2.1.2.1: glycine hydroxymethyltransferase

This is an abbreviated version!
For detailed information about glycine hydroxymethyltransferase, go to the full flat file.

Word Map on EC 2.1.2.1

2.1.2.1

one-carbon

pyridoxal

thymidylate

purine

5'-phosphate

homocysteine

dihydrofolate

folate-dependent

photorespiratory

photorespiration

folate-mediated

pyridoxal-5'-phosphate

thf

dtmp

mthfd1

plp-dependent

remethylation

aldimine

phgdh

medicine

folate-metabolizing

5,10-methenyltetrahydrofolate

5'-phosphate-dependent

antifolate

hydroxypyruvate

quinonoid

5-methyltetrahydrofolate

glycerate

5-formyltetrahydrofolate

drug development

folate-related

d-alanine

c1-tetrahydrofolate

1-carbon

5-formyl

polyglutamate

l-threonine

alpha-protons

slc19a1

retro-aldol

degradation

analysis

synthesis

biotechnology

pharmacology

Reaction

Synonyms

AtSHMT3, bsSHMT, bstSHMT, EC 4.1.2.6, eSHMT, GlyA, GlyA protein, glycine hydroxymethyltransferrase, hSHMT, L-serine hydroxymethyltransferase, mitochondrial serine hydroxymethyltransferase, MJ1597, PvSHMT, Rhg4, serine hydroxymethyl transferase, serine hydroxymethylase hydroxymethyltransferase, serine, serine hydroxymethyltransferase, serine hydroxymethyltransferase 1, serine hydroxymethyltransferase 2, serine hydroxymethyltransferase 2alpha, serine transhydroxymethylase, serine:H4F hydroxymethyltransferase, serine:tetrahydrofolate hydroxymethyltransferase, SHM1, SHM2, SHMT, SHMT-1, SHMT-L, SHMT-S, SHMT08, SHMT1, SHMT2, SHMT2alpha, SHMT3, zcSHMT, zebrafish cytosolic serine hydroxymethyltransferase, zebrafish mitochondiral serine hydroxymethyltransferase, zmSHMT

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.2 Hydroxymethyl-, formyl- and related transferases

2.1.2.1 glycine hydroxymethyltransferase

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Results	in table
12	Activating Compound
57530	AA Sequence
55	Application
1	CAS Registry Number
84	Cloned(Commentary)
203	Cofactor
22	Crystallization (Commentary)
984	Disease/ Diagnostics
8	Expression
107	General Information
24	General Stability
26	IC50 Value
314	Inhibitors
50	kcat/KM [mM/s]
33	Ki Value [mM]
179	KM Value [mM]
129	Localization
20	Metals/Ions
102	Molecular Weight [Da]
191	Natural Substrates/ Products (Substrates)
571	Organism
28	Pathway
280	PDB ID
44	pH Optimum
16	pH Range
14	pH Stability
1	pI Value
6	Posttranslational Modification
92	Protein Variants
71	Purification (Commentary)
50	Reaction
1	Reaction Type
241	Reference
2	Renatured (Commentary)
95	Source Tissue
69	Specific Activity [micromol/min/mg]
13	Storage Stability
498	Substrates and Products (Substrate)
137	Subunits
345	Synonyms
1	Systematic Name
29	Temperature Optimum [°C]
17	Temperature Range [°C]
49	Temperature Stability [°C]
111	Turnover Number [1/s]

KI Value

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KI Value on EC 2.1.2.1 - glycine hydroxymethyltransferase

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1.3

2-aminoalanine

Euglena gracilis

441409

5,10-methenyltetrahydrofolate

Glycine max

441407

2.9

5,10-methylene-5,6,7,8-tetrahydrofolic acid

Glycine max

441407

1.8

5-methyl-5,6,7,8-tetrahydrofolate

Glycine max

441407

13 - 23

aminoisobutyrate

Oryctolagus cuniculus

441400

0.014

carboxymethoxylamine

Spinacia oleracea

441391

40 - 55

D-alanine

Oryctolagus cuniculus

441400

2.02

D-cycloserine

Vigna radiata

441408

3.9 - 11.2

DL-2-methylserine

2 entries

2.7

DL-allothreonine

Oryctolagus cuniculus

441400

2.3 - 6.8

glycine

4 entries

0.3

L-cysteine

Euglena gracilis

441409

0.368 - 2.8

L-serine

4 entries

L-threonine

Oryctolagus cuniculus

441400

0.023

lometrexol

Homo sapiens

at pH 7.2 and 30°C

756477

0.201

methotrexate

Homo sapiens

at pH 7.2 and 30°C

756477

nolatrexed

Homo sapiens

Ki above 1 mM, at pH 7.2 and 30°C

756477

0.122

raltitrexed

Homo sapiens

at pH 7.2 and 30°C

756477

0.14 - 0.27

tetrahydrofolate

4 entries

0.085

tetrahydropteroylglutamate

Arabidopsis thaliana

Q94JQ3

pH 8.5, temperature not specified in the publication, recombinant AtSHMT3

718775

additional information

3 entries