp. caesius

A0A1B1W6Z7

755826

S-adenosyl-L-methionine + apigenin

S-adenosyl-L-homocysteine + genkwanin + 5-hydroxy-7,4'-dimethoxyflavone

2 entries

S-adenosyl-L-methionine + dihydrokaempferol

S-adenosyl-L-homocysteine + 7-O-methylaromadendrin

2 entries

S-adenosyl-L-methionine + kaempferol

S-adenosyl-L-homocysteine + 7-O-methylkaempferol

Populus sp.

713037

S-adenosyl-L-methionine + naringenin

S-adenosyl-L-homocysteine + sakuranetin + 5-hydroxy-7,4'-dimethoxyflavanone + 4'-hydroxy-5,7-dimethoxyflavanone

2 entries

S-adenosyl-L-methionine + quercetin

S-adenosyl-L-homocysteine + 7-O-methylquercetin

Populus sp.

713037

S-adenosyl-L-methionine + resveratrol

S-adenosyl-L-homocysteine + desoxyrhapontigenin + 5-hydroxy-3,4'-dimethoxystilbene

2 entries