2.1.2.1: glycine hydroxymethyltransferase

This is an abbreviated version!
For detailed information about glycine hydroxymethyltransferase, go to the full flat file.

Reaction

Synonyms

AtSHMT3, bsSHMT, bstSHMT, EC 4.1.2.6, eSHMT, GlyA, GlyA protein, glycine hydroxymethyltransferrase, hSHMT, L-serine hydroxymethyltransferase, mitochondrial serine hydroxymethyltransferase, MJ1597, PvSHMT, Rhg4, serine hydroxymethyl transferase, serine hydroxymethylase hydroxymethyltransferase, serine, serine hydroxymethyltransferase, serine hydroxymethyltransferase 1, serine hydroxymethyltransferase 2, serine hydroxymethyltransferase 2alpha, serine transhydroxymethylase, serine:H4F hydroxymethyltransferase, serine:tetrahydrofolate hydroxymethyltransferase, SHM1, SHM2, SHMT, SHMT-1, SHMT-L, SHMT-S, SHMT08, SHMT1, SHMT2, SHMT2alpha, SHMT3, zcSHMT, zebrafish cytosolic serine hydroxymethyltransferase, zebrafish mitochondiral serine hydroxymethyltransferase, zmSHMT

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.2 Hydroxymethyl-, formyl- and related transferases

                2.1.2.1 glycine hydroxymethyltransferase

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Results	in table
12	Activating Compound
57530	AA Sequence
55	Application
1	CAS Registry Number
84	Cloned(Commentary)
203	Cofactor
22	Crystallization (Commentary)
984	Disease/ Diagnostics
8	Expression
107	General Information
24	General Stability
26	IC50 Value
314	Inhibitors
50	kcat/KM [mM/s]
33	Ki Value [mM]
179	KM Value [mM]
129	Localization
20	Metals/Ions
102	Molecular Weight [Da]
191	Natural Substrates/ Products (Substrates)
571	Organism
28	Pathway
280	PDB ID
44	pH Optimum
16	pH Range
14	pH Stability
1	pI Value
6	Posttranslational Modification
92	Protein Variants
71	Purification (Commentary)
50	Reaction
1	Reaction Type
241	Reference
2	Renatured (Commentary)
95	Source Tissue
69	Specific Activity [micromol/min/mg]
13	Storage Stability
498	Substrates and Products (Substrate)
137	Subunits
345	Synonyms
1	Systematic Name
29	Temperature Optimum [°C]
17	Temperature Range [°C]
49	Temperature Stability [°C]
111	Turnover Number [1/s]

Organism

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of the Enzyme Summary Page.

Organism on EC 2.1.2.1 - glycine hydroxymethyltransferase

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Aedes aegypti

-

757905

-

-

brenda

Aedes aegypti NIH Rockefeller

-

757905

-

-

brenda

Aeropyrum pernix

-

660469

-

-

brenda

Alcanivorax sp.

gene glyA

736645

-

-

brenda

Aphanothece halophytica

2 entries

Aquifex aeolicus

-

660469

-

-

brenda

Arabidopsis thaliana

3 entries

Arabidopsis thaliana C24

C24

660180

-

-

brenda

Archaeoglobus fulgidus

-

660469

-

-

brenda

Arthrobacter sp.

gene glyA

735436

-

-

brenda

Arthrobacter sp. MCCC 1A05493

gene glyA

735436

-

-

brenda

Bacillus subtilis

-

660460, 704347, 718968, 718984

-

-

brenda

Bombyx mori

-

755905

-

-

brenda

Bombyx mori p50T

-

755905

-

-

brenda

Bos taurus

-

441417, 441420

-

-

brenda

Burkholderia cenocepacia

gene glyA

737188

B4ECY9

UniProt

brenda

Burkholderia pseudomallei

gene glyA

737188

A0A069BAT4

UniProt

brenda

Burkholderia pseudomallei ATCC 23343

gene glyA

737188

A0A069BAT4

UniProt

brenda

Caenorhabditis briggsae

-

441438

-

-

brenda

Caenorhabditis elegans

-

441438

-

-

brenda

Campylobacter jejuni

gene glyA

737188

Q9S6K1

UniProt

brenda

Campylobacter jejuni ATCC 33560

gene glyA

737188

Q9S6K1

UniProt

brenda

Corynebacterium glutamicum

2 entries

Corynebacterium glutamicum ATCC 13032

strain ATCC13032

704756

-

-

brenda

Cricetulus griseus

-

441420, 441434

-

-

brenda

Danio rerio

2 entries

Danio rerio AB

AB strain

676954

Q2TL58

SwissProt

brenda

Eremothecium gossypii

-

657809

Q75BQ6

SwissProt

brenda

Escherichia coli

6 entries

Escherichia coli AB90054

-

673397

-

-

brenda

Escherichia coli K-12 MG1655

-

718557

-

-

brenda

Euglena gracilis

-

441409, 441437

-

-

brenda

Euglena gracilis Z

-

441409, 441437

-

-

brenda

Geobacillus stearothermophilus

5 entries

Glutamicibacter nicotianae

-

756288

U5TRK6

UniProt

brenda

Glycine max

2 entries

Glycine max L. Merr. cv. Williams

soybean

441407

-

-

brenda

Helicobacter pylori

-

758178

P56089

UniProt

brenda

Helicobacter pylori 26695

-

758178

P56089

UniProt

brenda

Homo sapiens

15 entries

Hordeum vulgare

-

718775

-

-

brenda

Hordeum vulgare Bob

-

718775

-

-

brenda

Hydrogenobacter thermophilus

gene HTH1832

719472

-

-

brenda

Hydrogenobacter thermophilus TK-6 / IAM 12695

gene HTH1832

719472

-

-

brenda

Hyphomicrobium methylovorum

2 entries

Idiomarina loihiensis

-

756948

-

-

brenda

Komagataella pastoris

-

755964

F2QZA4

UniProt

brenda

Komagataella pastoris X-33

-

755964

F2QZA4

UniProt

brenda

Leishmania donovani

-

676982

Q86LS9

SwissProt

brenda

Leishmania donovani MHOM/IN/80/Dd8

-

676982

Q86LS9

SwissProt

brenda

Leishmania infantum

-

675874

-

-

brenda

Leishmania major

-

675874

-

-

brenda

Macaca radiata

Bonnet monkey

441403, 441404

-

-

brenda

Medicago truncatula

-

756837

G7ILW0

UniProt

brenda

Methanocaldococcus jannaschii

2 entries

Methanocaldococcus jannaschii DSM 2661

-

730918

Q58992

SwissProt

brenda

Methanolobus tindarius

-

727262

-

-

brenda

Methanosarcina barkeri

-

726831, 727262

Q46A52

SwissProt

brenda

Methanosarcina barkeri DSM 804

-

726831, 727262

Q46A52

SwissProt

brenda

Methanospirillum hungatei

-

727262

-

-

brenda

Methanospirillum hungatei GP1

-

727262

-

-

brenda

Methanothermobacter marburgensis

-

660469

-

-

brenda

Methanothermobacter thermautotrophicus

-

660469

-

-

brenda

Methanothrix soehngenii

-

727262

-

-

brenda

Mus musculus

-

441405, 704060, 704435

-

-

brenda

Mycobacterium tuberculosis

2 entries

Mycobacterium tuberculosis H37Rv

2 entries

Neurospora crassa

-

441420, 441434

-

-

brenda

Oryctolagus cuniculus

5 entries

Oryza sativa Japonica Group

cultivar Zhonghua 11

757362

-

-

brenda

Ovis aries

-

441393, 441416, 441420, 441425, 441426, 441427, 441428, 441429, 441430, 441434, 657811, 658892, 659572, 719472

-

-

brenda

Pisum sativum

2 entries

Pisum sativum Progress 9

-

718775

-

-

brenda

Plasmodium berghei

-

757384

-

-

brenda

Plasmodium falciparum

3 entries

Plasmodium falciparum TM4

strainTM4

705602

-

-

brenda

Plasmodium vivax

5 entries

Plasmodium vivax Salvador I

-

757384

A5K8L9

UniProt

brenda

Pseudomonas plecoglossicida

gene glyA

737301

L7Y8B0

UniProt

brenda

Pseudomonas plecoglossicida MCCC 1K00022

gene glyA

737301

L7Y8B0

UniProt

brenda

Psychromonas ingrahamii

2 entries

Psychromonas ingrahamii 37

gene glyA

736646, 737188

A1SUU0

UniProt

brenda

Pyrococcus abyssi

-

660469

-

-

brenda

Pyrococcus horikoshii

-

660469

-

-

brenda

Rattus norvegicus

2 entries

Rattus norvegicus Wistar

Wistar strain

441399

-

-

brenda

Rickettsia rickettsii

gene glyA

737188

A8GTI9

UniProt

brenda

Rickettsia rickettsii Sheila Smith

gene glyA

737188

A8GTI9

UniProt

brenda

Saccharolobus solfataricus

2 entries

Saccharolobus solfataricus P2

-

441422

Q9UWT5

UniProt

brenda

Saccharomyces cerevisiae

-

441413, 441420, 441427, 756534

-

-

brenda

Saccharomyces cerevisiae 3701B

-

441413

-

-

brenda

Saccharomyces cerevisiae BY4741

-

756534

-

-

brenda

Salmonella enterica subsp. enterica serovar Typhimurium

2 entries

Shewanella algae

gene glyA

736753

R9YJZ9

UniProt

brenda

Simkania negevensis

strain ATCC VR1471

675480

Q49K94

SwissProt

brenda

Solanum tuberosum

cv. Solara, antisense lines G310-10, G310-16, G310-76, G310-101 and G310-106

676503

-

-

brenda

Spinacia oleracea

-

441391

-

-

brenda

Staphylococcus aureus

gene glyA

737188

Q5HE87

UniProt

brenda

Staphylococcus aureus COL

gene glyA

737188

Q5HE87

UniProt

brenda

Streptococcus thermophilus

-

755784

Q5M0B4

UniProt

brenda

Streptococcus thermophilus CNRZ 1066

-

755784

Q5M0B4

UniProt

brenda

Synechocystis sp.

strain PCC 6803

676615

-

-

brenda

Thermotoga maritima

-

660469

-

-

brenda

Thermus thermophilus

gene glyA

737188

Q5SI56

UniProt

brenda

Trichomonas vaginalis

strains T1 and G3

673412

-

-

brenda

Vigna radiata

2 entries

Waddlia chondrophila

strain ATCC 1470

675480

Q49KA1

SwissProt

brenda

Aphanothece halophytica

-

719529

I7H6W6

UniProt

brenda

Aphanothece halophytica

-

755912

-

-

brenda

Arabidopsis thaliana

-

662384, 700740, 720740

-

-

brenda

Arabidopsis thaliana

C24

660180

-

-

brenda

Arabidopsis thaliana

ecotype Columbia

718775

Q94JQ3

UniProt

brenda

Corynebacterium glutamicum

strain ATCC 13032

671499

-

-

brenda

Corynebacterium glutamicum

strain ATCC13032

704756

-

-

brenda

Danio rerio

-

686353

A9LDD9, Q7SXN1

UniProt

brenda

Danio rerio

AB strain

676954

Q2TL58

SwissProt

brenda

Escherichia coli

-

441412, 441418

-

-

brenda

Escherichia coli

-

441424

P0A825

Uniprot

brenda

Escherichia coli

-

441427, 441433, 441434, 659237, 659754, 673397, 685708

-

-

brenda

Escherichia coli

-

703634, 703674

P0A825

Uniprot

brenda

Escherichia coli

-

704060, 718557, 718984

-

-

brenda

Escherichia coli

gene glyA

736646, 737188

P0A825

Uniprot

brenda

Geobacillus stearothermophilus

-

441390, 441431, 441432, 658127, 660460

-

-

brenda

Geobacillus stearothermophilus

-

702126

Q7SIB6

Uniprot

brenda

Geobacillus stearothermophilus

-

703629, 704060, 718968, 719472

-

-

brenda

Geobacillus stearothermophilus

-

758412

Q7SIB6

Uniprot

brenda

Geobacillus stearothermophilus

gene glyA

737188

Q7SIB6

Uniprot

brenda

Glycine max

cultivar Williams 82

758045

-

-

brenda

Glycine max

soybean

441407

-

-

brenda

Homo sapiens

-

441421, 441427, 441434, 441435, 441436, 659572, 659754, 671589, 674506

-

-

brenda

Homo sapiens

-

674993

P34896

Uniprot

brenda

Homo sapiens

-

703863, 704060, 704565, 704566, 720054

-

-

brenda

Homo sapiens

-

736084

P34896

Uniprot

brenda

Homo sapiens

-

736727, 736882

P34897

UniProt

brenda

Homo sapiens

-

736925, 755894

-

-

brenda

Homo sapiens

-

756058

P34896

Uniprot

brenda

Homo sapiens

-

756058

P34897

UniProt

brenda

Homo sapiens

-

756098

P34896

Uniprot

brenda

Homo sapiens

-

756098

P34897

UniProt

brenda

Homo sapiens

-

756477

-

-

brenda

Homo sapiens

-

756695

P34896

Uniprot

brenda

Homo sapiens

-

756695

P34897

UniProt

brenda

Homo sapiens

-

756705

P34896

Uniprot

brenda

Homo sapiens

-

756725

P34897

UniProt

brenda

Hyphomicrobium methylovorum

-

441411

-

-

brenda

Hyphomicrobium methylovorum

strain GM2, a glycine resistant mutant derived from strain KM146

441410

-

-

brenda

Methanocaldococcus jannaschii

-

659269, 660469

-

-

brenda

Methanocaldococcus jannaschii

-

730918

Q58992

SwissProt

brenda

Mycobacterium tuberculosis

-

659265

P9WGI7, P9WGI9

SwissProt

brenda

Mycobacterium tuberculosis

gene glyA1

737188

P9WGI9

SwissProt

brenda

Mycobacterium tuberculosis H37Rv

-

659265

P9WGI7, P9WGI9

SwissProt

brenda

Mycobacterium tuberculosis H37Rv

gene glyA1

737188

P9WGI9

SwissProt

brenda

Oryctolagus cuniculus

-

441394, 441400, 441401, 441402, 441415, 441418, 441419, 441420, 441423, 441427, 441434

-

-

brenda

Oryctolagus cuniculus

-

658083

P07511

Uniprot

brenda

Oryctolagus cuniculus

-

659226

-

-

brenda

Oryctolagus cuniculus

-

671589

P07511

Uniprot

brenda

Oryctolagus cuniculus

-

704060, 719472

-

-

brenda

Pisum sativum

-

441427, 441434, 718775

-

-

brenda

Pisum sativum

pea

391984

-

-

brenda

Plasmodium falciparum

-

674993, 705603, 736084, 757384

-

-

brenda

Plasmodium falciparum

one enzymatically functional SHMT isozyme, PfSHMTc, and one related, apparently inactive isoform, PfSHMTm, encoded by different genes pfshmt and PF14_ 0534, respectively

720362

-

-

brenda

Plasmodium falciparum

strainTM4

705602

-

-

brenda

Plasmodium vivax

-

703653

-

-

brenda

Plasmodium vivax

-

735367

A5K8L9

UniProt

brenda

Plasmodium vivax

-

736084, 736499, 755894

-

-

brenda

Plasmodium vivax

-

757384

A5K8L9

UniProt

brenda

Plasmodium vivax

putative

689318

A5K8L9

UniProt

brenda

Psychromonas ingrahamii

-

737212

A1SUU0

UniProt

brenda

Psychromonas ingrahamii

gene glyA

736646, 737188

A1SUU0

UniProt

brenda

Rattus norvegicus

-

441398, 441434, 659572, 659772

-

-

brenda

Rattus norvegicus

Wistar strain

441399

-

-

brenda

Saccharolobus solfataricus

-

441422

Q9UWT5

UniProt

brenda

Saccharolobus solfataricus

-

660469

-

-

brenda

Salmonella enterica subsp. enterica serovar Typhimurium

-

441420

-

-

brenda

Salmonella enterica subsp. enterica serovar Typhimurium

gene glyA

737188

P0A2E1

UniProt

brenda

Vigna radiata

-

441434

-

-

brenda

Vigna radiata

mung bean

441408

-

-

brenda